* 9,10-Anthracenedione, 1,8-dihydroxy-3-(hydroxymethyl)-
RTECS : CB6712200
Aloe-emodin is a hydroxyanthraquinone found naturally in Aloe vera and in other aloe plants. It exhibits antibacterial, antiviral, anti-inflammatory and hepatoprotective effects. recently it gains interest as a candidate anti-cancer agent.
An anthraquinone compound from Aloe Vera and other plants.
Aloe-emodin is a drug candidate for cancer therapy.
- It induces apoptosis in human oral squamous cell carcinoma SCC15 cells ;
- It exerts potent anticancer effects in MIAPaCa-2 and PANC-1 human pancreatic adenocarcinoma cell lines through activation of both apoptotic and autophagic pathways, sub-G1 cell cycle arrest and disruption of mitochondrial membrane potential
- It induced DNA damage and inhibited DNA repair gene expression in SCC-4 human tongue cancer cells.