Roridin A

Roridin A
Molecular Formula
C29H40O9
M.W.
532.62
CAS number
14729-29-4
Source
Myrothecium sp.
Fermentek product Code
ROA-001
Brand/grade
For research
Appearance
White to faint yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless to faint yellow solution at 10mg/ml of DMSO or Chloroform
Names and identifiers

 

Synonyms:

  • Verrucarin A, 7'-deoxo-7'-(1-hydroxyethyl)-
  • Roridin A
  • Roridan A
  • Antibiotic 379X

IUPAC:

(1'R,3'R,8'R,12'S,13'R,17'R,18'E,20'Z,24'R,25'S)-12'-Hydroxy-17'-[(1R)-1-hydroxyethyl]-5',13',25'-trimethyl-11'H,22'H-spiro[oxirane-2,26'-[2,10,16,23]tetraoxatetracyclo[22.2.1.03,8.08,25]heptacosa ;[4,18,20]triene]-11',22'-dione

RTECS# VL0355000

EU number
238-783-8
Description

A type D trichothecene mycotoxin exhibiting anticancer properties

InChl Key
NSFWWJIQIKBZMJ-PAGWOCKZSA-N
Canonical SMILES
CC1CCOC(C=CC=CC(=O)OC2CC3C4(C2(C5(CCC(=CC5O3)C)COC(=O)C1O)C)CO4)C(C)O
Isomeric SMILES
C[C@@H]1CCO[C@H](/C=C/C=C\C(=O)O[C@@H]2C[C@@H]3[C@]4([C@]2([C@]5(CCC(=C[C@H]5O3)C)COC(=O)[C@H]1O)C)CO4)[C@@H](C)O
Compound Classification

Type D Thrichthecene.

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Other vendors may recommend higher temperatures for storage.
Protect from moisture!
Applications

Roridin A and other Roridins and Verrucarins are produced by "The Black Mold", a common name for Stachybotrys family of molds that infect houses. Exposure to Roridin A can cause nasal irritation, abundance bodily fluid emission, and harm to the olfactory framework. Gastrointestinal exposure to Roridins can cause ulceration or bleeding from the large intestine, hypermotility, diarrhea. Long-term exposure to Roridins has been reported to cause cognitive disorders.

Roridin A from Fermentek is manufactured using a Myrothecium mold (which belongs to the Stachybotrys family). It is used as a sample to detect Black Mold infection in houses.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature

Prodigiosin hydrochloride

Prodigiosin hydrochloride
Molecular Formula
C20H25N3O·HCl
M.W.
359.89
CAS number
56144-17-3
MSDS
Source
Serratia marcescens
Fermentek product Code
PRD-001
Brand/grade
For research
Appearance
Dark Red powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear red solution at 10mg/ml of Methanol, Clear red solution at 10mg/ml of DMSO
Names and identifiers

Synonyms:

Disambiguation:    Do not confuse with Prodigiozan, another antibiotic from the same source.

Chemical names:   2,​2'-​Bi-​1H-​pyrrole, 4-​methoxy-​5-​[(5-​methyl-​4-​pentyl-​2H-​pyrrol-​2-​ylidene)​methyl]​-​, hydrochloride (1:1)

IUPAC:                    (2Z)-3-methoxy-2-[(5-methyl-4-pentyl-1H-pyrrol-2-yl)methylidene]-5-(1H-pyrrol-2-yl)pyrrole;hydrochloride

RTECS                     DW2977000   refers to prodigiosin free base 

EU number
Not listed
Chemical name
4-Methoxy-5-[(E)-(5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl]-1H,1'H-2,2'-bipyrrole
Merck index
14: 7767
Description

Prodigiosin is a antibiotic from Serratia marcescens and some other bacterial species. It displays a wide range of biological activities, making it a promissing candidate drug. Among these are antimalarial, antifungal, anti-cancer, immunosuppressant, and antibiotic properties.

InChl Key
UQRGJSTXVCWXNU-JHMJKTBASA-N
Canonical SMILES
CCCCCC1=C(NC(=C1)C=C2C(=CC(=N2)C3=CC=CN3)OC)C.Cl
Isomeric SMILES
CCCCCC1=C(NC(=C1)/C=C/2\C(=CC(=N2)C3=CC=CN3)OC)C.Cl
Solubility ( literature )

(Data from literature including scientific publications and books, patents and other vendors)

Prodigiosin is soluble in acetonitrile, ethanol, methanol, chloroform, and DMSO. It is insoluble in water.

Compound Classification

UNSPSC

  • 51000000  Drugs and Pharmaceutical Products
  • 51200000  Immunomodulating drugs
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Other vendors may recommend higher temperatures for storage.
Applications

For research only!

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped in amber-glass vials
Transport safety: Not Dangerous Goods; Not Regulated
Transport safety: not regulated.
Available since

Bafilomycin B1

Bafilomycin B1
Molecular Formula
C44H65NO13
M.W.
816.00
CAS number
88899-56-3
Source
Streptomyces sp.
Fermentek product Code
BFB-001
Brand/grade
For research
Appearance
Yellow powder
Purity by HPLC
≥95% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear yellow solution at 5mg/ml Methanol ;
Clear yellow solution at 5mg/ml DMSO ;
Names and identifiers

Synonyms

  • Hygrolidin, 37-decarboxy-2-demethyl-37-[[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]carbonyl]-2-methoxy-24-methyl
  • Setamycin
  • Bafilomycin B1

IUPAC Name

  • (5R)-2,4-Dideoxy-1-C-{(2S,3R,4S)-3-hydroxy-4-[(3S,4Z,9S,10S,11R)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-2-pentanyl}-3-O-{(2E)-4-[(2-hydroxy-5-ox ;o-1-cyclopenten-1-yl)amino]-4-oxo-2-butenoyl}-5-isopropyl-4-methyl-α-D-threo-pentopyranose

 RTECS: NG8841000

EU number
635-481-1
Chemical name
Bafilomycin B1
Description

Bafilomycin B1 is a specific inhibitor of vacuolar type H+-ATPase (V-ATPase) in animal cells, plant cells and microorganisms.

Bafilomycin B1  can prevent the re-acidification of synaptic vesicles once they have undergone exocytosis.

It displays Antibacterial, Antifungal, Antineoplastic, Immunosuppressive properties.

Bafilomycin B1 shares the same mode of action and activity as its more accessible Bafilomycin A1 analogue. Bafilomycin B1 is broadly active against bacteria, fungi, insects, nematodes and protozoans. Bafilomycin B1 has attracted interest as a potential antiosteoporotic agent in treating bone lytic diseases.

Bafilomycins have been considered as possible therapeutic agents in the treatment of gastritis.

InChl Key
KFUFLYSBMNNJTF-MZYUNMTESA-N
Canonical SMILES
CC1CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C(C)C)C)OC(=O)C=CC(=O)NC3=C(CCC3=O)O)O)O)OC)C
Isomeric SMILES
C[C@H]1C/C(=C\C=C/[C@@H](C(OC(=O)/C(=C\C(=C/[C@H]([C@H]1O)C)\C)/OC)[C@@H](C)[C@H]([C@H](C)[C@]2(C[C@H]([C@@H]([C@H](O2)C(C)C)C)OC(=O)/C=C/C(=O)NC3=C(CCC3=O)O)O)O)OC)/C
Solubility ( literature )

Reportedly soluble in ethanol, methanol, DMF or DMSO. Attention: may form methyl ketal on long term storage in methanol

Compound Classification

Macrolide antibiotic

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Use the original container to store the product.
Keep the lid tightly closed.
Store under argon.
shipped at ambient temperature. Stored under inert atmosphere.
Applications

Bafilomycins specificly  inhibit  vacuolar type H+-ATPase (V-ATPase) in animal cells, plant cells and microorganisms. Bafilomycin A1 is useful in distinguishing among different types of ATPases. Bafilomycin A1 can prevent the re-acidification of synaptic vesicles once they have undergone exocytosis. Bafilomycin A1 and B1 significantly attenuate cerebellar granule neuron death resulting from agents that disrupt lysosome. As vacuolar ATPase inhibitors bafilomycins overcome Bcl-​xL-​mediated chemoresistance through restoration of a caspase-​independent apoptotic pathway.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
II or III but basic information is not credible, no quantitative data available
Title
Deleted CAS Numbers
Value
80112-34-1; used with name Setamycin only
Signal to sort
B

Ophiobolin A

Ophiobolin A
Molecular Formula
C25H36O4
M.W.
400.55
CAS number
4611-05-6
Source
Cochliobolus heterostrophus
Fermentek product Code
OPA-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
171°C-180°C
Solubility test
Clear colorless solution at 10mg/ml of DMSO
Names and identifiers

Synonyms:

  • Ophiobola-7,19-dien-25-al, 14,18-epoxy-3-hydroxy-5-oxo-, (18R)- (8CI)
  • Ophiobolin A
  • Cochliobolin
  • Ophiobolin;
  • Cochliobolin A

IUPAC:

  • (7E,18R)-3-Hydroxy-5-oxo-14,18-epoxyophiobola-7,19-dien-25-al

RTECS# : RL1576000.

EU number
636-934-6
Chemical name
Ophiobolin A
Description

Sesterterpene, natural inhibitor of Calmodulin, exhibiting anti-cancer, antibacterial properties. Phytotoxin from a plant pathogen.

InChl Key
MWYYLZRWWNBROW-BDZRSQQBSA-N
Canonical SMILES
CC1CC(OC12CCC3(C2CC=C(C4C(C3)C(CC4=O)(C)O)C=O)C)C=C(C)C
Isomeric SMILES
C[C@H]1C[C@@H](O[C@@]12CC[C@]3([C@H]2C/C=C(\[C@@H]4[C@H](C3)[C@](CC4=O)(C)O)/C=O)C)C=C(C)C
Solubility ( literature )

Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Store under argon.
Other vendors may recommend higher temperatures for storage.
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped in amber-glass vials
Transport safety: not regulated.
Available since
Title
Deleted CAS numbers
Value
1347-57-5; 5843-70-9; 11022-22-3; 17046-71-8
Title
Toxicity estimation
Value
mouse PO 238mg/kg->category III;
Title
inhibitor-of
Value
CalModulin (calcium-modulated protein
Title
Harmonized code (38220090 Diagnostic or laboratory reagents, CRM)
Value
38220090
Title
Safety:
Value
low PO tox
Title
Transport
Value
Not regulated
Signal to sort
O

Fumagillin

Fumagillin
Molecular Formula
C26H34O7
M.W.
458.54
CAS number
23110-15-8
MSDS
Source
Aspergillus fumigatus
Fermentek product Code
FUG-001
Appearance
Off-white to slight yellow powder
Purity by HPLC
≥95% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
190°C-202°C
Solubility test
Clear colorless solution at 30mg/ml DMSO,
Clear colorless solution at 1mg/ml Ethanol
Names and identifiers

Synonyms:

  • Fumidil B,
  • Amebacilin,

IUPAC Name   (2E,4E,6E,8E)-10-({(3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl}oxy)-10-oxo-2,4,6,8-decatetraenoic acid 

RTECS :             HE1750000

EU number
245-433-8
Description

Antiamoebic. Inhibitor of angiogenesis.

Reproduction effector

InChl Key
NGGMYCMLYOUNGM-CSDLUJIJSA-N
Canonical SMILES
CC(=CCC1C(O1)(C)C2C(C(CCC23CO3)OC(=O)C=CC=CC=CC=CC(=O)O)OC)C
Isomeric SMILES
CC(=CC[C@@H]1[C@@](O1)(C)[C@H]2[C@@H]([C@@H](CC[C@]23CO3)OC(=O)/C=C/C=C/C=C/C=C/C(=O)O)OC)C
Solubility ( literature )

DMSO, Methanol. alkaline aqueous solutions

Compound Classification

Chemical classification:

Fatty acid antibiotic.

Classification by bio-activity

Antiprotozoal

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Avoid exposing to strong direct light.
Store under argon.
Other vendors may recommend higher temperatures for storage.
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Transport safety: Not Dangerous Goods; Not Regulated
Available since
Title
Transport information
Value
Not hazardous for transport
Signal to sort
F