Staurosporine
Molecular Formula
C28H26N4O3
M.W.
466.53
CAS number
62996-74-1
MSDS
Source
Streptomyces staurosporeus
Fermentek product Code
STA-001
Appearance
Off-white to light yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
255°C-275°C
Solubility test
Clear colorless solution at 5mg/ml Ethyl Acetate,
Clear yellow solution at 25mg/ml DMSO
Names and identifiers

Synonyms:  Antibiotic AM 2282; 

RTECS: KD5084000   ;  attention: This RTECS record belongs to the Hydrochloride salt of Staurosporine, rather than the free base form.

EU number
613-127-7
Chemical name
Staurosporine
Description

Staurosporine is a cell permeable inhibitor of protein kinases, including protein kinase-C.   Inhibitor of nuclear factor kappa B kinase beta subunit.

InChl Key
HKSZLNNOFSGOKW-FYTWVXJKSA-N
Canonical SMILES
CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC
Isomeric SMILES
C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC
Solubility ( literature )

DMSO, Methanol, Ethanol, Ethyl Acetate. Water insoluble

Compound Classification
  • Chemical classification: Indolocarbazole alkaloid
  • Bio-activity: PKC inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Applications
  • Pharmacological tool to study signal transduction pathways, tyrosine phosphorylation and to induce apoptosis.
  • May participate in antigen-induced T-cell activation;
  • Affects Proto-oncogene serine/threonine-protein kinase Pim-1, T-cell-specific kinase, Tyrosine-protein kinase SYK, MAP kinase-activated protein kinase 2
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Shipped in PP / PE bottle.
Available since
Title
Transport information
Value
Not hazardous for transport
Title
Deleted CAS numbers
Value
109189-95-9
Title
Safety comments
Value
Others say it is cancerogen, explosive. We think, because theirs contains ligroyin.
Title
identity comments
Value
HCl salt thereof: C28-H26-N4-O3.Cl-H ; RTECS KD5084000;
Signal to sort
S