Synonyms: Antibiotic AM 2282;
IUPAC name: (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[22.214.171.124²,⁶.0⁷,²⁸.0⁸,¹³.0¹⁵,¹⁹.0²⁰,²⁷.0²¹,²⁶]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one
Staurosporine is a cell permeable inhibitor of protein kinases, including protein kinase-C. Inhibitor of nuclear factor kappa B kinase beta subunit.
DMSO, Methanol, Ethanol, Ethyl Acetate. Water insoluble
Chemical classification: Indolocarbazole alkaloid
Bio-activity: PKC inhibitor
Pharmacological tool to study signal transduction pathways, tyrosine phosphorylation and to induce apoptosis.
May participate in antigen-induced T-cell activation;
Affects Proto-oncogene serine/threonine-protein kinase Pim-1, T-cell-specific kinase, Tyrosine-protein kinase SYK, MAP kinase-activated protein kinase 2