Specifications
Chemical identification
IUPAC name: (1aR,4E,7aS,10aS,10bS)-1a,5-Dimethyl-8-methylene-2,3,6,7,7a,8,10a,10b-octahydrooxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one
RTECS: LY4220000
Parthenolide is a sesquiterpene lactone and active principle of feverfew (Chrysanthemum parthenium)
Further Information
DMSO (100 mg/ml), Ethanol (20 mg/ml), Dichloromethane. More.Standard Draize testAdministration onto the skinHuman0.1%/2DCODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975- Volume(issue)/page/year: 57,218,2007TDLo - Lowest published toxic doseOralRodent - mouse50 mg/kgBiochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammationFCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 41,1381,2003No LD50 at all TDLo - Lowest published toxic doseIntraperitonealRodent - mouse100 mg/kg/20D (intermittent)Cardiac - changes in heart weight Kidney/Ureter/Bladder - changes in kidney weight Nutritional and Gross Metabolic - other changesPYTOEY Phytomedicine. (Gustav Fischer Verlag, Postfach 720143, D-70577 Stuttgart, Germany) V.1- 1994- Volume(issue)/page/year: 20,992,2013TDLo - Lowest published toxic doseIntraperitonealRodent - mouse500 mg/kg/20D (intermittent)Nutritional and Gross Metabolic - other changes Tumorigenic - protects against induction of experimental tumors Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effectsPYTOEY Phytomedicine. (Gustav Fischer Verlag, Postfach 720143, D-70577 Stuttgart, Germany) V.1- 1994- Volume(issue)/page/year: 20,992,2013 Synonyms/Trade Names* 4,5-alpha-Epoxy-6-beta-hydroxygermacra-1(10),11(13)-dien-12-oic acid gamma-lactone* Parthenolide RTECS NumberLY4220000 Chemical NameGermacra-1(10),11(13)-dien-12-oic acid, 4,5-alpha-epoxy-6-beta-hydroxy-, gamma-lactone CAS Registry Number20554-84-1 Last Updated202012 Data Items Cited47 Molecular FormulaC15-H20-O3 Molecular Weight248.35 Compound DescriptorTumorigenMutagenHumanNatural ProductPrimary Irritant
- sesquiterpene lactone
MAP kinase inhibitorSafety comments---------------FCTOD7 Food and Chemical Toxicology. 41,1381,2003TDLo - Lowest published toxic dose, Oral mouse 50 mg/kg; Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation----------------------PYTOEY Phytomedicine V.1- 1994- Volume(issue)/page/year: 20,992,2013TDLo - Lowest published toxic dose Intraperitoneal mouse 100 mg/kg/20D (intermittent) (equal to 5 mg/kg IP each day over 20 Days_ Cardiac - changes in heart weight Kidney/Ureter/Bladder - changes in kidney weight Nutritional and Gross Metabolic - other changesTDLo - Lowest published toxic dose Intraperitoneal mouse 500 mg/kg/20D (intermittent) (equal to 25 mg/kg IP each day over 20 Days_ Nutritional and Gross Metabolic - other changes Tumorigenic - protects against induction of experimental tumors Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects-------------------------- TOXICOLOGY REVIEWMUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 728,139,2011TOXICOLOGY REVIEWPYTOEY Phytomedicine. (Gustav Fischer Verlag, Postfach 720143, D-70577 Stuttgart, Germany) V.1- 1994- Volume(issue)/page/year: 21,1,2013TOXICOLOGY REVIEWJOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 176,177,2015
Parthenolide has anti-inflammatory, antisecretory and spasmolytic activity. It Inhibits the release of various mediators. It inhibits activation of MAP kinase.
