Purity by HPLC:
≥98% ; refer to CoA for more data
Purity By TLC:
Single spot on TLC plates, by multiple methods.
225°C to 235°C
Clear colorless solution at 10mg/ml DMSO; Clear colorless solution at 5mg/ml methanol
Names and identifiers:
PKC412 (Midostaurin) is a cell permeable inhibitor of protein kinases, including protein kinase-C.
Solubility ( literature ):
Soluble in DMSO, Dichloromethane.
Water solubility : < 0.1 mg/1
- indolocarbazole alkaloid
- PKC inhibitor
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Protect from moisture! Hygroscopic substance.
- PKC412 is mentioned as a specific treatment for Myeloproliferative Disease (MPD)
- PKC412 selectively inhibits protein kinase C (PKC)
- Investigated for use/treatment in adult patients with high-risk acute myeloid leukemia (AML)