In higher (multicellular) organisms, many processes are required for coordinating individual cells to act as parts of the whole. Among these we may count attraction of spermatozoides by ovum, environment sensing in general, cellular response to hormones and neuro transmitters, initiating and terminating cells multiplication, or imposing apoptosis on unneeded cells during ontogenesis.

Usually, Signal-Transduction would begin with binding of the singnal-molecule to a receptor on the cell-membrane, altering its configuration and thus starting a chain of reactions within the cell. These reactions may include (de)acetylations, (de)/phosphorilations on the participating molcules.

The Signal Transduction related reagents may by further classified as

  • Ca++-ATPase inhibitors, such as Artemisinin, Cyclopiazonic acid, Thapsigargin, Paxilline
  • SERCA Ca2+-ATPase stimulator/ activator, such as Ochratoxin A
  • Hedgehog signalling inhibitors: Cyclopamine

 

Ansamitocin P3

Ansamitocin P3
Molecular Formula
C32H43ClN2O9
M.W.
635.14
CAS number
66584-72-3
MSDS
Source
Actinosynnema pretoisum
Fermentek product Code
ANS-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
190°C-198°C (decomposition)
Solubility test
Clear colorless solution at 10mg/ml of Methanol
Names and identifiers

Names and synonyms

  • Maytansinol ISO-butyrate
  • Antibiotic C15003P3
  • Ansamitocin P-3
  • Ansamitocin P3

RTECS: OQ2291000

EU number
680-663-6
Chemical name
Maytansinol isobutyrate
Description

Fungal metabolite with antimitotic, antineoplastic activity. Ansamitocin P3 binds to tubulin and inhibits vinblastine-induced spiral formation

InChl Key
OPQNCARIZFLNLF-JBHFWYGFSA-N
Canonical SMILES
CC1C2CC(C(C=CC=C(CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)CC(C4(C1O4)C)OC(=O)C(C)C)C)C)OC)(NC(=O)O2)O
Isomeric SMILES
C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C/C=C(/CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@@H]([C@]4([C@H]1O4)C)OC(=O)C(C)C)C)\C)OC)(NC(=O)O2)O
Storage, handling
Deep frozen (-15 oC to - 20 oC)
Disclaimer
Refer to MSDS for further safety and handling instructions.
Ingredient type
Fermentek product
Available since
Title
validated OQ2291000 RTECS
Value
yes. Maytansinol isobutyrate
Title
transport hazards
Value
NDG
Title
identity validation
Value
NMR on the lot 002 OK
Fermentek Product Category
Antibiotics
Cytotoxic agents
Research field: Cancer
Angiogenesis related
Microtubuli assembly inhibitors
Cancer Related Compounds
Anti Tumor agents
Research field: Signal Transduction
Signal to sort
A

Quote for

Price
$1.00

Fumonisin B4

Fumonisin B4
Molecular Formula
C34H59NO13
M.W.
689.83
CAS number
136379-60-7
Source
Fusarium moniliforme
Fermentek product Code
FB4-001
Brand/grade
For research
Appearance
White to off white to brown lyophilizate
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless to yellow to brown solution at 5mg/ml Methanol or 50mg/ml DMSO
Names and identifiers

Synonyms:

Chemical names:

IUPAC:

(2R,2'R)-2,2'-{[(5R,6R,7S,9S,18S,19S)-19-Amino-18-hydroxy-5,9-dimethyl-6,7-icosanediyl]bis[oxy(2-oxo-2,1-ethanediyl)]}disuccinic acid [ACD/IUPAC Name]

RTECS# TZ8345000

EU number
Not listed as on Aug-2023
Chemical name
(2R,2'R)-2,2'-{[(5R,6R,7S,9S,18S,19S)-19-Amino-18-hydroxy-5,9-dimethyl-6,7-icosanediyl]bis[oxy(2-oxo-2,1-ethanediyl)]}disuccinic acid
Description

 Fumonisin B4 is a mycotoxin of the fumonisin family. It is produced by several Fusarium and Aspergillus species. It is less abundant in the nature than the other three "main" fumonisins.  

InChl Key
WYYKRDVIBOEORL-JLCKPESSSA-N
Canonical SMILES
CCCCC(C)C(C(CC(C)CCCCCCCCC(C(C)N)O)OC(=O)CC(CC(=O)O)C(=O)O)OC(=O)CC(CC(=O)O)C(=O)O
Isomeric SMILES
CCCC[C@@H](C)[C@H]([C@H](C[C@@H](C)CCCCCCCC[C@@H]([C@H](C)N)O)OC(=O)C[C@@H](CC(=O)O)C(=O)O)OC(=O)C[C@@H](CC(=O)O)C(=O)O
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Protect from moisture!
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Available since
Fermentek Product Category
Mycotoxins
Cancer Related Compounds
Research field: Signal Transduction

Quote for

Price
$1.00
Fumonisin B4
Fumonisin B4

Fidaxomicin

Fidaxomicin
Molecular Formula
C52H74Cl2O18
M.W.
1 058.00
CAS number
873857-62-6
MSDS
Source
Dactylosporangium aurantiacum (An Actinobecterium)
Fermentek product Code
FID-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
160°C-170°C
Solubility test
Clear colorless to faint yellow solution at 1mg/ml of DMSO;
Clear colorless to faint yellow solution at 5 mg/ml of Methanol
Names and identifiers

Synonyms:

  • Dificid,
  • Dificlir, 
  • Clostomicin B1,
  • lipiarmicin,
  • lipiarmycin,
  • lipiarmycin A3, 
  • tiacumicin B

Chemical names:

IUPAC:   [(2R,3S,4S,5S,6R)-6-[[(3E,5E,8S,9E,11S,12R,13E,15E,18S)-12-[(2R,3S,4R,5S)-3,4-dihydroxy-6,6-dimethyl-5-(2-methylpropanoyloxy)oxan-2-yl]oxy-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyl-2-oxo-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl]methoxy]-4-hydroxy-5-methoxy-2-methyloxan-3-yl] 3,5-dichloro-2-ethyl-4,6-dihydroxybenzoate

RTECS#  Not available

EU number
692-555-6
Chemical name
Fidaxomicin
Description

Fidaxomicin is a narrow spectrum macrocyclic antibiotic, sourced from actinomycete Dactylosporangium aurantiacum. Fidaxomicin is non-systemic, meaning it is minimally absorbed into the bloodstream. This anti-bacterial agent  selectively acts against pathogenic Clostridium difficile bacteria which may infect the colon, while causing minimal damage to the natural intestinal microbial flora.

InChl Key
ZVGNESXIJDCBKN-UUEYKCAUSA-N
Canonical SMILES
CCC1C=C(C(CC=CC=C(C(=O)OC(CC=C(C=C(C1OC2C(C(C(C(O2)(C)C)OC(=O)C(C)C)O)O)C)C)C(C)O)COC3C(C(C(C(O3)C)OC(=O)C4=C(C(=C(C(=C4O)Cl)O)Cl)CC)O)OC)O)C
Isomeric SMILES
CC[C@H]1/C=C(/[C@H](C/C=C/C=C(/C(=O)O[C@@H](C/C=C(/C=C(/[C@@H]1O[C@H]2[C@H]([C@H]([C@@H](C(O2)(C)C)OC(=O)C(C)C)O)O)\C)\C)[C@@H](C)O)\CO[C@H]3[C@H]([C@H]([C@@H]([C@H](O3)C)OC(=O)C4=C(C(=C(C(=C4O)Cl)O)Cl)CC)O)OC)O)\C
Solubility ( literature )

Reportedly, Fidaxomicin is soluble in CHCl3(10 mg/ml), methanol(10 mg/ml), DMSO(1mg/ml); poor water solubility.

Compound Classification

UNSPSC:

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Other vendors may recommend higher temperatures for storage.
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Transport safety: Not Dangerous Goods; Not Regulated
Available since
Title
depreciated CAS
Value
55352-58-4, 56645-60-4, 750595-89-2
Fermentek Product Category
Antibiotics
Cytotoxic agents
Protein synthesis inhibitors
Anti Bacterial
Research field: Signal Transduction
Signal to sort
F

Quote for

Price
$1.00

Celastrol (Tripterin)

Celastrol (Tripterin)
Molecular Formula
C29H38O4
M.W.
450.61
CAS number
34157-83-0
MSDS
Source
Tripterygium wilfordii
Fermentek product Code
CEL-001
Brand/grade
For research
Appearance
Red powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
190°C-220°C
Solubility test
Clear red solution at 10mg/ml DMSO,
Clear red solution at 10mg/ml Ethanol
Names and identifiers

Synonyms:

  • Tripterin
  • Celastrol

Chemical names:

RTECS: YJ7900000

 
EU number
636-472-5
Description

Celastrol is a chemical compound isolated from the root extracts of Tripterygium wilfordii and Celastrus regelii. Celastrol is a pentacyclic triterpenoid and belongs to the family of quinone methides. In mice, celastrol increases expression of IL1R1, which is the receptor for the cytokine interleukin-1. Celastrol is an antioxidant, anti-inflammatory and immunosuppressive agent. 

InChl Key
KQJSQWZMSAGSHN-JJWQIEBTSA-N
Canonical SMILES
CC1=C(C(=O)C=C2C1=CC=C3C2(CCC4(C3(CCC5(C4CC(CC5)(C)C(=O)O)C)C)C)C)O
Isomeric SMILES
CC1=C(C(=O)C=C2C1=CC=C3C2(CCC4(C3(CCC5(C4CC(CC5)(C)C(=O)O)C)C)C)C)O
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Protect from moisture!
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Shipped in PP / PE bottle.
Transport safety: Not Dangerous Goods; Not Regulated
Available since
Fermentek Product Category
Plant-derived
Enzyme-inhibitors
HSP90 inhibitors
Angiogenesis related
Apoptosis related
Anti Viral
Anti Tumor agents
Research field: Inflamation
Research field: Signal Transduction
Signal to sort
T

Quote for

Price
$10,000.00

Cercosporin

Cercosporin
Molecular Formula
C29H26O10
M.W.
534.51
CAS number
35082-49-6
MSDS
Source
Cercospora kikuchii
Fermentek product Code
CRS-001
Brand/grade
For research
Appearance
Dark red powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
220°C-230°C
Solubility test
Clear red solution at 10mg/ml of DMSO, Clear red solution at 10mg/ml of Methanol
Names and identifiers

Synonyms:

  • Isocercosporin
  • Cercosporin

IUPAC:  5,12-Dihydroxy-8,9-bis[(2R)-2-hydroxypropyl]-7,10-dimethoxyperylo[1,12-def][1,3]dioxepine-6,11-dione 

Chemical names:

RTECS#:  N.A.

EU number
n.a.
Description

Cercosporin is a light-induced polyketide phytotoxin reported to produce singlet oxygen when photoactivated. Acts as a potent and specific PKC inhibitor. Competes for the phorbol binding site. Anticancer compound. Also displays antiproliferative; antiparasitic and antimicrobial properties. Cercosporin is a photosensitizing toxin produced by fungal plant pathogens in the genus Cercospora. Cercosporin produces singlet oxygen and superoxide when irradiated by light, and damages plants by causing a peroxidation of the membrane lipids. This membrane damage leads to a loss in membrane fluidity, leakage of nutrients, and rapid death of the plant cell. Cercosporin is toxic to mice and bacteria in addition to plants, and attempts to select plant cells in vitro for resistance to cercosporin have not been successful. A large number of fungal species, however, are resistant to cercosporin. Carotenoids and the fungal cell wall appear to play a critical role in the resistance of fungi to cercosporin.

InChl Key
MXLWQNCWIIZUQT-NFJWQWPMSA-N
Canonical SMILES
CC(CC1=C(C(=C2C(=O)C=C3C4=C5C(=CC(=O)C6=C(C(=C(C(=C56)C1=C42)CC(C)O)OC)O)OCO3)O)OC)O
Isomeric SMILES
C[C@H](CC1=C(C(=C2C(=O)C=C3C4=C5C(=CC(=O)C6=C(C(=C(C(=C56)C1=C42)CC(C)O)OC)O)OCO3)O)OC)O
Solubility ( literature )
  • Soluble in DMSO, ethanol or methanol (lit)
  • Soluble in 1mg/ml ethanol, methanol, DMSO
  • Soluble in 1mg/liter H2O
  • Melting Point: 241℃ lit - Scifinder
Compound Classification
  • Anticancer agent
  • protein kinase C inhibitor

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Protect from light !
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Transport safety: Not Dangerous Goods; Not Regulated
Available since
Title
MP lit
Value
241°C scifinder; 225-228℃ ; biolinks
Title
LD50 mouse interperitoneal
Value
LD50 >200 mg​/kg i.p. in mice
Title
activity
Value
anticancer agents and protein kinase C inhibitor
Title
comments CAS
Value
There are Cercosporin 35082-49-6 , Iso-Cercosporin 40501-77-7
Title
PG
Value
none. not hazardous.
Fermentek Product Category
Cytotoxic agents
Research field: Cancer
Protein kinase related
Anti Bacterial
Cancer Related Compounds
Anti Tumor agents
Research field: Signal Transduction
Others
Signal to sort
C

Quote for

Price
$100.00

Ophiobolin A

Ophiobolin A
Molecular Formula
C25H36O4
M.W.
400.55
CAS number
4611-05-6
Source
Cochliobolus heterostrophus
Fermentek product Code
OPA-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
171°C-180°C
Solubility test
Clear colorless solution at 10mg/ml of DMSO
Names and identifiers

Synonyms:

  • Ophiobola-7,19-dien-25-al, 14,18-epoxy-3-hydroxy-5-oxo-, (18R)- (8CI)
  • Ophiobolin A
  • Cochliobolin
  • Ophiobolin;
  • Cochliobolin A

IUPAC:

  • (7E,18R)-3-Hydroxy-5-oxo-14,18-epoxyophiobola-7,19-dien-25-al

RTECS# : RL1576000.

EU number
636-934-6
Chemical name
Ophiobolin A
Description

Sesterterpene, natural inhibitor of Calmodulin, exhibiting anti-cancer, antibacterial properties. Phytotoxin from a plant pathogen.

InChl Key
MWYYLZRWWNBROW-BDZRSQQBSA-N
Canonical SMILES
CC1CC(OC12CCC3(C2CC=C(C4C(C3)C(CC4=O)(C)O)C=O)C)C=C(C)C
Isomeric SMILES
C[C@H]1C[C@@H](O[C@@]12CC[C@]3([C@H]2C/C=C(\[C@@H]4[C@H](C3)[C@](CC4=O)(C)O)/C=O)C)C=C(C)C
Solubility ( literature )

Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Store under argon.
Other vendors may recommend higher temperatures for storage.
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped in amber-glass vials
Transport safety: not regulated.
Available since
Title
Deleted CAS numbers
Value
1347-57-5; 5843-70-9; 11022-22-3; 17046-71-8
Title
Toxicity estimation
Value
mouse PO 238mg/kg->category III;
Title
inhibitor-of
Value
CalModulin (calcium-modulated protein
Title
Harmonized code (38220090 Diagnostic or laboratory reagents, CRM)
Value
38220090
Title
Safety:
Value
low PO tox
Title
Transport
Value
Not regulated
Fermentek Product Category
Enzyme-inhibitors
Research field: Cancer
Anti Fungal
Anti Parasitic
Anti Bacterial
Cancer Related Compounds
Anti Tumor agents
Research field: Signal Transduction
Others
Signal to sort
O

Quote for

Price
$75.00

10,11-Dehydrocurvularin

10,11-Dehydrocurvularin
Molecular Formula
C16H18O5
M.W.
290.31
CAS number
21178-57-4
MSDS
Source
Penicillium citrinum
Fermentek product Code
DEH-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
220°C-223°C
Solubility test
Clear colorless solution at 10mg/ml of Methanol
Names and identifiers

Synonyms:

  • Trans-Dehydrocurvularin
  • Dehydrocurvularin
  • 10,11-dehydrocurvularin
  • alpha,beta-Dehydrocurvularin
  • 1095588-70-7

Comment: There are two CAS Registration numbers, corresponding to the name  Dehydrocurvularin.  1095588-70-7, 21178-57-4 These numbers are not "synonyms." The represent two stereo isomers.

Chemical names: 10,11-Dehydrocurvularin

IUPAC:  (5S,9E)-13,15-dihydroxy-5-methyl-4-oxabicyclo[10.4.0]hexadeca-1(12),9,13,15-tetraene-3,11-dione                             

RTECS#

Chemical name
10,11-Dehydrocurvularin
Description

10,11-Dehydrocurvularin is an inhibitor of cell division shown to have antimalarial activity, antibacterial proprerties.

 

InChl Key
AVIRMQMUBGNCKS-RWCYGVJQSA-N
Canonical SMILES
CC1CCCC=CC(=O)C2=C(C=C(C=C2CC(=O)O1)O)O
Isomeric SMILES
C[C@H]1CCC/C=C/C(=O)C2=C(C=C(C=C2CC(=O)O1)O)O
Compound Classification

Natural antibiotic, anti-bacterial, antifungal, phytotoxic.

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Transport safety: Not Dangerous Goods; Not Regulated
Available since
Title
Transport information
Value
Not hazardous for transport.
Fermentek Product Category
Antibiotics
Research field: Cancer
Anti Fungal
Anti Protozoal
Anti Bacterial
Immunomodulators
Research field: Signal Transduction
Signal to sort
D
List price
$5,000.00

Quote for

Price
$1.00
10,11-Dehydrocurvularin
10_11-Dehydrocurvularin
10,11-Dehydrocurvularin
10_11-Dehydrocurvularin

alpha Zearalanol

alpha Zearalanol
Molecular Formula
C18H26O5
M.W.
322.40
CAS number
26538-44-3
MSDS
Source
Semisynthetic
Fermentek product Code
ZAL-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
180°C-185°C
Solubility test
Clear colorless solution at 10mg/ml of Methanol
Names and identifiers

Synonyms:      Zeranol;    α-Zearalanol; 

Chemical names:   

IUPAC: 6-(6,10-Dihydroxyundecyl)-beta-resorcylic acid, mu-lactone;

RTECS#  DM2520000

EU number
247-769-0
Description

Alpha-Zearalanol is a minor analogue of the zearalenone family of mycotoxins.

InChl Key
DWTTZBARDOXEAM-TZMCWYRMSA-N
Canonical SMILES
CC1CCCC(CCCCCC2=CC(=CC(=C2C(=O)O1)O)O)O
Isomeric SMILES
C[C@@H]1CCC[C@@H](CCCCCC2=CC(=CC(=C2C(=O)O1)O)O)O
Compound Classification

Macrolide.

Mycotoxin - Zearalenone group

Fito-estrogen

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Applications

Phytoestrogen alpha-zearalanol  improves vascular function  in  ovariectomized  hyperhomocvsteinemic  rats. 

 

 

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Transport safety: Not Dangerous Goods; Not Regulated
Available since
Title
Transport information
Value
Not hazardous for transport
Title
Deleted CAS Registry Numbers
Value
5975-81-5 | 21307-30-2 | 24507-00-4 | 39487-91-7 | 40036-43-9
Fermentek Product Category
Food Safety
Mycotoxins
Food Safety Related
Other mycotoxins
Antibiotics
Cytotoxic agents
Enzyme-inhibitors
Research field: Cancer
Anti Fungal
Immunomodulators
Research field: Signal Transduction
Signal to sort
A

Quote for

Price
$1.00

Chaetocin

Chaetocin
Molecular Formula
C30H28N6O6S4
M.W.
696.84
CAS number
28097-03-2
Source
From Chaetomium sp
Fermentek product Code
CHT-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥95% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
247°C-253°C
Solubility test
Clear colorless solution at 25 mg/ml DMSO
Names and identifiers

Synonyms

  • Chetocin
  • Chaetocin
  • (3S,3'S,5aR,5aR,10bR,10'bR,11aS,11'aS)-2,2',3,3',5a,5'a,6,6'-octahydro-3,3'-bis(hydroxymethyl)-2,2'-dimethyl-[10b,10'b(11H,11'H)-bi3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole]-1,1',4,4'-tetrone

RTECS: FM3032000

EU number
636-696-3
Description

A fungal metabolite which inhibits G9a histone methyltransferase.

InChl Key
PZPPOCZWRGNKIR-PNVYSBBASA-N
Canonical SMILES
CN1C(=O)C23CC4(C(N2C(=O)C1(SS3)CO)NC5=CC=CC=C54)C67CC89C(=O)N(C(C(=O)N8C6NC1=CC=CC=C71)(SS9)CO)C
Isomeric SMILES
c12c(N[C@@H]3N4[C@@]5(C[C@@]23[C@@]23c6c(N[C@@H]2N2[C@@]7(C3)C(N([C@@](C2=O)(SS7)CO)C)=O)cccc6)C(N([C@@](CO)(C4=O)SS5)C)=O)cccc1
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Deleted CAS Numbers:
Value
31794-18-0
Title
Inhibitor of:
Value
G9a histone methyltransferase
Title
Transport information
Value
Not hazardous for transport
Title
Research Areas
Value
HIV
Fermentek Product Category
Food Safety
Mycotoxins
Food Safety Related
Other mycotoxins
Enzyme-inhibitors
Research field: Cancer
Apoptosis related
Research field: Signal Transduction
Signal to sort
C

Quote for

Price
$1.00

Epigallocatechin Gallate

Epigallocatechin Gallate
Molecular Formula
C22H18O11
M.W.
458.40
CAS number
989-51-5
Source
Extracted from Green Tea (leaves)
Fermentek product Code
EPG-001
Brand/grade
For research
Appearance
White to Beige lyophilized powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10 mg/ml H2O
Names and identifiers

RTECS KB5200000

EU number
619-381-5
Chemical name
[(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate
Description

Epigallocatechin is a phenolic antioxidant found in a number of plants such as green and black tea.
Epigallocatechin inhibits cellular oxidation and prevents free radical damage to cells. 

 

InChl Key
WMBWREPUVVBILR-WIYYLYMNSA-N
Canonical SMILES
C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O
Isomeric SMILES
C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O
Compound Classification

- Antioxidant

- Potential cancer-preventive agent. 

- Inhibitor of Telomerase

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Applications

Epigallocatechin is being studied as a potential cancer chemo preventive agent.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Fermentek Product Category
Plant-derived
Enzyme-inhibitors
Research field: Cancer
Protein kinase related
Research field: Signal Transduction
Signal to sort
E

Quote for

Price
$1.00
Subscribe to Research field: Signal Transduction