Cancer is most accurately described as a class of diseases characterized by uncontrolled cell growth and division.There are more than a hundred defined types of cancer.

Cancer can occur in nearly every organ or tissue in the body.

Various small molecules are widely used in the research of cancer. Especially in the last decade, cancer research has evolved from a one-size-fits-all approach that emphasized cytotoxic chemotherapy to a more personalized medical strategy that focuses on the discovery and development of targeted drugs.

These drugs are designed, on a molecular level, to exploit particular genetic dependencies, addictions, and vulnerabilities of cancer cells.

Much current cancer research is concentrated in the areas of programmed cell death, tumor invasion and angiogenesis, tumor immunology, oncogenic signaling, gene expression and copy number, epigenetic regulation, toxicity and chemoresistance, metabolic stress and damage to DNA. Fermentek offers more than 30 unique biochemicals currently being used in cancer research.

Antimycin A (complex)

Antimycin A (complex)
Molecular Formula
C28H40N2O9 (for Antimycin A1)
M.W.
548.62
CAS number
1397-94-0
MSDS
Source
Streptomyces sp.
Fermentek product Code
ANT-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% (a mixture of subunits) ; refer to CoA for more data
Melting point
135°C-144°C
Solubility test
Clear colorless solution at 50mg/ml of Ethanol (slight heating)
Names and identifiers

Synonyms:

  • Antimycin  A
  • Antimycins A
  • Antipiricullin
  • Fintrol
  • Virosin

Chemical names:

IUPAC:  3-[(3-Formamido-2-hydroxybenzoyl)amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl 3-methylbutanoate

RTECS#  CD0350000

EU number
634-284-8
Description

Antimycin A is a complex of related macrocyclic lactones, predominantly A1 to A4, isolated from several species of Streptomyces, first reported in the early 1950s for potent antifungal activity. There are over 20 known analogues in the antimycin A class, mostly involving variation of the fatty acid ester chain length or adjacent alkyl starting unit. Antimycin A binds to cytochrome C reductase at the Qi site, inhibiting the oxidation of ubiquinol to ubiquinone. Antimycin A is widely used as a bioprobe of respiration and other applications with over 5,000 literature citations.

Some of data brought in this page, such as Molecular Weight, relates to Antimycin A1

 

 

InChl Key
UIFFUZWRFRDZJC-RBVQMQRASA-N
Canonical SMILES
CCCCCCC1C(C(OC(=O)C(C(OC1=O)C)NC(=O)C2=C(C(=CC=C2)NC=O)O)C)OC(=O)CC(C)C
Isomeric SMILES
CCCCCCC1[C@H]([C@@H](OC(=O)[C@H]([C@H](OC1=O)C)NC(=O)C2=C(C(=CC=C2)NC=O)O)C)OC(=O)CC(C)C
Solubility ( literature )

(lit) Antimycin A is soluble in DMSO at 2 mg/mL and in 95% ethanol at 50 mg/mL. It is also freely soluble in ether, acetone, and chloroform. It is insoluble in water.

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
CN code
Value
29419000
Title
Deleted CAS Numbers
Value
37330-19-1; 50858-98-5
Title
special link
Value
www.cdc.gov/niosh-rtecs/CD55730.html
Title
toxicity by RTECS
Value
LD50 Oral rat = 28 mg/kg; mouse oral 55 mg/kg;
Title
PG
Value
2
Title
Eco-toxicity
Value
very toxic to bone fish
Title
TSCA
Value
on extremely hazardous subst list
Fermentek Product Category
Antibiotics
Cytotoxic agents
Research field: Cancer
Apoptosis related
Anti Tumor agents
Signal to sort
A

Quote for

Price
$100.00

Ansamitocin P3

Ansamitocin P3
Molecular Formula
C32H43ClN2O9
M.W.
635.14
CAS number
66584-72-3
MSDS
Source
Actinosynnema pretoisum
Fermentek product Code
ANS-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
190°C-198°C (decomposition)
Solubility test
Clear colorless solution at 10mg/ml of Methanol
Names and identifiers

Names and synonyms

  • Maytansinol ISO-butyrate
  • Antibiotic C15003P3
  • Ansamitocin P-3
  • Ansamitocin P3

RTECS: OQ2291000

EU number
680-663-6
Chemical name
Maytansinol isobutyrate
Description

Fungal metabolite with antimitotic, antineoplastic activity. Ansamitocin P3 binds to tubulin and inhibits vinblastine-induced spiral formation

InChl Key
OPQNCARIZFLNLF-JBHFWYGFSA-N
Canonical SMILES
CC1C2CC(C(C=CC=C(CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)CC(C4(C1O4)C)OC(=O)C(C)C)C)C)OC)(NC(=O)O2)O
Isomeric SMILES
C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C/C=C(/CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@@H]([C@]4([C@H]1O4)C)OC(=O)C(C)C)C)\C)OC)(NC(=O)O2)O
Storage, handling
Deep frozen (-15 oC to - 20 oC)
Disclaimer
Refer to MSDS for further safety and handling instructions.
Ingredient type
Fermentek product
Available since
Title
validated OQ2291000 RTECS
Value
yes. Maytansinol isobutyrate
Title
transport hazards
Value
NDG
Title
identity validation
Value
NMR on the lot 002 OK
Fermentek Product Category
Antibiotics
Cytotoxic agents
Research field: Cancer
Angiogenesis related
Microtubuli assembly inhibitors
Cancer Related Compounds
Anti Tumor agents
Research field: Signal Transduction
Signal to sort
A

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Price
$1.00

Withaferin A

Withaferin A
Molecular Formula
C28H38O6
M.W.
470.60
CAS number
5119-48-2
Source
Withania somnifera (a plant)
Fermentek product Code
WIT-001
Appearance
White to off-white or slightly yellow crystalline solid.
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
225°C-235°C
Solubility test
Clear colorless solution at 20 mg/ml DMSO;
Clear colorless solution at 10 mg/ml Methanol
Names and identifiers

Synonyms

  • Withaferin E
  • 5,6-epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dienoic acid delta-lactone

RTECS: KE7288500

 

EU number
Not available (as at June 2019)
Chemical name
Withaferin A
Description

Withaferin A is a cell-permeable steroidal lactone from a medicinal plant Withania somnifera, a plant known in traditional Indian medicine.

InChl Key
DBRXOUCRJQVYJQ-CKNDUULBSA-N
Canonical SMILES
CC1=C(C(=O)OC(C1)C(C)C2CCC3C2(CCC4C3CC5C6(C4(C(=O)C=CC6O)C)O5)C)CO
Isomeric SMILES
CC1=C(C(=O)O[C@H](C1)[C@@H](C)[C@H]2CC[C@@H]3[C@@]2(CC[C@H]4[C@H]3C[C@@H]5[C@]6([C@@]4(C(=O)C=C[C@@H]6O)C)O5)C)CO
Solubility ( literature )

Methanol, Ethanol, DMSO

Compound Classification
  • Ergosterol analog
  • inhibitor of angiogenesis
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Applications

Withaferin A has shown significant anticancer activity in animal studies. Withaferin A is an angiogenesis inhibitor . Withaferin A has immunomodulating properties. Withaferin A has radiosensitizing effect on cancer cells. Withaferin A has been reported to induce neuronal regeneration.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Plant-derived
Research field: Cancer
Angiogenesis related
Apoptosis related
Protein kinase related
Signal to sort
W

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Price
$1.00

Actinomycin D

Actinomycin D
Molecular Formula
C62H86N12O16
M.W.
1 255.42
CAS number
50-76-0
MSDS
Source
Streptomyces parvulus
Fermentek product Code
ACT-001
Brand/grade
For research
Appearance
Red Shiny to Orange-Red Crystals
Purity by HPLC
≥ 95% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
238°C-255°C
Solubility test
Clear orange solution at 50mg/ml DMSO;
Clear orange solution at 10mg/ml Methanol
Names and identifiers

 

Synonyms:

  • Actinomycin IV 
  • Actinomycin C1
  • Dactinomycin
  • Cosmegen
  • Oncostatin K

Chemical names:

IUPAC: 2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide

RTECS#: AU1575000

EU number
200-063-6
Description

Actinomycin D is an antibiotic, a member of Actinomycins group, derived from Streptomyces parvullus. Actinomycin D binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines.

InChl Key
RJURFGZVJUQBHK-IIXSONLDSA-N
Canonical SMILES
CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C
Isomeric SMILES
C[C@@H]1[C@@H](C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N(CC(=O)N([C@H](C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)N[C@H]6[C@H](OC(=O)[C@@H](N(C(=O)CN(C(=O)[C@@H]7CCCN7C(=O)[C@H](NC6=O)C(C)C)C)C)C(C)C)C)N)C
Solubility ( literature )

Actinomycin D is soluble in Dichloromethane or Methanol.

Compound Classification

Oligopeptide antibiotic;

RNA polymerase inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Very photo-sensitive.
Expiration time
2Y
Applications

Inhibitor of DNA-primed RNA polymerase and DNA polymerase. An apoptosis inducer. Antineoplastic drug.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Shipped in amber-glass vials
Title
Depreciated CAS Numbers
Value
1402-51-3; 1402-58-0; 1421227-25-9;
Title
Transport information
Value
PG II
Title
sig
Value
114666
Title
TSE
Value
F
Title
CN code
Value
29419000
Fermentek Product Category
Antibiotics
Cytotoxic agents
Research field: Cancer
Signal to sort
A

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Price
$1.00
Actinomycin_D
Actinomycin_D

Nigericin (free)

Nigericin (free)
Molecular Formula
C40H68O11
M.W.
724.96
CAS number
28380-24-7
Source
Streptomyces hygroscopicus
Fermentek product Code
NIG-002
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
180-190°C
Solubility test
Clear colorless solution at 10mg/ml of
Dichloromethane
or Methanol
or Ethyl acetate
or Water
Names and identifiers

Synonyms: 

Polyetherin A; Azalomycin M; Helexin C ; Antibiotic K178;  Antibiotic X-464

Chemical names:

IUPAC:

(2R)-2-[(2R,3S,6R)-6-[[(2S,4R,5R,6R,7R,9R)-2-[(2R,5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyloxan-2-yl]propanoic acid  

RTECS# QT6825000

EU number
686-881-8
Chemical name
Polyetherin A; Azalomycin M; Helexin C ; Antibiotic K178; Antibiotic X-464
Description

Nigericin is a polyether antibiotic which affects ion transport and ATPase activity in mitochondria.

Nigericin is produced by Streptomyces hygroscopicus. Nigericin, an ionophore and antibiotic, is supplied as a free acid. It is also available as a Na salt.sodium salt.

Nigericin is one of the compounds successfully tested as a feed additive, displaying a significant effect on milk production in cattle. In vitro, nigericin has broad biological activity against Gram positive bacteria, fungi, tumor cell lines and some viruses, including HIV.

InChl Key
DANUORFCFTYTSZ-SJSJOXFOSA-N
Isomeric SMILES
C[C@H]1CC[C@@H](O[C@H]1[C@@H](C)C(=O)O)C[C@@H]2C[C@H]([C@H]([C@@]3(O2)[C@@H](C[C@@](O3)(C)[C@H]4CC[C@@](O4)(C)[C@H]5[C@H](C[C@@H](O5)[C@@H]6[C@H](C[C@H]([C@@](O6)(CO)O)C)C)C)C)C)OC
Solubility ( literature )

DMSO, Ethanol, petrol ether. Not soluble in water

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Applications

Disrupts the membrane potential and stimulates ATPase activity in mitochondria.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Fermentek Product Category
Antibiotics
Research field: Cancer
Ionophores

Quote for

Price
$1.00
Nigericin (free)
Nigericin (free)

Prodigiosin hydrochloride

Prodigiosin hydrochloride
Molecular Formula
C20H25N3O·HCl
M.W.
359.89
CAS number
56144-17-3
MSDS
Source
Serratia marcescens
Fermentek product Code
PRD-001
Brand/grade
For research
Appearance
Dark Red powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear red solution at 10mg/ml of Methanol, Clear red solution at 10mg/ml of DMSO
Names and identifiers

Synonyms:

Disambiguation:    Do not confuse with Prodigiozan, another antibiotic from the same source.

Chemical names:   2,​2'-​Bi-​1H-​pyrrole, 4-​methoxy-​5-​[(5-​methyl-​4-​pentyl-​2H-​pyrrol-​2-​ylidene)​methyl]​-​, hydrochloride (1:1)

IUPAC:                    (2Z)-3-methoxy-2-[(5-methyl-4-pentyl-1H-pyrrol-2-yl)methylidene]-5-(1H-pyrrol-2-yl)pyrrole;hydrochloride

RTECS                     DW2977000   refers to prodigiosin free base 

EU number
Not listed
Chemical name
4-Methoxy-5-[(E)-(5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl]-1H,1'H-2,2'-bipyrrole
Merck index
14: 7767
Description

Prodigiosin is a antibiotic from Serratia marcescens and some other bacterial species. It displays a wide range of biological activities, making it a promissing candidate drug. Among these are antimalarial, antifungal, anti-cancer, immunosuppressant, and antibiotic properties.

InChl Key
UQRGJSTXVCWXNU-JHMJKTBASA-N
Canonical SMILES
CCCCCC1=C(NC(=C1)C=C2C(=CC(=N2)C3=CC=CN3)OC)C.Cl
Isomeric SMILES
CCCCCC1=C(NC(=C1)/C=C/2\C(=CC(=N2)C3=CC=CN3)OC)C.Cl
Solubility ( literature )

(Data from literature including scientific publications and books, patents and other vendors)

Prodigiosin is soluble in acetonitrile, ethanol, methanol, chloroform, and DMSO. It is insoluble in water.

Compound Classification

UNSPSC

  • 51000000  Drugs and Pharmaceutical Products
  • 51200000  Immunomodulating drugs
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Other vendors may recommend higher temperatures for storage.
Applications

For research only!

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped in amber-glass vials
Transport safety: Not Dangerous Goods; Not Regulated
Transport safety: not regulated.
Available since
Title
depreciated CAS
Value
30814-03-0; 47371-61-9;
Title
Transport
Value
NDG
Fermentek Product Category
Antibiotics
Research field: Cancer
Angiogenesis related
Apoptosis related
Anti Mitotic
Anti Fungal
Anti Protozoal
Anti Parasitic
Anti Bacterial
Anti Tumor agents
Immunosupressors
Signal to sort
P

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Price
$1.00

Aloe-emodin

Aloe-emodin
Molecular Formula
C15H10O5
M.W.
270.24
CAS number
481-72-1
MSDS
Source
Aloe Vera (extracted from plant)
Fermentek product Code
ALO-001
Brand/grade
For research
Appearance
Brownish-orange powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
218°C-225°C
Solubility test
Clear orange solution at 50 mg/ml of DMSO
Names and identifiers

Synonyms:

* Aloe-emodin
* 9,10-Anthracenedione, 1,8-dihydroxy-3-(hydroxymethyl)-
* 1,8-Dihydroxy-3-(hydroxymethyl)-9,10-anthracenedione
* 1,8-Dihydroxy-3-hydroxymethylanthraquinone
* 3-Hydroxymethylchrysazin
* Rhabarberone

 

RTECS : CB6712200

 

EU number
207-571-7
Description

Aloe-emodin is a hydroxyanthraquinone found naturally in Aloe vera and in other aloe plants. It exhibits antibacterial, antiviral, anti-inflammatory and hepatoprotective effects. recently it gains interest as a candidate anti-cancer agent.

InChl Key
YDQWDHRMZQUTBA-UHFFFAOYSA-N
Canonical SMILES
C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)CO
Compound Classification

 An anthraquinone compound from Aloe Vera and other plants.

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Applications

Aloe-emodin is a drug candidate for cancer therapy.

  • It induces apoptosis in human oral squamous cell carcinoma SCC15 cells ;
  • It exerts potent anticancer effects in MIAPaCa-2 and PANC-1 human pancreatic adenocarcinoma cell lines through activation of both apoptotic and autophagic pathways, sub-G1 cell cycle arrest and disruption of mitochondrial membrane potential
  • It induced DNA damage and inhibited DNA repair gene expression in SCC-4 human tongue cancer cells.
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Transport safety: Not Dangerous Goods; Not Regulated
Available since
Title
from RTECS
Value
Mutagen in bacteria and mammalian cell cultures
Fermentek Product Category
Plant-derived
Cytotoxic agents
Enzyme-inhibitors
Research field: Cancer
Angiogenesis related
Apoptosis related
Protein kinase related
Cancer Related Compounds
Anti Tumor agents
Research area: Multi-drug resistance
Research Area: Stem Cells
Signal to sort
A

Quote for

Price
$10,000.00

Shikonin

Shikonin
Molecular Formula
C16H16O5
M.W.
288.30
CAS number
517-89-5
MSDS
Source
Alkanna sp.
Fermentek product Code
SHA-001
Brand/grade
For research
Appearance
Bordeaux brown powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear red solution at 1mg/ml of Methanol;
Clear dark red solution at 10mg/ml of DMSO
Names and identifiers

Synonyms:

  • Shikonin
  • Isoarnebin 4
  • Tokyo Violet
  • Shikonin S
  • 5,8-Dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-1,4-naphthoquinone
  • HSDB 8100

Chemical names:  Shikonin

IUPAC:  5,8-dihydroxy-2-[(1R)-1-hydroxy-4-methylpent-3-enyl]naphthalene-1,4-dione

RTECS#:   QL8000200

 
EU number
610-730-7
Description

A naphthoquinone extracted from  Lithospermum erythrorhizon.

InChl Key
NEZONWMXZKDMKF-SNVBAGLBSA-N
Canonical SMILES
CC(=CCC(C1=CC(=O)C2=C(C=CC(=C2C1=O)O)O)O)C
Isomeric SMILES
CC(=CC[C@H](C1=CC(=O)C2=C(C=CC(=C2C1=O)O)O)O)C
Compound Classification
UNSPSC 41116011  

E - Medical, Laboratory & Test Equipment & Supplies & Pharmaceuticals

  • 41000000 - Laboratory and Measuring and Observing and Testing Equipment
  • 41110000 - Measuring and observing and testing instruments
  • 41116000 - Clinical and diagnostic analyzer reagents analyzer reagents
  • 41116011 - Microbiology analyzer reagents
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Shipped in PP / PE bottle.
Available since
Title
toxicity by RTECS
Value
LD50 oral mouse >1 gm/kg
Title
Deleted CAS Registry Numbers
Value
874325-10-7; 876010-87-6
Fermentek Product Category
Plant-derived
Pyruvate kinase inhibitor
pyruvate kinase M2 specific inhibitor
Research field: Cancer
Angiogenesis related
Apoptosis related
Anti Mitotic
Anti Bacterial
Anti Tumor agents
Research field: Inflamation
Signal to sort
S

Quote for

Price
$411.00

17-DMAG-hydrochloride

17-DMAG-hydrochloride
Molecular Formula
C32H48N4O8.HCl
M.W.
653.20
CAS number
467214-21-7
MSDS
Source
Semisynthetic Derivate of Geldanamycin
Fermentek product Code
17D-002
Brand/grade
For research
Appearance
Purple powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
215°C-230°C
Solubility test
Clear purple solution at 1mg / ml H2O
Names and identifiers

Synonyms:

  • 17-DMAG HCl
  • Alvespimycin HCl
  • 17-Dimethylaminoethylamino-17-demethoxygeldanamycin Hydrochloride

IUPAC Name:

[(4E,6E,9S,10E,12S,13R,16R)-19-[2-(dimethylamino)ethylamino]-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate;hydrochloride

RTECS: LX8922000

 

Chemical name
17-dimethylaminoethylamino-17-demethoxy-geldanamycin Hydrochloride
Description

17-DMAG, also known as Alvespimycin, is a semisynthetic derivate of Geldanamycin, of less hepatotoxicity, improved water solubility.

17-DMAG is an ansamycin antibiotic which binds to Hsp90 (Heat Shock Protein 90) and alters it function.

InChl Key
DFSYBWLNYPEFJK-LYGDSXLOSA-N
Canonical SMILES
CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)C)OC)OC(=O)N)C)C)O)OC.Cl
Isomeric SMILES
C[C@H]1CC([C@@H]([C@H](/C=C(/[C@@H](C(/C=C/C=C(/C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)\C)OC)OC(=O)N)\C)C)O)OC.Cl
Solubility ( literature )

DMSO, Methanol, Ethanol

Compound Classification
  • Benzoquinone ansamycin class antibiotic
  • Geldanamycin derivate
  • HSP90 inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Applications

HSP-90 inhibitor; potential anti-cancer drug

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Shipped at ambient temperature
Shipped in PP / PE bottle.
Available since
Title
Harmonized Tariff Code
Value
294190
Title
Transport safety information
Value
Not hazardous for transport
Title
Target
Value
HGF​/SF-​mediated Met tyrosine kinase
Title
Target
Value
ATP-​binding site of amino-​terminal domain region of HSP 90
Title
CN code
Value
29419000
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Research field: Cancer
HSP90 inhibitors
Anti Tumor agents
Research Area: Stem Cells
Signal to sort
D

Quote for

Price
$10,000.00
17-DMAG_hydrochloride
17-DMAG_hydrochloride

Triptolide

Triptolide
Molecular Formula
C20H24O6
M.W.
360.40
CAS number
38748-32-2
Source
Tripterygium wilfordii
Fermentek product Code
TRP-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
223°C-230°C
Solubility test
Clear colorless solution at 10mg/ml of Acetonitrile
Names and identifiers

Synonyms:

  • NSC 163062
  • PG490

Chemical names:
Trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one, 3b,4,4a,6,6a,7a,7b,8b,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)-, (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-

IUPAC: 
(1S,2S,4S,5S,7R,8R,9S,11S,13S)-8-hydroxy-1-methyl-7-(propan-2-yl)-3,6,10,16-tetraoxaheptacyclo[11.7.0.0^{2,4}.0^{2,9}.0^{5,7}.0^{9,11}.0^{14,18}]icos-14(18)-en-17-one

RTECS#: YK7751000

EU number
683-214-2
Chemical name
Triptolide
Description

Triptolide is a diterpenoid epoxide which is produced by Tripterygium wilfordii, a vine used in traditional Chinese medicine. Triptolide has pharmacological activities including anti-inflammatory, immune-supressing, antiproliferative anti-angiogenetic, and proapoptotic activity. It has in vitro and in vivo activities against mouse models of polycystic kidney disease and pancreatic cancer.

InChl Key
DFBIRQPKNDILPW-CIVMWXNOSA-N
Canonical SMILES
CC(C)C12C(O1)C3C4(O3)C5(CCC6=C(C5CC7C4(C2O)O7)COC6=O)C
Isomeric SMILES
CC(C)[C@@]12[C@@H](O1)[C@H]3[C@@]4(O3)[C@]5(CCC6=C([C@@H]5C[C@H]7[C@]4([C@@H]2O)O7)COC6=O)C
Solubility ( literature )

Reportedly: Insoluble in water. Insoluble in Ethanol. Soluble up to 0.2Molar ( 72 mg/ml) of DMSO

Compound Classification

Chemical classification:  Terpenoid

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Retest time
2Y
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Shipped in PP / PE bottle.
Available since
Title
Transport safety
Value
NDG
Title
solubility
Value
mrck DMSO (20 mg/ml); others: 0.2 molar in DMSO
Title
source comment
Value
From plant
Fermentek Product Category
Plant-derived
Research field: Cancer
Angiogenesis related
Apoptosis related
Cancer Related Compounds
Anti Tumor agents
Immunosupressors
Signal to sort
T

Quote for

Price
$100.00
Subscribe to Research field: Cancer