Ansamitocin P3

Ansamitocin P3
Molecular Formula
C32H43ClN2O9
M.W.
635.14
CAS number
66584-72-3
MSDS
Source
Actinosynnema pretoisum
Fermentek product Code
ANS-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
190°C-198°C (decomposition)
Solubility test
Clear colorless solution at 10mg/ml of Methanol
Names and identifiers

Names and synonyms

  • Maytansinol ISO-butyrate
  • Antibiotic C15003P3
  • Ansamitocin P-3
  • Ansamitocin P3

RTECS: OQ2291000

EU number
680-663-6
Chemical name
Maytansinol isobutyrate
Description

Fungal metabolite with antimitotic, antineoplastic activity. Ansamitocin P3 binds to tubulin and inhibits vinblastine-induced spiral formation

InChl Key
OPQNCARIZFLNLF-JBHFWYGFSA-N
Canonical SMILES
CC1C2CC(C(C=CC=C(CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)CC(C4(C1O4)C)OC(=O)C(C)C)C)C)OC)(NC(=O)O2)O
Isomeric SMILES
C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C/C=C(/CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@@H]([C@]4([C@H]1O4)C)OC(=O)C(C)C)C)\C)OC)(NC(=O)O2)O
Storage, handling
Deep frozen (-15 oC to - 20 oC)
Retest time
3 Years
Disclaimer
Refer to MSDS for further safety and handling instructions.
Ingredient type
Fermentek product
Available since
Title
validated OQ2291000 RTECS
Value
yes. Maytansinol isobutyrate
Title
transport hazards
Value
NDG
Title
identity validation
Value
NMR on the lot 002 OK
Fermentek Product Category
Antibiotics
Cytotoxic agents
Research field: Cancer
Angiogenesis related
Microtubuli assembly inhibitors
Cancer Related Compounds
Anti Tumor agents
Research field: Signal Transduction
Signal to sort
A

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Phomopsin A

Phomopsin A
Molecular Formula
C36H45ClN6O12
M.W.
789.20
CAS number
64925-80-0
Source
Phomopsis leptostromiformis
Fermentek product Code
PHA-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml of DMSO ;
Clear colorless solution at 5 mg/ml of Methanol
Names and identifiers

IUPAC:  (2E)-2-{[(2E)-2-({[(2S)-1-{[(3R,4S,7S,10S,11S)-14-Chloro-3-ethyl-11,15-dihydroxy-7-isopropenyl-3-methyl-10-(methylamino)-6,9-dioxo-2-oxa-5,8-diazabicyclo[10.3.1]hexadeca-1(16),12,14-trien-4-yl]carbony l}-2,5-dihydro-1H-pyrrol-2-yl]carbonyl}amino)-3-methyl-2-pentenoyl]amino}-2-butenedioic acid

RTECS# SY2593000

Chemical name
Phomopsin A
Description

Cyclic hexapeptide antibiotic. Phomopsin A exhibits very strong inhibitory properties of microtubule assembly. It binds to tubulin at a site different from the colchicine binding site.

InChl Key
FAFRRYBYQKPKSY-AJSRVUJESA-N
Canonical SMILES
CCC(=C(C(=O)NC(=CC(=O)O)C(=O)O)NC(=O)C1C=CCN1C(=O)C2C(OC3=C(C(=CC(=C3)C(C(C(=O)NC(C(=O)N2)C(=C)C)NC)O)Cl)O)(C)CC)C
Isomeric SMILES
CC/C(=C(\C(=O)N/C(=C/C(=O)O)/C(=O)O)/NC(=O)[C@@H]1C=CCN1C(=O)[C@@H]2[C@@](OC3=C(C(=CC(=C3)[C@@H]([C@@H](C(=O)N[C@H](C(=O)N2)C(=C)C)NC)O)Cl)O)(C)CC)/C
Solubility ( literature )

Soluble in Ethanol, Methanol, DMSO and DMF. Sparingly siluble in water. Not stable in watery solutions. (lit).

Compound Classification

Classification by Bioactivity

  • Agent that interacts with TUBULIN to inhibit or promote polymerization of MICROTUBULES
  • A potent microtubule inhibitor

Chemical Classification

  • Hexapeptide
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Expiration time
3Y
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Title
Deleted CAS Numbers
Value
126061-16-3
Title
Transport safety
Value
NDG
Title
EC registration
Value
not EC, validated 2-Apr-19
Fermentek Product Category
Mycotoxins
Research field: Cancer
Protein kinase related
Microtubuli assembly inhibitors
Anti Mitotic
Anti Fungal
Anti Bacterial
Cyclic hexapeptide antibiotic
Research field: Immunology
Research field: Inflamation
Signal to sort
P

Quote for

Price
$1.00
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