Cancer is most accurately described as a class of diseases characterized by uncontrolled cell growth and division.There are more than a hundred defined types of cancer.

Cancer can occur in nearly every organ or tissue in the body.

Various small molecules are widely used in the research of cancer. Especially in the last decade, cancer research has evolved from a one-size-fits-all approach that emphasized cytotoxic chemotherapy to a more personalized medical strategy that focuses on the discovery and development of targeted drugs.

These drugs are designed, on a molecular level, to exploit particular genetic dependencies, addictions, and vulnerabilities of cancer cells.

Much current cancer research is concentrated in the areas of programmed cell death, tumor invasion and angiogenesis, tumor immunology, oncogenic signaling, gene expression and copy number, epigenetic regulation, toxicity and chemoresistance, metabolic stress and damage to DNA. Fermentek offers more than 30 unique biochemicals currently being used in cancer research.

PX-866

PX-866 (Sonolisib)
Molecular Formula
C29H35NO8
M.W.
525.59
CAS number
502632-66-8
MSDS
Source
Semisynthetic
Fermentek product Code
PX8-001
Brand/grade
For research
Appearance
Orange powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear yellowish solution at 10mg/ml of Methanol or DMSO
Names and identifiers

Synonym:

Sonolisib

Chemical name:

  • (1E,​4S,​4aR,​5R,​6aS,​9aR)-​5-​(acetyloxy)-​1-​[(di-​2-​propen-​1-​ylamino)methylene]-​4,​4a,​5,​6,​6a,​8,​9,​9a-​octahydro-​11-​hydroxy-​4-​(methoxymethyl)-​4a,​6a-​dimethyl-​cyclopenta[5,​6]naphtho[1,​2-​c]pyran-​2,​7,​10(1H)-​trione
  • Sonolisib
EU number
812-171-6
Description

PX-866 is a synthetic derivate of wortmannin.

InChl Key
QIUASFSNWYMDFS-NILGECQDSA-N
Canonical SMILES
CC(=O)OC1CC2(C(CCC2=O)C3=C1C4(C(OC(=O)C(=CN(CC=C)CC=C)C4=C(C3=O)O)COC)C)C
Isomeric SMILES
CC(=O)O[C@@H]1C[C@]2([C@@H](CCC2=O)C3=C1[C@]4([C@H](OC(=O)/C(=C/N(CC=C)CC=C)/C4=C(C3=O)O)COC)C)C
Solubility ( literature )

Methanol , DMSO, Ethyl acetate, Ethanol

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications
  • Potential anti-cancer agent;
  • Phosphatidylinositol 3-kinase inhibitor
Disclaimer
For Research use only
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Available since
Fermentek Product Category
Research field: Cancer
Cancer Related Compounds
Others
Signal to sort
P

Quote for

Price
$1.00
PX-866__Sonolisib_.gif
PX-866__Sonolisib_.gif

Puromycin Aminonucleoside

Puromycin Aminonucleoside
Molecular Formula
C12H18N6O3
M.W.
294.30
CAS number
58-60-6
MSDS
Source
Semisynthetic (from Puromycin)
Fermentek product Code
PAN-001
Brand/grade
For research
Appearance
White to off white powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 50 mg/ml DMSO;
Clear colorless solution at 10 mg/ml water
Names and identifiers

RTECS: AU7337000

EU number
200-387-8
Description

Puromycin Aminonucleoside is a puromycin analog which does not inhibit protein synthesis or induce apoptosis

InChl Key
MKSVFGKWZLUTTO-FZFAUISWSA-N
Canonical SMILES
CN(C)C1=NC=NC2=C1N=CN2C3C(C(C(O3)CO)NC(=O)C(CC4=CC=C(C=C4)OC)N)O.Cl.Cl
Isomeric SMILES
CN(C)C1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)NC(=O)[C@H](CC4=CC=C(C=C4)OC)N)O.Cl.Cl
Solubility ( literature )

Water

Compound Classification
  • Nucleoside antibiotic
  • Protein synthesis inhibitor

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Available since
Title
Deleted CAS Numbers
Value
28315-29-9 ; 54833-68-0 ; 136680-68-7
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Antibiotics
Research field: Cancer
Apoptosis related
DNA replication inhibitors
Signal to sort
P

Quote for

Price
$1.00
Puromycin_aminonucleoside.gif
Puromycin_aminonucleoside.gif

PKC412

PKC412 (Midostaurin)
Molecular Formula
C35H30N4O4
M.W.
570.60
CAS number
120685-11-2
Source
Synthetic
Fermentek product Code
PKC-001
Brand/grade
For research
Appearance
White to off white powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml DMSO; Clear colorless solution at 5mg/ml methanol
Names and identifiers

Synonyms:

  • Midostaurin
  • PKC412
  • Benzoylstaurosporine
  • 4'-N-Benzoylstaurosporine

Commercial names: 

  • Rydapt

RTECS: CV5045180

Chemical name
4'-N-benzoyl staurosporine
Description

PKC412 (Midostaurin) is a cell permeable inhibitor of protein kinases, including protein kinase-C.

InChl Key
BMGQWWVMWDBQGC-UHFFFAOYSA-N
Canonical SMILES
CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)N(C)C(=O)C9=CC=CC=C9)OC
Isomeric SMILES
C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)N(C)C(=O)C9=CC=CC=C9)OC
Solubility ( literature )

Soluble in DMSO, Dichloromethane.
Water solubility : < 0.1 mg/1

Compound Classification
  • indolocarbazole alkaloid
  • PKC inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Protect from moisture! Hygroscopic substance.
Retest time
3 Years
Applications
  • PKC412 is mentioned as a specific treatment for Myeloproliferative Disease (MPD)
  • PKC412 selectively inhibits protein kinase C (PKC)
  • Investigated for use/treatment in adult patients with high-risk acute myeloid leukemia (AML)
Disclaimer
Semi-Synthetic.
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Research field: Cancer
Angiogenesis related
Protein kinase related
Cancer Related Compounds
Research field: Signal Transduction
Others
Signal to sort
P

Quote for

Price
$1.00
PKC412__Midostaurin_.gif
PKC412__Midostaurin_.gif

Penicillic acid

Penicillic acid
Molecular Formula
C8H10O4
M.W.
170.16
CAS number
90-65-3
Source
Penicillium Cyclopium
Fermentek product Code
PEN-001
Brand/grade
For research
Appearance
white to light yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ ml Dichloromethane
Names and identifiers

Synonyms: 

  • 3-Methoxy-5-methyl-4-oxo-2,5-hexadienoic acid

HSDB 3523

RTECS  MM2625000

EU number
202-008-1
Chemical name
3-Methoxy-5-methyl-4-oxo-2,5-hexadienoic acid
Description

Penicillic acid is a polyketide mycotoxin which induces single and double strand DNA breaks. It inhibits GDP-mannose dehydrogenase. It inhibits also muscle aldose dehydrogenase, lactate dhydrogenase and alcohol dehydrogenase.

InChl Key
VOUGEZYPVGAPBB-XQRVVYSFSA-N
Canonical SMILES
CC(=C)C(=O)C(=CC(=O)O)OC
Isomeric SMILES
CC(=C)C(=O)/C(=C/C(=O)O)/OC
Solubility ( literature )

Water, Ethanol, Dichloromethane.

Compound Classification
  • Lactone Mycotoxin
  • Hexanoic Acid
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Fermentek Product Category
Mycotoxins
Other mycotoxins
Enzyme-inhibitors
Research field: Cancer
Anti Bacterial
DNA replication inhibitors
Signal to sort
P

Quote for

Price
$1.00
Penicillic_Acid.gif
Penicillic_Acid.gif

Parthenolide

Parthenolide
Molecular Formula
C15H20O3
M.W.
248.32
CAS number
20554-84-1
MSDS
Source
Tanacetum parthenium
Fermentek product Code
PAR-001
Brand/grade
For research
Appearance
White to off white powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless to faint yellow solution at 50mg/ml Dichloromethane; Clear colorless to faint yellow solution at 50mg/ml DMSO
Names and identifiers

IUPAC name: (1aR,4E,7aS,10aS,10bS)-1a,5-Dimethyl-8-methylene-2,3,6,7,7a,8,10a,10b-octahydrooxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one

RTECS: LY4220000

EU number
692-532-0
Chemical name
Parthenolide
Description

Parthenolide is a sesquiterpene lactone and active principle of feverfew (Chrysanthemum parthenium)

InChl Key
KTEXNACQROZXEV-PVLRGYAZSA-N
Canonical SMILES
CC1=CCCC2(C(O2)C3C(CC1)C(=C)C(=O)O3)C
Isomeric SMILES
C/C/1=C\CC[C@@]2([C@H](O2)[C@@H]3[C@@H](CC1)C(=C)C(=O)O3)C
Solubility ( literature )

DMSO (100 mg/ml), Ethanol (20 mg/ml), Dichloromethane.

Compound Classification
  • sesquiterpene lactone

MAP kinase inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Applications

Parthenolide has anti-inflammatory, antisecretory and spasmolytic activity. It Inhibits the release of various mediators. It inhibits activation of MAP kinase.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Plant-derived
Antibiotics
Research field: Cancer
Protein kinase related
Research field: Signal Transduction
Signal to sort
P

Quote for

Price
$1.00
Parthenolide.gif
Parthenolide.gif

Paclitaxel (Taxol)

Paclitaxel (Taxol)
Molecular Formula
C47H51NO14
M.W.
853.90
CAS number
33069-62-4
Source
Taxus brevifolia ( a plant extract)
Fermentek product Code
PAC-001
Brand/grade
For research
Appearance
White crystalline solid.
Purity by HPLC
≥ 98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 50mg/ml of Methanol.
Names and identifiers

RTECS: DA8340700

EU number
608-826-9
Description

Paclitaxel (taxol) is an antineoplastic agent from a plant extract.

Paclitaxel  (taxol) stabilizes microtubules in their polymerized form thus leading to cell death

InChl Key
RCINICONZNJXQF-MZXODVADSA-N
Canonical SMILES
CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
Isomeric SMILES
CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
Solubility ( literature )

DMSO, Methanol, Ethanol. Unstable in Methanol.

Compound Classification
  • Cyclodecane
  • Antitumor agent.
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

A antineoplastic drug. A tool in Microtubuli research

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Fermentek Product Category
Plant-derived
Research field: Cancer
Angiogenesis related
Research field: Signal Transduction
Signal to sort
P

Quote for

Price
$1.00
Paclitaxel__Taxol_.gif
Paclitaxel__Taxol_.gif

Okadaic Acid

Okadaic Acid
Molecular Formula
C44H68O13
M.W.
805.00
CAS number
78111-17-8
MSDS
Source
Marine dinoflagellates
Fermentek product Code
OKA-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 5mg/ml EtOH;
Clear colorless solution at 40mg/ml DMSO
Names and identifiers

RTECS AA8227800

EU number
616-589-8
Chemical name
Acanthifolicin, 9,10-deepithio-9,10-didehydro-
Description

Inhibitor of protein phosphatase

InChl Key
QNDVLZJODHBUFM-WFXQOWMNSA-N
Canonical SMILES
CC1CCC2(CCCCO2)OC1C(C)CC(C3C(=C)C(C4C(O3)CCC5(O4)CCC(O5)C=CC(C)C6CC(=CC7(O6)C(CCC(O7)CC(C)(C(=O)O)O)O)C)O)O
Isomeric SMILES
C[C@@H]1CC[C@]2(CCCCO2)O[C@@H]1[C@@H](C)C[C@@H]([C@@H]3C(=C)[C@H]([C@H]4[C@H](O3)CC[C@]5(O4)CC[C@@H](O5)/C=C/[C@@H](C)[C@@H]6CC(=C[C@@]7(O6)[C@@H](CC[C@H](O7)C[C@](C)(C(=O)O)O)O)C)O)O
Solubility ( literature )

Reportedly, Okadaic acid is soluble in acetone, methanol, ethanol, chloroform or ethyl acetate.

Compound Classification

Polyether antibiotic

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Retest time
3 Years
Applications

Okadaic Acid is a potent non-TPA type tumor promoter and vasodilator. It induces hyperphosphorylation of the P53 oncoprotein

Ingredient type
Fermentek product
Available since
Title
Additional Transport Information:
Value
De Minimis Quantities exemption, per IATA 2.6.10 - applicable.
Title
Transpoprt information
Value
Pg III
Title
Storage considerations
Value
Some other sources recommend storing under inert gase
Fermentek Product Category
Research field: Cancer
Apoptosis related
Protein kinase related
DNA replication inhibitors
Research field: Signal Transduction
Others
Signal to sort
O

Quote for

Price
$1.00
Okadaic_Acid.gif
Okadaic_Acid.gif

Nivalenol

Nivalenol
Molecular Formula
C15H20O7
M.W.
312.32
CAS number
23282-20-4
Source
Semisynthetic
Fermentek product Code
NIV-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10 mg/ml Methanol or DMSO
Names and identifiers

IUPAC Name
(3β,4α,7α,12ξ)-3,4,7,15-Tetrahydroxy-12,13-epoxytrichothec-9-en-8-one

RTECS#
YD0167000

EU number
621-749-5
Description

Nivalenol is a type - B trichothecene mycotoxin produced by various Fusarium species, such as Fusarium cerealis, Fusarium graminearum, Fusarium nivale. Besides the natural toxin produced directly by molds, Nivalenol may be also formed by higher plants and by mammals, as a product of biodegradation of other, related thrichothecenes.

InChl Key
UKOTXHQERFPCBU-XLYGLCRNSA-N
Canonical SMILES
CC1=CC2C(C(C1=O)O)(C3(C(C(C(C34CO4)O2)O)O)C)CO
Isomeric SMILES
CC1=C[C@@H]2[C@]([C@@H](C1=O)O)([C@]3([C@@H]([C@H]([C@H](C34CO4)O2)O)O)C)CO
Solubility ( literature )

Dichloromethane, DMSO, Methanol. Slightly soluble in water

Compound Classification

Chemical class:
Trichothecene mycotoxin

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
trichocethenes are thermostable compounds and are not destroyed in boiling.
Retest time
3 Years
Applications

Nivalenol (0.01 mg/ml) induces apoptosis in HL60 cells (Ueno et al., 1995). Nivalenol was shown to inhibit protein synthesis in rabbit reticulocytes in vitro. Nivalenol inhibited the synthesis of nucleic acids in vitro.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Available since
Fermentek Product Category
Mycotoxins
Trichocothecenes
Research field: Cancer
Apoptosis related
Signal to sort
N

Quote for

Price
$1.00
Nivalenol.gif
Nivalenol.gif

Nigericin (sodium salt)

Nigericin (sodium salt)
Molecular Formula
C40H67O11∙Na
M.W.
746.93
CAS number
28643-80-3 (sodium salt)
MSDS
Source
Streptomyces hygroscopicus
Fermentek product Code
NIG-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml of Dichloromethane
Names and identifiers

Polyetherin A; Azalomycin M; Helixin C ;

RTECS QT6825000

EU number
608-231-4
Description

Nigericin is a polyether antibiotic which affects ion transport and ATPase activity in mitochondria.

Nigericin is produced by Streptomyces hygroscopicus. Nigericin, an ionophore and antibiotic, is supplied as a sodium salt.

Nigericin is one of the compounds successfully tested as a feed additive, displaying a significant effect on milk production in cattle. In vitro, nigericin has broad biological activity against Gram positive bacteria, fungi, tumor cell lines and some viruses, including HIV.

InChl Key
MOYOTUKECQMGHE-NTQCAYBPSA-M
Canonical SMILES
CC1CCC(OC1C(C)C(=O)[O-])CC2CC(C(C3(O2)C(CC(O3)(C)C4CCC(O4)(C)C5C(CC(O5)C6C(CC(C(O6)(CO)O)C)C)C)C)C)OC.[Na+]
Isomeric SMILES
C[C@H]1CC[C@@H](OC1[C@@H](C)C(=O)[O-])C[C@@H]2C[C@H]([C@H]([C@@]3(O2)[C@@H](C[C@@](O3)(C)C4CC[C@@](O4)(C)C5[C@H](C[C@@H](O5)[C@@H]6[C@H](C[C@H]([C@@](O6)(CO)O)C)C)C)C)C)OC.[Na+]
Solubility ( literature )

DMSO, Ethanol, petrol ether. Not soluble in water

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully – Lyophilized solid under vacuum
Retest time
3 Years
Applications

Disrupts the membrane potential and stimulates ATPase activity in mitochondria.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Shipped in amber-glass vials
Available since
Title
More about
Value
Nigericin f.a.; cas 28380-24-7 rtecs QT6825000, mouse oral ld50=190 mg/kg
Fermentek Product Category
Antibiotics
Research field: Cancer
Ionophores
Signal to sort
N
Nigericin__sodium_salt_.gif
Nigericin__sodium_salt_.gif

Mitomycin C

Mitomycin C
Molecular Formula
C15H18N4O5
M.W.
334.30
CAS number
50-07-7
MSDS
Source
Streptomyces caespitous
Fermentek product Code
MTC-001
Brand/grade
For research
Appearance
Blue-violet solid
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear blue-violet solution at 10mg/ml Methanol
Names and identifiers

Synonyms:

  • mutamycin
  • ametycin, 
  • mitocin-C,

IUPAC name:
{11-Amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl}methyl carbamate

RTECS: CN0700000

 

EU number
200-008-6
Description

Mitomycin C is an anti-tumor antibiotic that binds covalently to DNA.

Mitomycin C has also antibacterial properties.

InChl Key
NWIBSHFKIJFRCO-WUDYKRTCSA-N
Canonical SMILES
CC1=C(C(=O)C2=C(C1=O)N3CC4C(C3(C2COC(=O)N)OC)N4)N
Isomeric SMILES
CC1=C(C(=O)C2=C(C1=O)N3C[C@H]4[C@@H]([C@@]3([C@@H]2COC(=O)N)OC)N4)N
Solubility ( literature )

Soluble is Methanol; Soluble in water.

Compound Classification

Indolequinone antibiotic.

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Other vendors may recommend storage at 4ºC
Retest time
3 Years
Applications

Mitomycin C is also available as a a 4% mixture in NaCL. See "Mitomycin C+NaCL" Sample CoA

Disclaimer
For Research use only
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Fermentek Product Category
Antibiotics
Research field: Cancer
Apoptosis related
Anti Tumor agents
Signal to sort
M

Quote for

Price
$1.00
Mitomycin_C.gif
Mitomycin_C.gif
Subscribe to Research field: Cancer