Withaferin A
Molecular Formula
C28H38O6
M.W.
470.60
CAS number
5119-48-2
Source
Withania somnifera (a plant)
Fermentek product Code
WIT-001
Appearance
White to off-white or slightly yellow crystalline solid.
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
225°C-235°C
Solubility test
Clear colorless solution at 20 mg/ml DMSO;
Clear colorless solution at 10 mg/ml Methanol
Names and identifiers

Synonyms

  • Withaferin E
  • 5,6-epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dienoic acid delta-lactone

RTECS: KE7288500

 

EU number
Not available (as at June 2019)
Chemical name
Withaferin A
Description

Withaferin A is a cell-permeable steroidal lactone from a medicinal plant Withania somnifera, a plant known in traditional Indian medicine.

InChl Key
DBRXOUCRJQVYJQ-CKNDUULBSA-N
Canonical SMILES
CC1=C(C(=O)OC(C1)C(C)C2CCC3C2(CCC4C3CC5C6(C4(C(=O)C=CC6O)C)O5)C)CO
Isomeric SMILES
CC1=C(C(=O)O[C@H](C1)[C@@H](C)[C@H]2CC[C@@H]3[C@@]2(CC[C@H]4[C@H]3C[C@@H]5[C@]6([C@@]4(C(=O)C=C[C@@H]6O)C)O5)C)CO
Solubility ( literature )

Methanol, Ethanol, DMSO

Compound Classification
  • Ergosterol analog
  • inhibitor of angiogenesis
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Applications

Withaferin A has shown significant anticancer activity in animal studies. Withaferin A is an angiogenesis inhibitor . Withaferin A has immunomodulating properties. Withaferin A has radiosensitizing effect on cancer cells. Withaferin A has been reported to induce neuronal regeneration.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Signal to sort
W