Aloe-emodin
Molecular Formula
C15H10O5
M.W.
270.24
CAS number
481-72-1
MSDS
Details
Source
Aloe Vera (extracted from plant)
Fermentek product Code
ALO-001
Brand/grade
For research
Specifications
Appearance
Brownish-orange powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
218°C-225°C
Solubility test
Clear orange solution at 50 mg/ml of DMSO
Chemical identification
Names and identifiers
Synonyms:
* Aloe-emodin
* 9,10-Anthracenedione, 1,8-dihydroxy-3-(hydroxymethyl)-
* 1,8-Dihydroxy-3-(hydroxymethyl)-9,10-anthracenedione
* 1,8-Dihydroxy-3-hydroxymethylanthraquinone
* 3-Hydroxymethylchrysazin
* Rhabarberone
RTECS : CB6712200
EU number
207-571-7
Description
Aloe-emodin is a hydroxyanthraquinone found naturally in Aloe vera and in other aloe plants. It exhibits antibacterial, antiviral, anti-inflammatory and hepatoprotective effects. recently it gains interest as a candidate anti-cancer agent.
InChl Key
YDQWDHRMZQUTBA-UHFFFAOYSA-N
Canonical SMILES
C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)CO
Further Information
Compound Classification
An anthraquinone compound from Aloe Vera and other plants.
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Applications
Aloe-emodin is a drug candidate for cancer therapy.
- It induces apoptosis in human oral squamous cell carcinoma SCC15 cells ;
- It exerts potent anticancer effects in MIAPaCa-2 and PANC-1 human pancreatic adenocarcinoma cell lines through activation of both apoptotic and autophagic pathways, sub-G1 cell cycle arrest and disruption of mitochondrial membrane potential
- It induced DNA damage and inhibited DNA repair gene expression in SCC-4 human tongue cancer cells.
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Composition
Ingredient type
Fermentek product
Supply related information
Transport safety: Not Dangerous Goods; Not Regulated
Special Info
Available since
Other Fields
Title
from RTECS
Value
Mutagen in bacteria and mammalian cell cultures
Fermentek Product Category
Signal to sort
A
