Antibiotics are antimicrobial compounds used in the treatment and prevention of bacterial infection. They can either kill or they can inhibit the growth of bacteria. Several antibiotics are also effective against fungi and protozoans. Some are toxic to humans and animals, even when given in therapeutic dosages. Antibacterial antibiotics are commonly classified based on their mechanism of action, chemical structure, or spectrum of activity. Most antibiotics target bacterial metabolic functions or growth processes. Those antibiotics that interfere with the function of essential bacterial enzymes, or that target the bacterial cell wall or the cell membrane, are usually bactericidal. Those that target protein synthesis are usually bacteriostatic. Further categorizations can be made based on target specificity. Use of antibiotics is essential in retaining the purity of particular selection factors in populations of cells. In recent years antibiotics have been found to be valuable in a wide range of life science disciplines. Fermentek has had particular success in manufacturing antibiotics using fermentation processes.

Rapamycin

Rapamycin
Molecular Formula
C51H79NO13
M.W.
914.17
CAS number
53123-88-9
MSDS
Source
Streptomyces hygroscopicus
Fermentek product Code
RAP-001
Appearance
White to slight yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless to slight yellow solution at 200mg/ml DMSO
Names and identifiers

Synonyms: RAPA, Rapamune, Sirolimus, RPM, Antibiotic AY 22989

RTECS: VE6250000

EU number
610-965-5
Description

Rapamycin (Sirolimus) is a macrolide compound that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus (Rapamycin) is a potent immunosuppressant. Sirolimus (Rapamycin) possesses both antifungal and antineoplastic properties.

InChl Key
QFJCIRLUMZQUOT-HPLJOQBZSA-N
Canonical SMILES
CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)O)C)C)O)OC)C)C)C)OC
Isomeric SMILES
C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)O)C)/C)O)OC)C)C)/C)OC
Solubility ( literature )

Methanol, DMSO

Compound Classification

macrolide immunosuppressor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Retest time
3 Years
Applications

Research applications: Rapamycin Sirolimus inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways. Rapamycin Sirolimus inhibits T-lymphocyte activation / proliferation occuring in response to antigenic and cytokine (Interleukin IL-2, IL-4, and IL-15) stimulation by a mechanism that is distinct from that of other immunosuppressing agents. Sirolimus also inhibits antibody production.

Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Antibiotics
Anti Fungal
Anti Bacterial
Immunomodulators
Signal to sort
R

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Rapamycin.gif
Rapamycin.gif

Radicicol

Radicicol
Molecular Formula
C18H17O6Cl
M.W.
364.78
CAS number
12772-57-5
MSDS
Source
Humicola grisea
Fermentek product Code
RAD-001
Brand/grade
For research
Appearance
White to light yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 20mg/ml DMSO
Names and identifiers

Synonyms:

  • Monorden
  • (2Z,4E)-8-chloro-9,11-dihydroxy-14-methyl-1a,14,15,15a-tetrahydro-6H-oxireno[e][2]benzoxacyclotetradecine-6,12(7H)-dione

RTECS: RR1105000

EU number
642-889-3
Description

Radicicol is a macrolactone antibiotic. Radicicol is a tyrosine kinase inhibitor. It displays anti-angiogenic activity.

InChl Key
YZWZEOGROVVHK-GTMNPGAYSA-N
Canonical SMILES
CC1CC2C(O2)C=CC=CC(=O)CC3=C(C(=CC(=C3Cl)O)O)C(=O)O1
Isomeric SMILES
C[C@@H]1C[C@@H]2[C@H](O2)/C=C\C=C\C(=O)CC3=C(C(=CC(=C3Cl)O)O)C(=O)O1
Solubility ( literature )

Methanol, Ethanol, DMSO.

Compound Classification
  • macrolactone
  • tyrosine kinase inhibitor
  • angiogeniesis inhibitor
  • HSP90 inhibitor
  • Anti fungal
  •  
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Avoid exposing to strong direct light.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
HSP90 inhibitors
Angiogenesis related
Protein kinase related
Anti Fungal
Anti Protozoal
Signal to sort
R

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Radicicol.gif
Radicicol.gif

Puromycin dihydrochloride

Puromycin dihydrochloride
Molecular Formula
C22H29N7O5·2HCl
M.W.
544.43
CAS number
58-58-2
MSDS
Source
Streptomyces alboniger
Fermentek product Code
PUR-001
Brand/grade
For research
Appearance
White to off white to slightly pink powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless to slightly yellow to brown solution at 50mg/ml of water
Names and identifiers

Synonyms: 

  • Stylomycin
  • Achromycin

IUAPC name: 3'-deoxy-N,N-dimethyl-3'-[(O-methyl-L-tyrosyl)amino]adenosine dihydrochloride

RTECS AU7355000

EU number
200-388-3
Chemical name
Adenosine, 3'-​[[(2S)​-​2-​amino-​3-​(4-​methoxyphenyl)​-​1-​oxopropyl]​amino]​-​3'-​deoxy-​N,​N-​dimethyl-​, hydrochloride (1:2)
Description

Puromycin is a protein synthesis inhibitor. It causes premature chain termination.

InChl Key
RYSMHWILUNYBFW-UHFFFAOYSA-N
Canonical SMILES
CN(C)C1=NC=NC2=C1N=CN2C3C(C(C(O3)CO)N)O
Isomeric SMILES
CN(C)C1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)NC(=O)[C@H](CC4=CC=C(C=C4)OC)N)O.Cl.Cl
Compound Classification
  • Nucleoside antibiotic.
  • Protein synthesis inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Applications

Puromycin is an antibiotic used for selecting mammalian cell lines, which have been transformed by vectors that express puromycin-N-acetyl-transferase. Puromycin is also a Antineoplastic agent. Puromycin possesses antoprotozoal activities (against Trypanozoma)

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to SDS for further safety and handling instructions
Puromycin is available also in "Animal Free version", please inquire.
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Title
RTECS verified toxicity LD50 oral mouse
Value
LD50 720 mg/ml
Fermentek Product Category
Antibiotics
Anti Bacterial
Apoptosis related
Cancer Related Compounds
Signal to sort
P

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Puromycin_dihydrochloride.gif
Puromycin_dihydrochloride.gif

Puromycin Aminonucleoside

Puromycin Aminonucleoside
Molecular Formula
C12H18N6O3
M.W.
294.31
CAS number
58-60-6
MSDS
Source
Semisynthetic
Fermentek product Code
PAN-001
Brand/grade
For research
Appearance
White to off white powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 50mg/ml water, Clear colorless solution at 50mg/ml DMSO
Names and identifiers

RTECS: AU7337000

EU number
200-387-8
Description

Puromycin Aminonucleoside is a puromycin analog which does not inhibit protein synthesis or induce apoptosis

InChl Key
MKSVFGKWZLUTTO-FZFAUISWSA-N
Canonical SMILES
CN(C)C1=NC=NC2=C1N=CN2C3C(C(C(O3)CO)NC(=O)C(CC4=CC=C(C=C4)OC)N)O.Cl.Cl
Isomeric SMILES
CN(C)C1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)NC(=O)[C@H](CC4=CC=C(C=C4)OC)N)O.Cl.Cl
Solubility ( literature )

Water

Compound Classification
  • Nucleoside antibiotic
  • Protein synthesis inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Available since
Title
Deleted CAS Numbers
Value
28315-29-9 ; 54833-68-0 ; 136680-68-7
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Antibiotics
Research field: Cancer
Apoptosis related
DNA replication inhibitors
Signal to sort
P

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$1.00
Puromycin_aminonucleoside.gif
Puromycin_aminonucleoside.gif

Parthenolide

Parthenolide
Molecular Formula
C15H20O3
M.W.
248.32
CAS number
20554-84-1
MSDS
Source
Tanacetum parthenium
Fermentek product Code
PAR-001
Brand/grade
For research
Appearance
White to off white powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless to faint yellow solution at 50mg/ml Dichloromethane; Clear colorless to faint yellow solution at 50mg/ml DMSO
Names and identifiers

IUPAC name: (1aR,4E,7aS,10aS,10bS)-1a,5-Dimethyl-8-methylene-2,3,6,7,7a,8,10a,10b-octahydrooxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one

RTECS: LY4220000

EU number
692-532-0
Chemical name
Parthenolide
Description

Parthenolide is a sesquiterpene lactone and active principle of feverfew (Chrysanthemum parthenium)

InChl Key
KTEXNACQROZXEV-PVLRGYAZSA-N
Canonical SMILES
CC1=CCCC2(C(O2)C3C(CC1)C(=C)C(=O)O3)C
Isomeric SMILES
C/C/1=C\CC[C@@]2([C@H](O2)[C@@H]3[C@@H](CC1)C(=C)C(=O)O3)C
Solubility ( literature )

DMSO (100 mg/ml), Ethanol (20 mg/ml), Dichloromethane.

Compound Classification
  • sesquiterpene lactone

MAP kinase inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Applications

Parthenolide has anti-inflammatory, antisecretory and spasmolytic activity. It Inhibits the release of various mediators. It inhibits activation of MAP kinase.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Plant-derived
Antibiotics
Research field: Cancer
Protein kinase related
Research field: Signal Transduction
Signal to sort
P

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Parthenolide.gif
Parthenolide.gif

Nonactin complex

Nonactin complex (mixture of Nonactin, Monactin, Dinactin and Trinactin)
Molecular Formula
C40H64O12
M.W.
736.93
CAS number
6833-84-7 (for Nonactin)
MSDS
Source
Streptomyces griseus
Fermentek product Code
NON-001
Brand/grade
For research
Appearance
White to off white powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml DMSO or Dichloromethane
Names and identifiers

 

  • Ammonium Ionophore
  • Werramycin A
  • Polynactin

RTECS: RH1685000

EU number
229-911-3
Description

Nonactin (Complex) from Streptomyces Griseus: is a mixture of sum homolog macrotetrolide antibiotics: Nonactin, Monactin or any other homologs such as Dinactin, Trinactin, Tetranactin. It is being manucatured in Fermentek since 2004.

Since 2025, Fermentek manufactures also pure Nonactin and Monactin

 

InChl Key
RMIXHJPMNBXMBU-QIIXEHPYSA-N
Canonical SMILES
CC1CC2CCC(O2)C(C(=O)OC(CC3CCC(O3)C(C(=O)OC(CC4CCC(O4)C(C(=O)OC(CC5CCC(O5)C(C(=O)O1)C)C)C)C)C)C)C
Isomeric SMILES
C[C@@H]1C[C@H]2CC[C@H](O2)[C@@H](C(=O)O[C@H](C[C@@H]3CC[C@@H](O3)[C@H](C(=O)O[C@@H](C[C@H]4CC[C@H](O4)[C@@H](C(=O)O[C@H](C[C@@H]5CC[C@@H](O5)[C@H](C(=O)O1)C)C)C)C)C)C)C
Solubility ( literature )

soluble in Methanol, Dichloromethane, Ethyl Acetate, DMSO.

Insoluble in water

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully
Applications

Nonactin has an inhibitory effects on the P170 glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug-resistant cancer cells.

Nonactin, a natural mixture of macrotetrolides, was used in agriculture under the name trade Polynactin. Nonactin has been reported to specifically inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria.

Nonactin is used in urea and ammonium specific electrodes.

Disclaimer
Not for Human or Drug use
Not extracted from humans or animals
Refer to SDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Antibiotics
Ionophores
Signal to sort
N

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Nonactin.gif
Nonactin.gif

Nigericin (sodium salt)

Nigericin (sodium salt)
Molecular Formula
C40H67O11∙Na
M.W.
746.93
CAS number
28643-80-3 (sodium salt)
MSDS
Source
Streptomyces hygroscopicus
Fermentek product Code
NIG-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml of Dichloromethane
Names and identifiers

Polyetherin A; Azalomycin M; Helixin C ;

RTECS QT6825000

EU number
608-231-4
Description

Nigericin is a polyether antibiotic which affects ion transport and ATPase activity in mitochondria.

Nigericin is produced by Streptomyces hygroscopicus. Nigericin, an ionophore and antibiotic, is supplied as a sodium salt.

Nigericin is one of the compounds successfully tested as a feed additive, displaying a significant effect on milk production in cattle. In vitro, nigericin has broad biological activity against Gram positive bacteria, fungi, tumor cell lines and some viruses, including HIV.

InChl Key
MOYOTUKECQMGHE-NTQCAYBPSA-M
Canonical SMILES
CC1CCC(OC1C(C)C(=O)[O-])CC2CC(C(C3(O2)C(CC(O3)(C)C4CCC(O4)(C)C5C(CC(O5)C6C(CC(C(O6)(CO)O)C)C)C)C)C)OC.[Na+]
Isomeric SMILES
C[C@H]1CC[C@@H](OC1[C@@H](C)C(=O)[O-])C[C@@H]2C[C@H]([C@H]([C@@]3(O2)[C@@H](C[C@@](O3)(C)C4CC[C@@](O4)(C)C5[C@H](C[C@@H](O5)[C@@H]6[C@H](C[C@H]([C@@](O6)(CO)O)C)C)C)C)C)OC.[Na+]
Solubility ( literature )

DMSO, Ethanol, petrol ether. Not soluble in water

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully – Lyophilized solid under vacuum
Retest time
3 Years
Applications

Disrupts the membrane potential and stimulates ATPase activity in mitochondria.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Shipped in amber-glass vials
Available since
Title
More about
Value
Nigericin f.a.; cas 28380-24-7 rtecs QT6825000, mouse oral ld50=190 mg/kg
Fermentek Product Category
Antibiotics
Research field: Cancer
Ionophores
Signal to sort
N

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Nigericin__sodium_salt_.gif
Nigericin__sodium_salt_.gif

Myriocin

Myriocin
Molecular Formula
C21H39NO6
M.W.
401.54
CAS number
35891-70-4
MSDS
Source
Mycelia sterilia (fungus)
Fermentek product Code
MYR-001
Brand/grade
For research
Appearance
White to off white powder
Purity by HPLC
≥95% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 2mg/ml of Methanol (slight heating),
Clear colorless solution at 5mg/ml of DMSO (slight heating)
Names and identifiers
  • Myriocin
  • Thermozymocidin
  • ISP-I
  • (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid
EU number
636-862-5
Description

Fungal antibiotic, atypic amino acid, immunomodulator, serine palmitoyltransferase inhibitor, apoptosis inducer.

InChl Key
ZZIKIHCNFWXKDY-GNTQXERDSA-N
Canonical SMILES
CCCCCCC(=O)CCCCCCC=CCC(C(C(CO)(C(=O)O)N)O)O
Isomeric SMILES
CCCCCCC(=O)CCCCCC/C=C/C[C@H]([C@@H]([C@@](CO)(C(=O)O)N)O)O
Solubility ( literature )

Myriocin is slightly soluble in DMSO, alcohols.Myriocin is insoluble in water and in most organic solvents.

Compound Classification
  • amino-acid antibiotic
  • immunosupressor
  • serine palmitoyltransferase inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Applications

Myriocin, a potent inhibitor of serine palmitoyltransferase,a (the 1st step in sphingosine biosynthesis), is used in biochemical research as a tool for depleting cells of sphingolipids. Myriocin is a potent immunosuppressor, reportedly 10 to 100 times stronger than cyclosporin.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Transport safety: class 6.1 PG III
Available since
Title
Toxicity oral mouse LD50
Value
300 miligram/kg
Fermentek Product Category
Mycotoxins
Antibiotics
Enzyme-inhibitors
Immunomodulators
Research field: Signal Transduction
Signal to sort
M

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Myriocin.gif
Myriocin.gif

Mycophenolic acid

Mycophenolic acid
Molecular Formula
C17H20O6
M.W.
320.34
CAS number
24280-93-1
MSDS
Source
Penicillium brevicompactum
Fermentek product Code
MPA-001
Brand/grade
For research
Appearance
White to off white powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 50mg/ml DMSO
EU number
246-119-3
Description

fatty acid antibiotic

InChl Key
HPNSFSBZBAHARI-RUDMXATFSA-N
Canonical SMILES
CC1=C(C(=C(C2=C1COC2=O)O)CC=C(C)CCC(=O)O)OC
Isomeric SMILES
CC1=C(C(=C(C2=C1COC2=O)O)C/C=C(\C)/CCC(=O)O)OC
Solubility ( literature )

DMSO, Ethanol, Methanol, Dichloromethane. Insoluble in water

Compound Classification

Immunosupressor

Purine nucleotide synthesis inhibitor

Ingredient type
Fermentek product
Title
toxicity oral mouse LD50
Value
1 gr/kg
Title
toxicity oral rat LD50
Value
352 mg/kg
Fermentek Product Category
Antibiotics
Immunomodulators
Others
Signal to sort
M

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Mycophenolic_acid.gif
Mycophenolic_acid.gif

Mycophenolate Mofetil

Mycophenolate Mofetil
Molecular Formula
C23H31NO7
M.W.
433.49
CAS number
128794-94-5
MSDS
Source
synthetic
Fermentek product Code
MYM-001
Brand/grade
For research
Appearance
White to off white powder
Purity by HPLC
≥95% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 50mg/ml DMSO
Names and identifiers

2-Morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate systematic name: 4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-, 2-(4-morpholinyl)ethyl ester, (E)-

RTECS No : MP7746700

EU number
627-027-6
Description

Morpholinoethyl ester of Mycophenolic acid

InChl Key
RTGDFNSFWBGLEC-SYZQJQIISA-N
Canonical SMILES
CC1=C(C(=C(C2=C1COC2=O)O)CC=C(C)CCC(=O)OCCN3CCOCC3)
Solubility ( literature )

Acetone: freely soluble.Methanol: solubleEthanol: Sparingly solubleNeutral water: about 40 µg/mLWater acidified to pH 4: about 4 mg/ml

Compound Classification

Immunomodulator, Immunosuppressor

Storage, handling
-18°C
Retest time
3 Years
Ingredient type
Fermentek product
Available since
Title
Deleted CAS Numbers
Value
115007-34-6; 140401-05-4
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Antibiotics
Immunomodulators
Others
Signal to sort
M

Quote for

Larger quantities available. Please enquire
Price
$1.00
Mycophenolate_Mofetil.gif
Mycophenolate_Mofetil.gif
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