Concanamycin A (Folimycin)

Concanamycin A (Folimycin)
Molecular Formula
C46H75NO14
M.W.
866.09
CAS number
80890-47-7
Source
Streptomyces sp.
Fermentek product Code
CON-001
Brand/grade
For research
Appearance
White crystals
Purity by HPLC
≥97% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml of Methanol
Names and identifiers

Synonyms:

  • Concamycin A
  • Folimycin
  • Concanamycin

Comment: Many other suppliers, as well as PUBCHEM, CHEMSPIDER and publications, consider Folimycin and Concanamycin A to be synonyms, while SCIFINDER considers these compounds to be different.

IUPAC: 

3-O-(4-O-Carbamoyl-2,6-dideoxy-β-D-arabino-hexopyranosyl)-2,4-dideoxy-1-C-{4-[(4E,6E,14E,16Z)-11-ethyl-10,12-dihydroxy-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6,14,16-tetraen- 2-yl]-3-hydroxy-2-pentanyl}-4-methyl-5-[(1E)-1-propen-1-yl]-β-D-threo-pentopyranose

RTECS# CB9732000

 

EU number
620-709-4
Chemical name
Concanamycin A
Description

Macrolide type antibiotic, ATPase inhibitor, having antiproliferative, antifungal and antimalarial effects.

InChl Key
DJZCTUVALDDONK-HQMSUKCRSA-N
Canonical SMILES
CCC1C(C(CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C=CC)C)OC3CC(C(C(O3)C)OC(=O)N)O)O)O)OC)C)C)O
Isomeric SMILES
CC[C@H]1[C@H]([C@@H](C/C(=C/C=C/[C@@H]([C@H](OC(=O)/C(=C/C(=C/[C@H]([C@H]1O)C)/C)/OC)[C@@H](C)[C@H]([C@H](C)[C@]2(C[C@H]([C@@H]([C@H](O2)/C=C/C)C)O[C@H]3C[C@H]([C@@H]([C@H](O3)C)OC(=O)N)O)O)O)OC)/C)C)O
Solubility ( literature )

Concanamycin A is reported to be soluble in chloroform, methanol, ethanol, acetone, ethyl acetate, and DMSO.

Concanamycin A is not soluble in water.

 

 

 

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Protect from light !
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Reportedly, OK to freeze; Frozen stock solutions in DMSO are stable 1 year
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Warnings

NotGMO

Product natural

Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg II
Title
CN code
Value
--
Title
Depreciated CAS Registry Numbers
Value
66771-59-3
Signal to sort
C

Triacsin C

Triacsin C
Molecular Formula
C11H17N3O
M.W.
207.27
CAS number
76896-80-5
MSDS
Source
Streptomyces aureofaciens
Fermentek product Code
TRC-001
Brand/grade
For research
Appearance
Off-white to Dark yellow powder
Purity by HPLC
≥90% ; refer to CoA for more data
Purity By TLC
≥95% ; refer to CoA for more data
Solubility test
Clear yellowish to yellow solution at 5mg/ml of Methanol or DMSO
Names and identifiers

Synonyms

  • 2E, 4E, 7E-Undecatriene-1-triazene
  • 1-hydroxy-3-(2',4',7'-undecatrienylidine)triazene

 

EU number
616-408-2
Chemical name
2,4,7-Undecatrienal, nitrosohydrazone, (2E,4E,7E)-
Description

Triacsin C, an analog of polyunsaturated fatty acid. A potent vasodilator.

InChl Key
NKTGCVUIESDXPU-YLEPRARLSA-N
Canonical SMILES
CCCC=CCC=CC=CC=NNN=O
Isomeric SMILES
CCC/C=C/C/C=C/C=C/C=N/NN=O
Solubility ( literature )

Soluble to 25 mM in DMSO (lit)

Compound Classification

Chemical classification:

  • Triazene class compound
  • Polyunsaturated fatty acid analog.

Classification by bioactivities:

  • Arachidonoyl-CoA synthetase inhibitor
  • Inhibits Synthesis of triacylglycerol and phospholipid
  • Apoptosis inhibitor
  • Vasodilator
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Protect from light !
Avoid exposing to strong direct light.
Store under argon.
Other vendors may recommend higher temperatures for storage.
Attention: this compound may deteriorate quickly if stored improperly
Retest time
1Y
Applications

Selectively inhibits arachidonoyl-CoA synthetase in intact cells. Inhibits the nonspecific acyl-CoA synthetase in cell sonicates. Inhibits neutrophil functions. Inhibits lipid synthesis and cell proliferation in Raji lymphoma cells. Induces apoptosis in cancer cell lines and inhibits human lung cancer cell xenograft tumor growth in mice.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Inhibitor of:
Value
Selective inhibitor of acyl-CoA synthetase
Title
Transport information
Value
Not hazardous for transport
Title
Specifications updated 24-October 2017
Value
Purity ≥90% by HPLC
Signal to sort
T

Forskolin

Forskolin
Molecular Formula
C22H34O7
M.W.
410.50
CAS number
66575-29-9
MSDS
Source
Coleus forskohlii (plant extract)
Fermentek product Code
FOR-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
220°C-230°C
Solubility test
Clear colorless solution at 10mg/ml EtOAc
Names and identifiers

Synonyms :

Boforsin; Colforsin; Coleonol

RTECS QL6150000

EU number
266-410-9
Description

Forskolin is a labdane diterpene that is produced by Coleus forskohlii

InChl Key
OHCQJHSOBUTRHG-KGGHGJDLSA-N
Canonical SMILES
CC(=O)OC1C(C2C(CCC(C2(C3(C1(OC(CC3=O)(C)C=C)C)O)C)O)(C)C)O
Isomeric SMILES
CC(=O)O[C@H]1[C@H]([C@@H]2[C@]([C@H](CCC2(C)C)O)([C@@]3([C@@]1(O[C@@](CC3=O)(C)C=C)C)O)C)O
Solubility ( literature )

Forskolin is soluble in DMSO, Methanol, Ethanol, Dichloromethane, Forskolin may be dissolved in 2% ethanol in water, by dissolving it first in Ethanol and subsequently diluting this solution with water.

Compound Classification
  • diterpene antibiotic
  • vasodilator
Storage, handling
Room temperature or below. Light protection is recommended by other sources.
Expiration time
3Y
Applications
  • Bronchodilator agent,  Agents that cause an increase in the expansion of a bronchus or bronchial tubes.
  • Cardiotonic agent: Agents that have a strengthening effect on the heart or that can increase cardiac output. 
  • Vasodilator agent: Agent   causing dilation of the blood vessels.
  • Forskolin activates Adenylate Cyclase, thus increasing the cyclic AMP intra-cellular concentration. Forskolin is commonly used to raise levels of cyclic AMP (cAMP) in the study and research of cell physiology. Forskolin has been mentioned as a possible weight loss aid, and as a mean to treat Glaucoma, as it may reduce the intraocular pressure. See also United States Patent Application 20100168014
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Fermentek Product Category
Signal to sort
F