Nonactin
Molecular Formula
C40H64O12
M.W.
736.93
CAS number
6833-84-7
Source
Streptomyces griseus
Fermentek product Code
NON-002
Brand/grade
For research
Appearance
White to off white powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml DMSO or Dichloromethane
Names and identifiers

 

  • Ammonium Ionophore
  • Werramycin A
  • Polynactin

RTECS: RH1685000

 

EU number
229-911-3
Chemical name
4,13,22,31,37,38,39,40-Octaoxapentacyclo(32.2.1.1(sup 7,10).1(sup 16,19).1(sup 25,28))tetracontane-3,12,21,30-tetrone, 2,5,11,14,20,23,29,32-octamethyl-, (1R-(1R*,2R*,5R*,7R*,10S*,11S*,14S*,16S*,19R*,20R*,23R*,25R*,28S*,29S*,32S*,34S*))-
Description

Nonactin is a member of a family of naturally occurring cyclic ionophores known as the macrotetrolide antibiotics. The other members of this homologous family are monactin, dinactin, trinactin, and tetranactin, which are all neutral ionophoric substances and higher homologs of nonactin. Collectively, this class is known as the nactins. 

Fermentek started manufacturing of , containing also the lower homologs) in 1993. Since 2025 Fermentek has manufactured pure Nonactin. 

The mixture of Nonactin and its homologs is also manufactured and is marketed under the name Nonactin Complex.

InChl Key
RMIXHJPMNBXMBU-QIIXEHPYSA-N
Canonical SMILES
CC1CC2CCC(O2)C(C(=O)OC(CC3CCC(O3)C(C(=O)OC(CC4CCC(O4)C(C(=O)OC(CC5CCC(O5)C(C(=O)O1)C)C)C)C)C)C)C
Isomeric SMILES
C[C@@H]1C[C@H]2CC[C@H](O2)[C@@H](C(=O)O[C@H](C[C@@H]3CC[C@@H](O3)[C@H](C(=O)O[C@@H](C[C@H]4CC[C@H](O4)[C@@H](C(=O)O[C@H](C[C@@H]5CC[C@@H](O5)[C@H](C(=O)O1)C)C)C)C)C)C)C
Solubility ( literature )

soluble in Methanol, Dichloromethane, Ethyl Acetate, DMSO. Insoluble in water

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Applications

Nonactin has an inhibitory effects on the P170 glycoprotein mediated efflux of chemotherapeutic agents in multiple drug resistant cancer cells.

Nonactin was used in agriculture under the name trade Polynactin. Nonactin has been reported to specifically inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria.

Nonactin is used in urea and ammonium specific electrodes.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Shipped in amber-glass vials
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Antibiotics
Ionophores
Signal to sort
M

Quote for

Larger quantities available. Please enquire
Price
$1.00
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