Roridin A
Molecular Formula
C29H40O9
M.W.
532.62
CAS number
14729-29-4
Source
Myrothecium sp.
Fermentek product Code
ROA-001
Brand/grade
For research
Appearance
White to faint yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless to faint yellow solution at 10mg/ml of DMSO or Chloroform
Names and identifiers

 

Synonyms:

  • Verrucarin A, 7'-deoxo-7'-(1-hydroxyethyl)-
  • Roridin A
  • Roridan A
  • Antibiotic 379X

IUPAC:

(1'R,3'R,8'R,12'S,13'R,17'R,18'E,20'Z,24'R,25'S)-12'-Hydroxy-17'-[(1R)-1-hydroxyethyl]-5',13',25'-trimethyl-11'H,22'H-spiro[oxirane-2,26'-[2,10,16,23]tetraoxatetracyclo[22.2.1.03,8.08,25]heptacosa ;[4,18,20]triene]-11',22'-dione

RTECS# VL0355000

EU number
238-783-8
Description

A type D trichothecene mycotoxin exhibiting anticancer properties

InChl Key
NSFWWJIQIKBZMJ-PAGWOCKZSA-N
Canonical SMILES
CC1CCOC(C=CC=CC(=O)OC2CC3C4(C2(C5(CCC(=CC5O3)C)COC(=O)C1O)C)CO4)C(C)O
Isomeric SMILES
C[C@@H]1CCO[C@H](/C=C/C=C\C(=O)O[C@@H]2C[C@@H]3[C@]4([C@]2([C@]5(CCC(=C[C@H]5O3)C)COC(=O)[C@H]1O)C)CO4)[C@@H](C)O
Compound Classification

Type D Thrichthecene.

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Other vendors may recommend higher temperatures for storage.
Protect from moisture!
Applications

Roridin A and other Roridins and Verrucarins are produced by "The Black Mold", a common name for Stachybotrys family of molds that infect houses. Exposure to Roridin A can cause nasal irritation, abundance bodily fluid emission, and harm to the olfactory framework. Gastrointestinal exposure to Roridins can cause ulceration or bleeding from the large intestine, hypermotility, diarrhea. Long-term exposure to Roridins has been reported to cause cognitive disorders.

Roridin A from Fermentek is manufactured using a Myrothecium mold (which belongs to the Stachybotrys family). It is used as a sample to detect Black Mold infection in houses.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature