Antimycin A (complex)

Antimycin A (complex)
Molecular Formula
C28H40N2O9 (for Antimycin A1)
M.W.
548.62
CAS number
1397-94-0
MSDS
Source
Streptomyces sp.
Fermentek product Code
ANT-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% (a mixture of subunits) ; refer to CoA for more data
Melting point
135°C-144°C
Solubility test
Clear colorless solution at 50mg/ml of Ethanol (slight heating)
Names and identifiers

Synonyms:

  • Antimycin  A
  • Antimycins A
  • Antipiricullin
  • Fintrol
  • Virosin

Chemical names:

IUPAC:  3-[(3-Formamido-2-hydroxybenzoyl)amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl 3-methylbutanoate

RTECS#  CD0350000

EU number
634-284-8
Description

Antimycin A is a complex of related macrocyclic lactones, predominantly A1 to A4, isolated from several species of Streptomyces, first reported in the early 1950s for potent antifungal activity. There are over 20 known analogues in the antimycin A class, mostly involving variation of the fatty acid ester chain length or adjacent alkyl starting unit. Antimycin A binds to cytochrome C reductase at the Qi site, inhibiting the oxidation of ubiquinol to ubiquinone. Antimycin A is widely used as a bioprobe of respiration and other applications with over 5,000 literature citations.

Some of data brought in this page, such as Molecular Weight, relates to Antimycin A1

 

 

InChl Key
UIFFUZWRFRDZJC-RBVQMQRASA-N
Canonical SMILES
CCCCCCC1C(C(OC(=O)C(C(OC1=O)C)NC(=O)C2=C(C(=CC=C2)NC=O)O)C)OC(=O)CC(C)C
Isomeric SMILES
CCCCCCC1[C@H]([C@@H](OC(=O)[C@H]([C@H](OC1=O)C)NC(=O)C2=C(C(=CC=C2)NC=O)O)C)OC(=O)CC(C)C
Solubility ( literature )

(lit) Antimycin A is soluble in DMSO at 2 mg/mL and in 95% ethanol at 50 mg/mL. It is also freely soluble in ether, acetone, and chloroform. It is insoluble in water.

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
CN code
Value
29419000
Title
Deleted CAS Numbers
Value
37330-19-1; 50858-98-5
Title
special link
Value
www.cdc.gov/niosh-rtecs/CD55730.html
Title
toxicity by RTECS
Value
LD50 Oral rat = 28 mg/kg; mouse oral 55 mg/kg;
Title
PG
Value
2
Title
Eco-toxicity
Value
very toxic to bone fish
Title
TSCA
Value
on extremely hazardous subst list
Signal to sort
A

Ansamitocin P3

Ansamitocin P3
Molecular Formula
C32H43ClN2O9
M.W.
635.14
CAS number
66584-72-3
MSDS
Source
Actinosynnema pretoisum
Fermentek product Code
ANS-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
190°C-198°C (decomposition)
Solubility test
Clear colorless solution at 10mg/ml of Methanol
Names and identifiers

Names and synonyms

  • Maytansinol ISO-butyrate
  • Antibiotic C15003P3
  • Ansamitocin P-3
  • Ansamitocin P3

RTECSOQ2291000

EU number
680-663-6
Chemical name
Maytansinol isobutyrate
Description

Fungal metabolite with antimitotic, antineoplastic activity. Ansamitocin P3 binds to tubulin and inhibits vinblastine-induced spiral formation

InChl Key
OPQNCARIZFLNLF-JBHFWYGFSA-N
Canonical SMILES
CC1C2CC(C(C=CC=C(CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)CC(C4(C1O4)C)OC(=O)C(C)C)C)C)OC)(NC(=O)O2)O
Isomeric SMILES
C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C/C=C(/CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@@H]([C@]4([C@H]1O4)C)OC(=O)C(C)C)C)\C)OC)(NC(=O)O2)O
Storage, handling
Deep frozen (-15 oC to - 20 oC)
Disclaimer
Refer to MSDS for further safety and handling instructions.
Ingredient type
Fermentek product
Available since
Title
validated OQ2291000 RTECS
Value
yes. Maytansinol isobutyrate
Title
transport hazards
Value
NDG
Title
identity validation
Value
NMR on the lot 002 OK
Signal to sort
A

Thapsigargicin

Thapsigargicin
Molecular Formula
C32H46O12
M.W.
622.70
CAS number
67526-94-7
MSDS
Source
Thapsia garganica
Fermentek product Code
THC-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml Acetonitrile
Names and identifiers

Synonyms:
Hexanoic acid, (3S,​3aR,​4S,​6S,​6aR,​7S,​8S,​9bS)​-​6-​(acetyloxy)​-​2,​3,​3a,​4,​5,​6,​6a,​7,​8,​9b-​decahydro-​3,​3a-​dihydroxy-​3,​6,​9-​trimethyl-​8-​[[(2Z)​-​2-​methyl-​1-​oxo-​2-​buten-​1-​yl]​oxy]​-​2-​oxo-​4-​(1-​oxobutoxy)​azuleno[4,​5-​b]​furan-​7-​yl ester

Chemical names:

IUPAC:    (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-Acetoxy-4-(butyryloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-{[(2Z)-2-methyl-2-butenoyl]oxy}-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-7-yl hexanoate

RTECS#    Not available

 

EU number
636-165-6
Description

Hexaoxygenated tetra-acylated sesquiterpene lactone tetraester isolated from roots of Thapsia garganica; it induces mast cell degranulation and histamine release; it is an analog of thapsigargin.

InChl Key
LXWLOFYIORKNSA-FFOGNQQCSA-N
Canonical SMILES
CCCCCC(=O)OC1C2C(=C(C1OC(=O)C(=CC)C)C)C3C(C(CC2(C)OC(=O)C)OC(=O)CCC)(C(C(=O)O3)(C)O)O
Isomeric SMILES
CCCCCC(=O)O[C@H]1[C@H]2C(=C([C@@H]1OC(=O)/C(=C\C)/C)C)[C@H]3[C@]([C@H](C[C@]2(C)OC(=O)C)OC(=O)CCC)([C@](C(=O)O3)(C)O)O
Compound Classification

Chemical classification: Sesquiterpene
Hexaoxygenated tetraacylated sesquiterpene lactone tetraester .

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Transport safety: Not Dangerous Goods; Not Regulated
Available since

Prodigiosin hydrochloride

Prodigiosin hydrochloride
Molecular Formula
C20H25N3O·HCl
M.W.
359.89
CAS number
56144-17-3
MSDS
Source
Serratia marcescens
Fermentek product Code
PRD-001
Brand/grade
For research
Appearance
Dark Red powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear red solution at 10mg/ml of Methanol, Clear red solution at 10mg/ml of DMSO
Names and identifiers

Synonyms:

Disambiguation:    Do not confuse with Prodigiozan, another antibiotic from the same source.

Chemical names:   2,​2'-​Bi-​1H-​pyrrole, 4-​methoxy-​5-​[(5-​methyl-​4-​pentyl-​2H-​pyrrol-​2-​ylidene)​methyl]​-​, hydrochloride (1:1)

IUPAC:                    (2Z)-3-methoxy-2-[(5-methyl-4-pentyl-1H-pyrrol-2-yl)methylidene]-5-(1H-pyrrol-2-yl)pyrrole;hydrochloride

RTECS                     DW2977000   refers to prodigiosin free base 

EU number
Not listed
Chemical name
4-Methoxy-5-[(E)-(5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl]-1H,1'H-2,2'-bipyrrole
Merck index
14: 7767
Description

Prodigiosin is a antibiotic from Serratia marcescens and some other bacterial species. It displays a wide range of biological activities, making it a promissing candidate drug. Among these are antimalarial, antifungal, anti-cancer, immunosuppressant, and antibiotic properties.

InChl Key
UQRGJSTXVCWXNU-JHMJKTBASA-N
Canonical SMILES
CCCCCC1=C(NC(=C1)C=C2C(=CC(=N2)C3=CC=CN3)OC)C.Cl
Isomeric SMILES
CCCCCC1=C(NC(=C1)/C=C/2\C(=CC(=N2)C3=CC=CN3)OC)C.Cl
Solubility ( literature )

(Data from literature including scientific publications and books, patents and other vendors)

Prodigiosin is soluble in acetonitrile, ethanol, methanol, chloroform, and DMSO. It is insoluble in water.

Compound Classification

UNSPSC

  • 51000000  Drugs and Pharmaceutical Products
  • 51200000  Immunomodulating drugs
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Other vendors may recommend higher temperatures for storage.
Applications

For research only!

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped in amber-glass vials
Transport safety: Not Dangerous Goods; Not Regulated
Transport safety: not regulated.
Available since

Aloe-emodin

Aloe-emodin
Molecular Formula
C15H10O5
M.W.
270.24
CAS number
481-72-1
MSDS
Source
Aloe Vera (extracted from plant)
Fermentek product Code
ALO-001
Brand/grade
For research
Appearance
Brownish-orange powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
218°C-225°C
Solubility test
Clear orange solution at 50 mg/ml of DMSO
Names and identifiers

Synonyms:

* Aloe-emodin
* 9,10-Anthracenedione, 1,8-dihydroxy-3-(hydroxymethyl)-
* 1,8-Dihydroxy-3-(hydroxymethyl)-9,10-anthracenedione
* 1,8-Dihydroxy-3-hydroxymethylanthraquinone
* 3-Hydroxymethylchrysazin
* Rhabarberone

 

RTECS : CB6712200

 

EU number
207-571-7
Description

Aloe-emodin is a hydroxyanthraquinone found naturally in Aloe vera and in other aloe plants. It exhibits antibacterial, antiviral, anti-inflammatory and hepatoprotective effects. recently it gains interest as a candidate anti-cancer agent.

InChl Key
YDQWDHRMZQUTBA-UHFFFAOYSA-N
Canonical SMILES
C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)CO
Compound Classification

 An anthraquinone compound from Aloe Vera and other plants.

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Applications

Aloe-emodin is a drug candidate for cancer therapy.

  • It induces apoptosis in human oral squamous cell carcinoma SCC15 cells ;
  • It exerts potent anticancer effects in MIAPaCa-2 and PANC-1 human pancreatic adenocarcinoma cell lines through activation of both apoptotic and autophagic pathways, sub-G1 cell cycle arrest and disruption of mitochondrial membrane potential
  • It induced DNA damage and inhibited DNA repair gene expression in SCC-4 human tongue cancer cells.
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Transport safety: Not Dangerous Goods; Not Regulated
Available since

Bongkrekic acid (as solution)

Bongkrekic acid (as solution)
Molecular Formula
C28H38O7
M.W.
486.60
CAS number
11076-19-0
MSDS
Source
Pseudomonas gladioli
Fermentek product Code
BON-001
Brand/grade
For research
Appearance
Clear colorless solution
Purity by HPLC
≥95% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Names and identifiers

Synonyms:

  • Bongkrekic Acid
  • Flavotoxin A

Chemical names:

IUPAC:

  • (6R,17S)-20-(carboxymethyl)-6-methoxy-2,5,17-trimethyldocosa-2,4,8,10,14,18,20-heptaenedioic acid

RTECS    

EU number
Not assigned
Chemical name
Bongkrekic acid
Description

Supplied as 1mg/ml solution dissolved in 0.01M Tris buffer pH 7.5. 

InChl Key
SHCXABJSXUACKU-WUTQZGRKSA-N
Canonical SMILES
CC(CC=CCCC=CC=CCC(C(=CC=C(C)C(=O)O)C)OC)C=CC(=CC(=O)O)CC(=O)O
Isomeric SMILES
CC(C/C=C/CC/C=C/C=C\CC(/C(=C\C=C(/C)\C(=O)O)/C)OC)/C=C/C(=C\C(=O)O)/CC(=O)O
Solubility ( literature )
  • Solubility in Water: ~ 1 mg/ml
  • Solubility Notes: ~100 mg/ml in DMSO
Compound Classification
  • Chemical classification:
  • Polyunsaturated tricarboxylic acid

Bioactivity:

  • Glutathione transferase inhibitor
  • ATP/ADP translocase inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Applications

 Bongcrekic acid is an inhibitor of adenine nucleotide translocator, which inhibits apoptosis, and is thus an important tool for the mechanistic investigation of apoptosis.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Ingredient amount
1 mg/ml in 0.01M Tris buffer pH 7.5
Shipped at ambient temperature
Shipped in PP / PE bottle.
Available since
Title
CAS ambiguity
Value
# 60132-21-0 belongs to Isobongkrekic acid . http://www.molbase.com/en/cas-60132-21-0.html
Title
oral LD50
Value
oral LD50 of the purified Flavotoxin A in mice 3.16 mg/kg
Title
More identity comments; Hu WJ et al; Biomed Environ Sci 2 (1): 65-71 (1989)
Value
Therefore, Flavotoxin A and bongkrekic acid are the same organic chemical compound; the molecular formula is C28H38O7. The oral LD50 of the purified Flavotoxin A in mice was 3.16 mg/kg (1.53-6.15 mg/kg).
Title
Deleted CAS Registry Numbers
Value
11002-93-0, 12715-13-8, 32839-39-7
Title
oral LD50
Value
ANOTHER SOURCE: MOUSE LDL0=6.85 mg/kg PMID:6391376
Signal to sort
B

Shikonin

Shikonin
Molecular Formula
C16H16O5
M.W.
288.30
CAS number
517-89-5
MSDS
Source
Alkanna sp.
Fermentek product Code
SHA-001
Brand/grade
For research
Appearance
Bordeaux brown powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear red solution at 1mg/ml of Methanol;
Clear dark red solution at 10mg/ml of DMSO
Names and identifiers

Synonyms:

  • Shikonin
  • Isoarnebin 4
  • Tokyo Violet
  • Shikonin S
  • 5,8-Dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-1,4-naphthoquinone
  • HSDB 8100

Chemical names:  Shikonin

IUPAC:  5,8-dihydroxy-2-[(1R)-1-hydroxy-4-methylpent-3-enyl]naphthalene-1,4-dione

RTECS#:   QL8000200

 
EU number
610-730-7
Description

A naphthoquinone extracted from  Lithospermum erythrorhizon.

InChl Key
NEZONWMXZKDMKF-SNVBAGLBSA-N
Canonical SMILES
CC(=CCC(C1=CC(=O)C2=C(C=CC(=C2C1=O)O)O)O)C
Isomeric SMILES
CC(=CC[C@H](C1=CC(=O)C2=C(C=CC(=C2C1=O)O)O)O)C
Compound Classification
UNSPSC 41116011  

E - Medical, Laboratory & Test Equipment & Supplies & Pharmaceuticals

  • 41000000 - Laboratory and Measuring and Observing and Testing Equipment
  • 41110000 - Measuring and observing and testing instruments
  • 41116000 - Clinical and diagnostic analyzer reagents analyzer reagents
  • 41116011 - Microbiology analyzer reagents
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Shipped in PP / PE bottle.
Available since
Title
toxicity by RTECS
Value
LD50 oral mouse >1 gm/kg
Title
Deleted CAS Registry Numbers
Value
874325-10-7; 876010-87-6
Signal to sort
S

Bleomycin sulfate

Bleomycin sulfate
Molecular Formula
C55H85N17O25S4
M.W.
1 512.62
CAS number
9041-93-4
MSDS
Source
Streptomyces verticillus
Fermentek product Code
BLE-001
Brand/grade
For research
Appearance
White to slight yellow powder
Purity by HPLC
≥95% (complex of A2, B2) ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
188-205°C
Solubility test
Clear colorless solution at 20mg/ml of Water,
Clear colorless solution at 20mg/ml of DMSO
Names and identifiers

Synonyms:

  • Blenoxane
  • Bleomycin B2
  • BLEOcell

Chemical names:

  • Bleomycin Sulfate (A mixture of bleomycin sulfate salts)

RTECS#     EC5991990

 
EU number
232-925-2
Description

A non-ribosomal glycopeptide antitumor antibiotic which produces single and double-strand DNA breaks in tumor cells thus  interrupting their cell cycle; has been used for the treatment of Hodgkin’s lymphoma in combination with doxorubicin, squamous cell carcinomas, testicular cancer, as well as in animal models of pulmonary fibrosis.

InChl Key
WUIABRMSWOKTOF-OCBSMOPSSA-N
Canonical SMILES
CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=O)N)O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O.OS(=O)(=O)[O-]
Isomeric SMILES
CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)O[C@H]3[C@H]([C@H]([C@@H]([C@@H](O3)CO)O)O)O[C@@H]4[C@H]([C@H]([C@@H]([C@H](O4)CO)O)OC(=O)N)O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O.OS(=O)(=O)[O-]
Solubility ( literature )

Solubility in water 10 mg/ml; other sources: H2O: 20 mg/mL

Compound Classification
  • Chemical Classification: Glycopeptide
  • Biological classification: Antibiotics, Antineoplastic

UNSPSC: 51111701

  • E - Medical, Laboratory & Test Equipment & Supplies & Pharmaceuticals
  • 51000000 - Drugs and Pharmaceutical Products
  • 51280000 - Antibacterials
  • 51283200 - Macrolides
     
  • 51110000 - Antineoplastic agents
  • 51111700 - Antineoplastic antibiotics
  • 51111701 - Bleomycin sulphate
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Other vendors may recommend higher temperatures for storage.
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Shipped in PP / PE bottle.
Available since
Title
Deleted CAS-RN
Value
134171-41-8
Title
Composition for lot BLE001:
Value
Bleomycin A2: 67.81%; Bleomycin B2: 31.62% by HPLC
Signal to sort
B

Emodin

Emodin
Molecular Formula
C15H10O5
M.W.
270.24
CAS number
518-82-1
MSDS
Fermentek product Code
EMO-001
Brand/grade
For research
Appearance
Orange Powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
255°C-265°C
Solubility test
Clear yellow to red solution at 50mg/ml of DMSO;
Clear yellow to red solution at 10mg/ml of Ethanol (may need a little warming)
Names and identifiers

Synonyms

  • Archin
  • Emodol
  • Frangula emodin
  • Frangulic acid
  • Rheum emodin

 Chemical names    Emodin

RTECS                    CB7920600

EU number
208-258-8
Chemical name
Emodin
Description

 Emodin is an anthraquinone class compound. It is sourced from a plant Rheum palmatum. It exhibits antibacterial, anti-neoplastic, anti-inflammatory and anti-angiogenesis properties. 

InChl Key
RHMXXJGYXNZAPX-UHFFFAOYSA-N
Canonical SMILES
C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)O
Solubility ( literature )

Water Solubility <0.1 g/100 mL at 19ºC ; Practically insoluble in water; soluble in alcohol, aqueous alkali hydroxide solutions (cherry red color), (src: Merck index)

Compound Classification

Emodin has been investigated for the treatment of Polycystic Kidney.

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Shipped in PP / PE bottle.
Available since
Title
phys appearance
Value
Emodin appears as orange needles or powder.
Title
CN EU 29146980
Value
Ketones and quinones; Quinones; Other; Other
Title
Usage:
Value
Only for research in the field of cancer
Title
Usage:
Value
Emodin has been investigated for the treatment of Polycystic Kidney
Signal to sort
E

17-DMAG-hydrochloride

17-DMAG-hydrochloride
Molecular Formula
C32H48N4O8.HCl
M.W.
653.20
CAS number
467214-21-7
MSDS
Source
Semisynthetic Derivate of Geldanamycin
Fermentek product Code
17D-002
Brand/grade
For research
Appearance
Purple powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
215°C-230°C
Solubility test
Clear purple solution at 1mg / ml H2O
Names and identifiers

Synonyms:

  • 17-DMAG HCl
  • Alvespimycin HCl
  • 17-Dimethylaminoethylamino-17-demethoxygeldanamycin Hydrochloride

IUPAC Name:

[(4E,6E,9S,10E,12S,13R,16R)-19-[2-(dimethylamino)ethylamino]-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate;hydrochloride

RTECS: LX8922000

 

Chemical name
17-dimethylaminoethylamino-17-demethoxy-geldanamycin Hydrochloride
Description

17-DMAG, also known as Alvespimycin, is a semisynthetic derivate of Geldanamycin, of less hepatotoxicity, improved water solubility.

17-DMAG is an ansamycin antibiotic which binds to Hsp90 (Heat Shock Protein 90) and alters it function.

InChl Key
DFSYBWLNYPEFJK-LYGDSXLOSA-N
Canonical SMILES
CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)C)OC)OC(=O)N)C)C)O)OC.Cl
Isomeric SMILES
C[C@H]1CC([C@@H]([C@H](/C=C(/[C@@H](C(/C=C/C=C(/C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)\C)OC)OC(=O)N)\C)C)O)OC.Cl
Solubility ( literature )

DMSO, Methanol, Ethanol

Compound Classification
  • Benzoquinone ansamycin class antibiotic
  • Geldanamycin derivate
  • HSP90 inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Applications

HSP-90 inhibitor; potential anti-cancer drug

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Shipped at ambient temperature
Shipped in PP / PE bottle.
Available since
Title
Harmonized Tariff Code
Value
294190
Title
Transport safety information
Value
Not hazardous for transport
Title
Target
Value
HGF​/SF-​mediated Met tyrosine kinase
Title
Target
Value
ATP-​binding site of amino-​terminal domain region of HSP 90
Title
CN code
Value
29419000
Signal to sort
D