PKC412 (Midostaurin)
Molecular Formula
C35H30N4O4
M.W.
570.60
CAS number
120685-11-2
Details
Source
Synthetic
Fermentek product Code
PKC-001
Brand/grade
For research
Specifications
Appearance
White to off-white powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
225°C-235°C
Solubility test
Clear colorless solution at 10mg/ml DMSO; Clear colorless solution at 5mg/ml methanol
Chemical identification
Names and identifiers
Synonyms:
- Midostaurin
- PKC412
- Benzoylstaurosporine
- 4'-N-Benzoylstaurosporine
Commercial names:
- Rydapt
RTECS: CV5045180
Chemical name
4'-N-benzoyl staurosporine
Description
PKC412 (Midostaurin) is a cell permeable inhibitor of protein kinases, including protein kinase-C.
InChl Key
BMGQWWVMWDBQGC-UHFFFAOYSA-N
Canonical SMILES
CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)N(C)C(=O)C9=CC=CC=C9)OC
Further Information
Solubility ( literature )
Soluble in DMSO, Dichloromethane.
Water solubility : < 0.1 mg/1
Compound Classification
- indolocarbazole alkaloid
- PKC inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Protect from moisture! Hygroscopic substance.
Applications
- PKC412 is mentioned as a specific treatment for Myeloproliferative Disease (MPD)
- PKC412 selectively inhibits protein kinase C (PKC)
- Investigated for use/treatment in adult patients with high-risk acute myeloid leukemia (AML)
Disclaimer
Semi-Synthetic.
Composition
Ingredient type
Fermentek product
Special Info
Available since
Other Fields
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Signal to sort
P
