17-DMAG
Molecular Formula
C32H48N4O8
M.W.
616.75
CAS number
467214-20-6
MSDS
Details
Source
Semisynthetic Derivate of Geldanamycin
Fermentek product Code
17D-001
Brand/grade
For research
Specifications
Appearance
Purple powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
152°C-162°C
Solubility test
Clear purple solution at 25mg/ml DMSO; Clear purple solution at 10mg/ml Ethanol
Chemical identification
Names and identifiers
Synonyms:
- 17-DMAG
- Alvespimycin
- 17-Dimethylaminoethylamino-17-demethoxygeldanamycin
RTECS: LX8922000
Chemical name
17-dimethylaminoethylamino-17-demethoxy-geldanamycin
Description
17-DMAG, also known as Alvespimycin, is a semisynthetic derivate of Geldanamycin, of less hepatotoxicity, improved water solubility.
17-DMAG is an ansamycin antibiotic which binds to Hsp90 (Heat Shock Protein 90) and alters it function.
InChl Key
KUFRQPKVAWMTJO-LMZWQJSESA-N
Canonical SMILES
CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)C)OC)OC(=O)N)C)C)O)OC
Isomeric SMILES
C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\C=C(\C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)/C)OC)OC(=O)N)\C)C)O)OC
Further Information
Solubility ( literature )
DMSO, Methanol, Ethanol
Compound Classification
- Benzoquinone ansamycin class antibiotic
- Geldanamycin derivate
- HSP90 inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications
HSP-90 inhibitor; potential anti-cancer drug
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Composition
Ingredient type
Fermentek product
Supply related information
Transport safety: Not Dangerous Goods; Not Regulated
Special Info
Available since
Other Fields
Title
Harmonized Tariff Code
Value
294190
Title
Transport safety information
Value
Not hazardous for transport
Title
Target
Value
HGF/SF-mediated Met tyrosine kinase
Title
Target
Value
ATP-binding site of amino-terminal domain region of HSP 90
Title
CN code
Value
29419000
Fermentek Product Category
Signal to sort
D
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