Ionophores are compounds which can facilitate the migration of ions across biological membranes. Ions, being electrically charged, cannot by themselves cross the hydrophobic interior of biological membranes.

Ionophores usually have a polar inner moiety, and a non-polar outer moiety which can span or cross the hydrophobic interior of the membrane. Ionophore function usually affects metallic cations.

There are two types of ionophores: Channel-formers and Carriers. Channel formers are usually large proteins. They usually function by incorporating themselves into the cell-membrane, creating a polar “tube” across the membrane, enabling ions pass through. Carriers are usually smaller molecules, with a non-polar exterior and a polar interior.

The polar interior can reversibly bind an ion, effectively wrapping the electric charge of the ion within a non-polar envelope. The non-polar envelope can then cross the interior of the membrane, carrying the ion with it.

Ionophores can interfere with the balance of ion concentrations across membranes. Maintenance of ionic gradients across the cell membrane is an essential biological function. In interfering with such ionic gradients, ionophores often display antibiotic properties. Several novel works have been published, where natural ionophore compounds, when fed to cattle in liquid, solid or medicinal form, increased calf weight gain in correlation to the amount given.

Nigericin (free)

Nigericin (free)
Molecular Formula
C40H68O11
M.W.
724.96
CAS number
28380-24-7
Source
Streptomyces hygroscopicus
Fermentek product Code
NIG-002
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
180-190°C
Solubility test
Clear colorless solution at 10mg/ml of
Dichloromethane
or Methanol
or Ethyl acetate
or Water
Names and identifiers

Synonyms: 

Polyetherin A; Azalomycin M; Helexin C ; Antibiotic K178;  Antibiotic X-464

Chemical names:

IUPAC:

(2R)-2-[(2R,3S,6R)-6-[[(2S,4R,5R,6R,7R,9R)-2-[(2R,5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyloxan-2-yl]propanoic acid  

RTECS# QT6825000

EU number
686-881-8
Chemical name
Polyetherin A; Azalomycin M; Helexin C ; Antibiotic K178; Antibiotic X-464
Description

Nigericin is a polyether antibiotic which affects ion transport and ATPase activity in mitochondria.

Nigericin is produced by Streptomyces hygroscopicus. Nigericin, an ionophore and antibiotic, is supplied as a free acid. It is also available as a Na salt.sodium salt.

Nigericin is one of the compounds successfully tested as a feed additive, displaying a significant effect on milk production in cattle. In vitro, nigericin has broad biological activity against Gram positive bacteria, fungi, tumor cell lines and some viruses, including HIV.

InChl Key
DANUORFCFTYTSZ-SJSJOXFOSA-N
Isomeric SMILES
C[C@H]1CC[C@@H](O[C@H]1[C@@H](C)C(=O)O)C[C@@H]2C[C@H]([C@H]([C@@]3(O2)[C@@H](C[C@@](O3)(C)[C@H]4CC[C@@](O4)(C)[C@H]5[C@H](C[C@@H](O5)[C@@H]6[C@H](C[C@H]([C@@](O6)(CO)O)C)C)C)C)C)OC
Solubility ( literature )

DMSO, Ethanol, petrol ether. Not soluble in water

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Applications

Disrupts the membrane potential and stimulates ATPase activity in mitochondria.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Fermentek Product Category
Antibiotics
Research field: Cancer
Ionophores

Quote for

Price
$1.00
Nigericin (free)
Nigericin (free)

Salinomycin

Salinomycin
Molecular Formula
C42H70O11
M.W.
751.00
CAS number
53003-10-4
MSDS
Source
Streptomyces sp.
Fermentek product Code
SAL-001
Brand/grade
For research
Appearance
White to slightly yellow lyophilizated powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml of DMSO
Names and identifiers

Synonyms:

  • Procoxacin
  • Coxistac
  • Antibiotic 61477

Chemical names:

IUPAC:

(2R)-2-{(2R,5S,6R)-6-[(2S,3S,4S,6R)-6-{(2S,5S,7R,9S,10S,12R,15R)-2-[(2R,5R,6S)-5-Ethyl-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13- en-9-yl}-3-hydroxy-4-methyl-5-oxo-2-octanyl]-5-methyltetrahydro-2H-pyran-2-yl}butanoic acid

RTECS# VO8620000

 
EU number
258-290-1
Chemical name
Salinomycin
Description

A polyether potassium ionophore. Salinomycin is potent antimicrobial, it acts against Gram-positive bacteria, among which there are some hard to treat strains, for example  methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus epidermidis, and Mycobacterium tuberculosis. 

As an anticancer candidate drug, Salinomycin has been shown by Piyush Gupta et al. of the Massachusetts Institute of Technology and the Broad Institute to kill breast cancer stem cells in mice at least 100 times more effectively than the anti-cancer drug paclitaxel. The study screened 16,000 different chemical compounds and found that only a small subset, including salinomycin and etoposide, targeted cancer stem cells responsible for metastasis and relapse.

 

 

InChl Key
KQXDHUJYNAXLNZ-XQSDOZFQSA-N
Canonical SMILES
CCC(C1CCC(C(O1)C(C)C(C(C)C(=O)C(CC)C2C(CC(C3(O2)C=CC(C4(O3)CCC(O4)(C)C5CCC(C(O5)C)(CC)O)O)C)C)O)C)C(=O)O
Isomeric SMILES
CC[C@H]([C@@H]1[C@H](C[C@H]([C@@]2(O1)C=C[C@H]([C@]3(O2)CC[C@@](O3)(C)[C@H]4CC[C@@]([C@@H](O4)C)(CC)O)O)C)C)C(=O)[C@@H](C)[C@H]([C@H](C)[C@H]5[C@H](CCC(O5)[C@@H](CC)C(=O)O)C)O
Solubility ( literature )

Reported to be soluble in methanol (10 mg/mL)

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Expiration time
3Y
Retest time
2Y
Applications

While "For Agriculture" grade of Salinomycin is used as poultry feed additive, Fermentek's "For Research" grade Salinomycin is directed for experimental anti-cancer drugs development. The most prominent property of Salinomycin is to selectively cause apoptosis in Glioblastoma Stem Cells.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg III
Title
reach
Value
On REACH List of Pre-Registered Substances, March 2009 Registration Date: 31-MAY-2013.
Title
EU Customs Code CN
Value
29419000
Title
Harmonized Tariff Code
Value
294190
Title
general comment
Value
there is Na Salinomycin w cas 55721-31-8
Title
toxicity by RTECS
Value
LD50 oral mouse 50 mg/kg
Title
Deleted CAS Registry Numbers
Value
37362-39-3 ; 50863-72-4
Fermentek Product Category
Antibiotics
Research field: Cancer
Apoptosis related
Anti Protozoal
Anti Bacterial
Cancer Related Compounds
Anti Tumor agents
Research Area: Stem Cells
Ionophores
Signal to sort
S

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Price
$20.00

Enniatin A1

Enniatin A1
Molecular Formula
C35H61N3O9
M.W.
667.87
CAS number
4530-21-6
Source
Fusarium sp
Fermentek product Code
ENA-002
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml of DMSO or Methanol
Names and identifiers

Synonyms:

Chemical names: Enniatin A1

IUPAC: 3S,6R,9S,12R,15S,18R)-3,9-bis[(2S)-butan-2-yl]-4,10,16-trimethyl-6,12,15,18-tetra(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone

IUPAC, Biological notation: cyclo[N(Me)Ile-D-OVal-N(Me)Ile-D-OVal-N(Me)Val-D-OVal]

 
EU number
215-737-5
Description

Enniatin A1 has been found to induce apoptosis in cancer cells ...

InChl Key
OWUREPXBPJFMOK-CIRFPNLUSA-N
Canonical SMILES
CCC(C)C1C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N1C)C(C)C)C(C)C)C)C(C)C)C(C)CC)C)C(C)C
Isomeric SMILES
CC[C@H](C)[C@H]1C(=O)O[C@@H](C(=O)N([C@H](C(=O)O[C@@H](C(=O)N([C@H](C(=O)O[C@@H](C(=O)N1C)C(C)C)[C@@H](C)CC)C)C(C)C)C(C)C)C)C(C)C
Compound Classification

Chemical Classification:

Cyclodepsipeptide

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Fermentek Product Category
Food Safety
Mycotoxins
Food Safety Related
Other mycotoxins
Enzyme-inhibitors
Ionophores
Signal to sort
E

Quote for

Price
$1.00

Enniatin A

Enniatin A
Molecular Formula
C36H63N3O9
M.W.
681.90
CAS number
2503-13-1
Source
Fusarium sp.
Fermentek product Code
ENA-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
121°C-125°C
Solubility test
Clear colorless solution at 10mg/ml of Dichloromethane or Methanol
Names and identifiers

Synonyms:

Chemical names:  Fusafungine ;   Enniatin-A

IUPAC: (3S,9S,12R,15S,18R)-9,15-bis[(2S)-butan-2-yl]-3-[(2R)-butan-2-yl]-4,10,16-trimethyl-6,12,18-tri(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone

A Fusarium produced depsipeptide ionophore

RTECS#  

Condensed IUPAC:  cyclo[N(Me)Ile-D-OVal-N(Me)Ile-DL-OVal-N(Me)aIle-D-OVal]

EU number
215-737-5
Description

Enniatin A is a least abundant commponent of the Enniatin-complex. It has been recently made available as a pure compound, thanks to the most advanced preparative HPLC methods.

InChl Key
TWHBYJSVDCWICV-BHZTXFQCSA-N
Canonical SMILES
CCC(C)C1C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N1C)C(C)C)C(C)CC)C)C(C)C)C(C)CC)C)C(C)C
Isomeric SMILES
CC[C@H](C)[C@H]1C(=O)O[C@@H](C(=O)N([C@H](C(=O)O[C@@H](C(=O)N([C@H](C(=O)O[C@@H](C(=O)N1C)C(C)C)[C@@H](C)CC)C)C(C)C)[C@@H](C)CC)C)C(C)C
Solubility ( literature )

Soluble in ethanol, methanol, DMSO, DMF.

Compound Classification

Chemical classification:  Cyclic depsipeptide.

Biological classification:

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Applications

Natural enniatins occure as a mixture of several related analogs, known as "Enniatins", or "Enniatin complex". 

Enniatins occure in nature in the mycelia of some Fusarium species. Being cyclic and hydrophopic molecules, enniatins are able to act as ionophores. More recently their effects on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumor action have received more focus. Enniatin has not previously been available for investigation.

 

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg III
Title
Deleted CAS Numbers
Value
2503-13-1; 4530-29-4
Fermentek Product Category
Food Safety
Mycotoxins
Food Safety Related
Other mycotoxins
Enzyme-inhibitors
Research field: Cancer
Apoptosis related
Protein kinase related
Immunomodulators
Ionophores
Signal to sort
E

Quote for

Price
$1.00

Enniatin B1

Enniatin B1
Molecular Formula
C34H59N3O9
M.W.
653.85
CAS number
19914-20-6
Source
Fusarium sp.
Fermentek product Code
ENB-002
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml of Dichloromethane or Methanol
Names and identifiers

Synonyms:
2-(N-Methyl-L-isoleucine)enniatin B 

Chemical names:

IUPAC NAME:
3-butan-2-yl-4,10,16-trimethyl-6,9,12,15,18-penta(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone

RTECS#  n.a.

 

Description

Enniatin B1 has been shown to induce apoptosis in several cancer lines and to decrease the activation of the cell proliferation kinase, ERK (p44/p42).
Enniatin B1also is being used in research on drug resistance mechanisms.

InChl Key
UQCSETXJXJTMKO-UMURLBKASA-N
Canonical SMILES
CCC(C)C1C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N1C)C(C)C)C(C)C)C)C(C)C)C(C)C)C)C(C)C
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Protect from moisture!
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
PG III
Fermentek Product Category
Food Safety
Mycotoxins
Food Safety Related
Ionophores
Signal to sort
E

Quote for

Price
$1.00

Enniatin B

Enniatin B
Molecular Formula
C33H57N3O9
M.W.
639.82
CAS number
917-13-5
Source
Fusarium sp.
Fermentek product Code
ENB-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
172°C-176°C
Solubility test
Clear colorless solution at 10mg/ml of Dichloromethane or Methanol
Names and identifiers

Synonyms:

Chemical names:

IUPAC:

(3S,6R,9S,12R,15S,18R)-4,10,16-trimethyl-3,6,9,12,15,18-hexa(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone

IUPAC Condensed name, as an oligopeptide
cyclo[N(Me)Val-D-OVal-N(Me)Val-D-OVal-N(Me)Val-D-OVal]

RTECS n.a.

Description

Enniatin B is the most studied of four major analogues of the enniatin complex.

InChl Key
MIZMDSVSLSIMSC-VYLWARHZSA-N
Canonical SMILES
CC(C)C1C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N1C)C(C)C)C(C)C)C)C(C)C)C(C)C)C)C(C)C
Isomeric SMILES
CC(C)[C@H]1C(=O)O[C@@H](C(=O)N([C@H](C(=O)O[C@@H](C(=O)N([C@H](C(=O)O[C@@H](C(=O)N1C)C(C)C)C(C)C)C)C(C)C)C(C)C)C)C(C)C
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Fermentek Product Category
Food Safety
Mycotoxins
Food Safety Related
Other mycotoxins
Enzyme-inhibitors
Research field: Cancer
Ionophores
Signal to sort
E

Quote for

Price
$1.00

Enniatin (complex)

Enniatin (complex)
Molecular Formula
C33H57N3O9
M.W.
639.80
CAS number
11113-62-5
Source
Fusarium sp
Fermentek product Code
ENC-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% as complex ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml Dichloromethane
or Methanol
Names and identifiers

Synonyms:
Enniatins

Chemical names:
Enniatin complex;

IUPAC:
4,10,16-trimethyl-3,6,9,12,15,18-hexa(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone

RTECS : n.a.
 

 

Description

Enniatins are a family of depsipeptides produced by several species of Fusaria. Enniatins have initially been shown to act as ionophores. Later, their effects on acyl-CoA cholesterol transferase, ABC-transporters and the selectivity of their antitumor action are emphasized in the research.

InChl Key
MIZMDSVSLSIMSC-OGLSAIDSSA-N
Canonical SMILES
CC(C)[C@H]1C(=O)OC(C(=O)N([C@H](C(=O)OC(C(=O)N([C@H](C(=O)OC(C(=O)N1C)C(C)C)C(C)C)C)C(C)C)C(C)C)C)C(C)C
Compound Classification

Depsipeptide antibiotic.

Ammonium Ionophore.

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Applications

Mentioned as a replacement for Nonactin, in manufacturing on ammonium specific electrodes.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Food Safety
Mycotoxins
Food Safety Related
Research field: Cancer
Protein synthesis inhibitors
Anti Protozoal
Ionophores
Signal to sort
E

Quote for

Price
$1.00

A23187 Ca-Mg

A23187 Ca-Mg
CAS number
This mixture has no CAS number assigned to it.
Source
Semisynthetic
Fermentek product Code
ACM-001
Brand/grade
For research
Appearance
White powder
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
280°C-305°C
Solubility test
Clear colorless solution at 10mg/ml Dichloromethane
Description

Mixed Calcium-Magnesium salt of A23187 (Calcimycin) is prepared chemically from A23187 (Calcimycin).

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend +3 to +8°C storage.
Retest time
3Y
Applications

Used in cell activation experiments when calcium dose-response data are not required.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient Other
(A23187)2 Mg
Ingredient type
Fermentek product
Ingredient amount
50%
Ingredient Other
(A23187)2 Ca;
Ingredient type
Fermentek product
Ingredient amount
50%
Title
Transport information
Value
Not hazardous for transport
Title
sig
Value
100106
Title
TSE category
Value
S
Title
TSE category
Value
S
Fermentek Product Category
Antibiotics
Cytotoxic agents
Ionophores
Signal to sort
A

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Price
$1.00

Valinomycin

Valinomycin
Molecular Formula
C54H90N6O18
M.W.
1 111.32
CAS number
2001-95-8
MSDS
Source
Streptomyces fulvissimus
Fermentek product Code
VAL-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥96% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
186°C-190°C
Solubility test
Clear colorless solution at 50mg/ml Dicloromethane or DMSO
Names and identifiers

Synonyms: Potassium ionophore I

HSDB: 6423

EINECS: 217-896-6

RTECS: YV9468000

EU number
217-896-6
Description

Valinomycin is a cyclododecadepsipeptide ionophore antibiotic produced by Streptomyces fulvissimus and chemically related to the enniatins.

 

InChl Key
FCFNRCROJUBPLU-UHFFFAOYSA-N
Canonical SMILES
CC1C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)O1)C(C)C)C(C)C)C(C)C)C)C(C)C)C(C)C)C(C)C)C)C(C)C)C(C)C)C(C)C
Isomeric SMILES
C[C@H]1C(=O)N[C@H](C(=O)O[C@@H](C(=O)N[C@@H](C(=O)O[C@H](C(=O)N[C@H](C(=O)O[C@@H](C(=O)N[C@@H](C(=O)O[C@H](C(=O)N[C@H](C(=O)O[C@@H](C(=O)N[C@@H](C(=O)O1)C(C)C)C(C)C)C(C)C)C)C(C)C)C(C)C)C(C)C)C)C(C)C)C(C)C)C(C)C
Compound Classification

cyclic oligopeptide Ionophore

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Other vendors may recommend higher temperatures for storage.
Applications

Being a Potassium selective ionophore, valinomycin is used in specific potassium measurment electrodes.Valinomycin is an apoptosis inducer. It is used as a tool in membrane research.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Hazard. Pg I
Title
Deleted CAS numbers
Value
134-16-7; 11005-80-4; 32398-05-3
Title
Inventory Status canada
Value
On NDSL Canada Gazette, Part I, January 31, 1998
Title
regulatory india
Value
List of Hazardous Chemicals, 2000.
Title
regulatory USA
Value
40 CFR Part 302 ; 40 CFR Part 355
Fermentek Product Category
Antibiotics
Anti Bacterial
Ionophores
Signal to sort
V

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Price
$1.00

Nonactin

Nonactin
Molecular Formula
C40H64O12
M.W.
736.93
CAS number
6833-84-7
Source
Streptomyces griseus var griseus
Fermentek product Code
NON-001
Brand/grade
For research
Appearance
White needle-like crystals.
Purity by HPLC
≥98% ; refer to CoA for more data
Melting point
145°C-146°C
Crystallinity
Crystalline
Solubility test
Clear colorless solution at 10mg/ml Dichloromethane or 10mg/ml DMSO


Names and identifiers
  • Ammonium Ionophore.
  • Werramycin-A.
  • Polynactin

RTECS: RH1685000

EU number
229-911-3
Description

Nonactin from Streptomyces Griseus: a mixture of the two homolog macrotetrolide antibiotics: Nonactin, Monactin. Nonactin is not less than 80%, ballanced by Monactin only. The mixture does not contain any other natcins, such as Dinactin, Trinactin, Tetranactin. Nonactin batches released since May 2010 are better than 95% Nonactin by NMR; detailed information is available on request.

InChl Key
RMIXHJPMNBXMBU-QIIXEHPYSA-N
Canonical SMILES
CC1CC2CCC(O2)C(C(=O)OC(CC3CCC(O3)C(C(=O)OC(CC4CCC(O4)C(C(=O)OC(CC5CCC(O5)C(C(=O)O1)C)C)C)C)C)C)C
Isomeric SMILES
C[C@@H]1C[C@H]2CC[C@H](O2)[C@@H](C(=O)O[C@H](C[C@@H]3CC[C@@H](O3)[C@H](C(=O)O[C@@H](C[C@H]4CC[C@H](O4)[C@@H](C(=O)O[C@H](C[C@@H]5CC[C@@H](O5)[C@H](C(=O)O1)C)C)C)C)C)C)C
Solubility ( literature )

soluble in Methanol, Dichloromethane, Ethyl Acetate, DMSO.

Insoluble in water

Storage, handling
Refrigerate upon arrival, at +2°C to +8°C
Hygroscopic substance.
Protect from moisture
Open carefully.
Other vendors may recommend higher temperatures for storage.
Applications

Nonactin has an inhibitory effects on the P170 glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug-resistant cancer cells.

Nonactin, a natural mixture of macrotetrolides, was used in agriculture under the name trade POLYNACTIN. Nonactin has been reported to specifically inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria.

Nonactin is used in urea and ammonium specific electrodes.

Disclaimer
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Antibiotics
Ionophores
Signal to sort
N

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Price
$1.00
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