Antibiotics are antimicrobial compounds used in the treatment and prevention of bacterial infection. They can either kill or they can inhibit the growth of bacteria. Several antibiotics are also effective against fungi and protozoans. Some are toxic to humans and animals, even when given in therapeutic dosages. Antibacterial antibiotics are commonly classified based on their mechanism of action, chemical structure, or spectrum of activity. Most antibiotics target bacterial metabolic functions or growth processes. Those antibiotics that interfere with the function of essential bacterial enzymes, or that target the bacterial cell wall or the cell membrane, are usually bactericidal. Those that target protein synthesis are usually bacteriostatic. Further categorizations can be made based on target specificity. Use of antibiotics is essential in retaining the purity of particular selection factors in populations of cells. In recent years antibiotics have been found to be valuable in a wide range of life science disciplines. Fermentek has had particular success in manufacturing antibiotics using fermentation processes.

A23187, 4-Bromo

A23187, 4-Bromo
Molecular Formula
C29H36BrN3O6
M.W.
602.52
CAS number
76455-48-6
MSDS
Source
Semisynthetic
Fermentek product Code
A4B-001
Brand/grade
For research
Appearance
Slight yellow to yellow crystals
Purity by HPLC
≥95% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless to yellow solution at 10mg/ml of Dichloromethane
Names and identifiers

Synonyms:

4-Bromo-A23187,

4-Bromocalcimycin,

Systematic Name:

4-Benzoxazolecarboxylic acid, 6-bromo-5-(methylamino)-2-(((2S,3S,6S,8S,9R,11R)-3,9,11-trimethyl-8-((1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl)-1,7-dioxaspiro(5.5)undec-2-yl)methyl)-

RTECS:  n.a.

 

EU number
634-762-6
Chemical name
4-Bromo-A-23187
Description

Brominated Analog of A23187 (Calcimycin). A23187 is an ionophore antibiotic that forms dimeric complexes with divalent cations such an Mn2+ and Ca2+.

InChl Key
LDXQFZZGVTWFCF-FHYGWRBKSA-N
Canonical SMILES
CC1CCC2(C(CC(C(O2)C(C)C(=O)C3=CC=CN3)C)C)OC1CC4=NC5=C(C(=C(C=C5O4)Br)NC)C(=O)O
Isomeric SMILES
C[C@@H]1CC[C@]2([C@@H](C[C@H]([C@H](O2)[C@H](C)C(=O)C3=CC=CN3)C)C)O[C@@H]1CC4=NC5=C(C(=C(C=C5O4)Br)NC)C(=O)O
Solubility ( literature )

DMSO, Methanol, Dichloromethane

Compound Classification

polyether antibiotic;  calcium ionophore

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Expiration time
3Y
Retest time
3 Years
Applications

Nonfluorescent calcium ionophore used as a calibration standard for determining cytoplasmic calcium ions by fluorescent probes.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Antibiotics
Ionophores
Signal to sort
A

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A23187__4-Bromo
A23187__4-Bromo

A23187 free acid

A23187 free acid
Molecular Formula
C29H37N3O6
M.W.
523.62
CAS number
52665-69-7
MSDS
Source
Streptomyces chartreusis
Fermentek product Code
AFA-001
Brand/grade
For research
Appearance
White to off white powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 5mg/ml of Ethanol;
Clear colorless solution at 26mg/ml DMSO
Names and identifiers

Synonyms

  • Calcimycin,
  • Calcium Ionophore,
  • A23187

RTECS#   NO0600000

 

EU number
258-084-1
Chemical name
A23187
Description

A23187 ( Calcimycin ) is Mobile ion-carrier that forms stable complexes with divalent cations.

InChl Key
HIYAVKIYRIFSCZ-CVXKHCKVSA-N
Canonical SMILES
CC1CCC2(C(CC(C(O2)C(C)C(=O)C3=CC=CN3)C)C)OC1CC4=NC5=C(O4)C=CC(=C5C(=O)O)NC
Isomeric SMILES
C[C@H]1CCC2([C@@H](C[C@H]([C@H](O2)C(C)C(=O)C3=CC=CN3)C)C)O[C@H]1CC4=NC5=C(O4)C=CC(=C5C(=O)O)NC
Solubility ( literature )

DMSO, Methanol, Dichloromethane . Slightly soluble in water

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend +2 to +8°C storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Shipped at ambient temperature
Transport safety: Not Dangerous Goods; Not Regulated
Amber-glass vial.
Available since
Title
Comment:
Value
Additional tests, such as elemental analysis, may be included in CoA
Title
Deleted CAS numbers
Value
37259-87-3; 37263-57-3; 51257-80-8; 51310-65-7; 53095-21-9
Title
Transport information
Value
Not hazardous for transport
Title
TSE category
Value
F
Title
sig
Value
100105
Fermentek Product Category
Antibiotics
Cytotoxic agents
Ionophores
Signal to sort
A

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A23187__Free_Acid
A23187__Free_Acid

7 Aminoactinomycin D (7-AAD)

7 Aminoactinomycin D (7-AAD)
Molecular Formula
C62H87N13O16
M.W.
1 270.43
CAS number
7240-37-1
MSDS
Source
Semisynthetic Derivate of Actinomycin D
Fermentek product Code
7AD-001
Brand/grade
For research
Appearance
Purple powder
Purity by HPLC
≥97% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear purple solution at 20mg/ml DMSO
Names and identifiers

IUPAC name:
2,7-Diamino-N,N'-bis[(6S,9R,10S,13R,18aS)-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxohexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-4,6-dimethyl-3-oxo-3H-phenox azine-1,9-dicarboxamide

RTECS: 

AU1579000

 

EU number
635-285-6
Chemical name
7-Amino-Actinomycin-D
Description

(7-AAD) 7-Amino-Actinomycin-D is produced synthetically from natural Actinomycin D. (7-AAD) 7-Amino-Actinomycin-D binds to single stranded DNA. it is used, as a fluorescent dye, as a reagent capable to distinguish dead and live cells.

InChl Key
YXHLJMWYDTXDHS-UHFFFAOYSA-N
Canonical SMILES
CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=CC(=C(C4=C3N=C5C(=C(C(=O)C(=C5O4)C)N)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)C)N
Solubility ( literature )

Dichloromethane, DMSO, Methanol. Slightly soluble in water

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Transport safety: class 6.1 PG II
Available since
Title
Transport information
Value
Pg II
Fermentek Product Category
Antibiotics
Research field: Cancer
Apoptosis related
Anti Tumor agents
DNA replication inhibitors
Research field: Signal Transduction
Signal to sort
A

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7-_Amino-Actinomycin_D
7-_Amino-Actinomycin_D

17-DMAG

17-DMAG
Molecular Formula
C32H48N4O8
M.W.
616.75
CAS number
467214-20-6
MSDS
Source
Semisynthetic Derivate of Geldanamycin
Fermentek product Code
17D-001
Brand/grade
For research
Appearance
Purple powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear purple solution at 25mg/ml DMSO; Clear purple solution at 10mg/ml Ethanol
Names and identifiers

Synonyms:

  • 17-DMAG
  • Alvespimycin
  • 17-Dimethylaminoethylamino-17-demethoxygeldanamycin

RTECS: LX8922000

ECHA Number: 154-807-9

Chemical name
17-dimethylaminoethylamino-17-demethoxy-geldanamycin
Description

17-DMAG, also known as Alvespimycin, is a semisynthetic derivate of Geldanamycin, of less hepatotoxicity, improved water solubility.

17-DMAG is an ansamycin antibiotic which binds to Hsp90 (Heat Shock Protein 90) and alters it function.

InChl Key
KUFRQPKVAWMTJO-LMZWQJSESA-N
Canonical SMILES
CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)C)OC)OC(=O)N)C)C)O)OC
Isomeric SMILES
C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\C=C(\C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)/C)OC)OC(=O)N)\C)C)O)OC
Solubility ( literature )

DMSO, Methanol, Ethanol

Compound Classification
  • Benzoquinone ansamycin class antibiotic
  • Geldanamycin derivate
  • HSP90 inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

HSP-90 inhibitor; potential anti-cancer drug

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Transport safety: Not Dangerous Goods; Not Regulated
Available since
Title
Harmonized Tariff Code
Value
294190
Title
Transport safety information
Value
Not hazardous for transport
Title
Target
Value
HGF​/SF-​mediated Met tyrosine kinase
Title
Target
Value
ATP-​binding site of amino-​terminal domain region of HSP 90
Title
CN code
Value
29419000
Fermentek Product Category
Antibiotics
Anti Tumor agents
Enzyme-inhibitors
HSP90 inhibitors
Research Area: Stem Cells
Research field: Cancer
Signal to sort
D

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17-DMAG
17-DMAG

17-AAG

17-AAG (Tanespimycin)
Molecular Formula
C31H43N3O8
M.W.
585.69
CAS number
75747-14-7
MSDS
Source
Semisynthetic derivate of Geldanamycin
Fermentek product Code
17A-001
Brand/grade
For research
Appearance
Purple powder
Purity by HPLC
≥97% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear purple solution at 10mg/ml Methanol
Names and identifiers

Synonyms

  • Tanespimycin
  • 17-(Allylamino)-17-demethoxy- geldanamycin
  • 17AAG

IUPAC name
[(3S,5S,6R,7S,8E,10R,11S,12E,14E)-21-(allylamino)-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-8,12,14,18,21-pentaen-10-yl] carbamate

RTECS #
LX8932000

Chemical name
17-Demethoxy-17-allylaminogeldanamycin;
Description

17AAG, also known as "Tanespimycin", is an ansamycin antibiotic which binds to Hsp90 (Heat Shock Protein 90) and alters it function.

17AAG is less hepatotoxic than Geldanamycin.

 

InChl Key
AYUNIORJHRXIBJ-TXHRRWQRSA-N
Canonical SMILES
CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC
Isomeric SMILES
C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\C=C(\C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)/C)OC)OC(=O)N)\C)C)O)OC
Solubility ( literature )

DMSO, Methanol. The solubility of 17-AAG in DMSO is >10 mM. General tips for obtaining a higher concentration: Heating to 37°C and using ultrasonic bath is advisable.

Compound Classification
  • Benzoquinone  ansamycin antibiotic.
  • Geldanamycin derivate.
  • HSP90 inhibitor.
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Retest time
3 Years
Applications

This compound was mentioned as an anticancer medicine. Geldanamycin derivates all interfere with heat-shock proteins, especially HSP90. 17-AAG belongs to a class of drugs called heat shock protein 90 (Hsp90) inhibitors.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Transport safety: Not Dangerous Goods; Not Regulated
Available since
Title
TSE category
Value
S
Title
Transport information
Value
NDG
Title
CN code
Value
29419000
Fermentek Product Category
Antibiotics
Research field: Cancer
HSP90 inhibitors
Cancer Related Compounds
Anti Tumor agents
Research Area: Stem Cells
Signal to sort
A

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17-AAG__Tanespimycin
17-AAG__Tanespimycin

15-Acetoxyscirpenol

15-Acetoxyscirpenol
Molecular Formula
C17H24O6
M.W.
324.37
CAS number
2623-22-5
MSDS
Source
Semisynthetic
Fermentek product Code
15A-001
Brand/grade
For research
Appearance
White to off white powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10 mg/ml Methanol;
Clear colorless solution at 10 mg/ml DMSO
Names and identifiers

Synonyms

MAS

15-Acetoxyscirpenol

15-Monoacetoxyscirpenol

15- Deacetylanguidin

4- Deacetylanguidin

IUPAC names:  15-Acetoxyscirpenol

Chemical names: 15-Mono-O-acetylscirpenol;    Deacetylanguidin;    15-Acetoxyscirpenol;

Systematic Name:  Trichothec-9-ene-3-alpha,4-beta,15-triol, 12,13-epoxy-, 15- acetate

RTECS: YD0111000

EU number
636-756-9
Chemical name
15-Acetoxyscirpenol;
Description

MAS (15-Acetoxyscirpenol) is a Trichothecene class mycotoxin. It is closely related to DAS (Diacetoxyscirpenol)

InChl Key
IRXDUBNENLKYTC-DIRMQTSCSA-N
Canonical SMILES
CC1=CC2C(CC1)(C3(C(C(C(C34CO4)O2)O)O)C)COC(=O)C
Isomeric SMILES
CC1=C[C@@H]2[C@](CC1)(C3([C@@H]([C@H]([C@H](C34CO4)O2)O)O)C)COC(=O)C
Solubility ( literature )

Soluble in moderately polar solvents, such as chloroform, diethyl ether, ethyl acetate, and acetone

Compound Classification

Trichothecene

Mycotoxin

Apoptosis inducer

UNSPSC:

123521 Chemicals, including biochemicals.

121615 Chemicals, Additives, Indicators and reagents    

85151701 Healthcare Services;  Food and nutrition services; Food policy planning and aid; Food standards

85131703  Biomedical research services

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

MAS, as many other anguidine derivates exhibits a strong antimitotic effect,

Disclaimer
Semi-Synthetic
Degree
Grain
Ingredient type
Fermentek product
Title
Transport information
Value
Pg III
Title
Deleted CAS Numbers
Value
174421-33-1; 852222-55-0
Title
CN code
Value
n.a.
Title
CN code
Value
n.a.
Title
C-L inventory
Value
Y
Fermentek Product Category
Food Safety
Food Safety - Sub
Mycotoxins
Food Safety Related
Trichocothecenes
Antibiotics
Cytotoxic agents
Research field: Cancer
Apoptosis related
Signal to sort
A

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15-Acetoxyscirpenol
15-Acetoxyscirpenol animation
15- Acetoxyscirpenol bottle
15-Acetoxyscirpenol
15-Acetoxyscirpenol animation
15- Acetoxyscirpenol bottle

Actinomycin D (Dactinomycin)

Actinomycin D (Dactinomycin)
Molecular Formula
C62H86N12O16
M.W.
1 255.42
CAS number
50-76-0
MSDS
Source
Streptomyces parvulus
Fermentek product Code
ACT-001
Brand/grade
For research
Appearance
Red Shiny to Orange-Red Crystals
Purity by HPLC
≥ 95% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear orange solution at 50mg/ml DMSO;
Clear orange solution at 10mg/ml Methanol
Names and identifiers

 

Synonyms:

  • Actinomycin IV 
  • Actinomycin C1
  • Dactinomycin
  • Cosmegen
  • Oncostatin K

Chemical names:

IUPAC: 2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide

RTECS#: AU1575000

EU number
200-063-6
Description

Actinomycin D is an antibiotic, a member of Actinomycins group, derived from Streptomyces parvullus. Actinomycin D binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines.

InChl Key
RJURFGZVJUQBHK-IIXSONLDSA-N
Canonical SMILES
CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C
Isomeric SMILES
C[C@@H]1[C@@H](C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N(CC(=O)N([C@H](C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)N[C@H]6[C@H](OC(=O)[C@@H](N(C(=O)CN(C(=O)[C@@H]7CCCN7C(=O)[C@H](NC6=O)C(C)C)C)C)C(C)C)C)N)C
Solubility ( literature )

Actinomycin D is soluble in Dichloromethane or Methanol.

Compound Classification

Oligopeptide antibiotic;

RNA polymerase inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Very photo-sensitive.
Retest time
3 Years
Applications

Inhibitor of DNA-primed RNA polymerase and DNA polymerase. An apoptosis inducer. Antineoplastic drug.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Shipped in amber-glass vials
Title
Depreciated CAS Numbers
Value
1402-51-3; 1402-58-0; 1421227-25-9;
Title
Transport information
Value
PG II
Title
sig
Value
114666
Title
TSE
Value
F
Title
CN code
Value
29419000
Fermentek Product Category
Antibiotics
Cytotoxic agents
Research field: Cancer
Signal to sort
A

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Actinomycin_D
Actinomycin_D
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