Antibiotics are antimicrobial compounds used in the treatment and prevention of bacterial infection. They can either kill or they can inhibit the growth of bacteria. Several antibiotics are also effective against fungi and protozoans. Some are toxic to humans and animals, even when given in therapeutic dosages. Antibacterial antibiotics are commonly classified based on their mechanism of action, chemical structure, or spectrum of activity. Most antibiotics target bacterial metabolic functions or growth processes. Those antibiotics that interfere with the function of essential bacterial enzymes, or that target the bacterial cell wall or the cell membrane, are usually bactericidal. Those that target protein synthesis are usually bacteriostatic. Further categorizations can be made based on target specificity. Use of antibiotics is essential in retaining the purity of particular selection factors in populations of cells. In recent years antibiotics have been found to be valuable in a wide range of life science disciplines. Fermentek has had particular success in manufacturing antibiotics using fermentation processes.

Enterocin (Vulgamycin)

Enterocin (Vulgamycin)
Molecular Formula
C22H20O10
M.W.
444.40
CAS number
59678-46-5
MSDS
Source
Streptomyces sp.
Fermentek product Code
ENT-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml of DMSO, Clear colorless solution at 10mg/ml of Methanol
Names and identifiers

Synonyms:

  • Enterocin
  • Vulgamycin

Chemical names:

  • (3R,4aR,5S,6S,7S,7aS,8R)-7-Benzoylhexahydro-4a,6,7a,8-tetrahydroxy-5-(4-methoxy-2-oxo-2H-pyran-6-yl)-3,6-methanocyclopenta[c]pyran-1(3H)-one (ACI)
  • 3,6-Methanocyclopenta[c]pyran-1(3H)-one, 7-benzoylhexahydro-4a,6,7a,8-tetrahydroxy-5-(4-methoxy-2-oxo-2H-pyran-6-yl)-, [3R-(3α,4aβ,5α,6β,7β,7aβ,8R*)]- (ZCI)   (after SciFinder)
  • (3R,4aR,5S,6S,7S,7aS,8R)-7-Benzoyl-4a,6,7a,8-tetrahydroxy-5-(4-methoxy-6-oxo-6H-pyran-2-yl)hexahydro-3,6-methanocyclopenta[c]pyran-1(3H)-one  (after Wikipedia)

IUPAC:

RTECS# PB9245500

EU number
Not listed as on dec-2023
InChl Key
CTBBEXWJRAPJIZ-VKMWXFLYSA-N
Canonical SMILES
COC1=CC(=O)OC(=C1)C2C3(CC4C(C2(C(C3(C(=O)O4)O)C(=O)C5=CC=CC=C5)O)O)O
Isomeric SMILES
COC1=CC(=O)OC(=C1)[C@@H]2[C@@]3(C[C@@H]4C([C@]2([C@@H]([C@]3(C(=O)O4)O)C(=O)C5=CC=CC=C5)O)O)O
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Protect from moisture!
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
UN no.: none (not regulated)
Shipped at ambient temperature
Transport safety: Not Dangerous Goods; Not Regulated
Available since
Fermentek Product Category
Antibiotics
Anti Bacterial

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Price
$1.00
Enterocin
Enterocin

Ibotenic acid

Ibotenic acid
Molecular Formula
C5H6N2O4
M.W.
158.11
CAS number
2552-55-8
MSDS
Source
Synthetic
Fermentek product Code
IBO-001
Brand/grade
For research
Appearance
White to Off White powder
Purity by HPLC
≥95% ; refer to CoA for more data
Purity By TLC
≥95% ; refer to CoA for more data
Solubility test
Clear colorless solution at 1mg/ml of Water
Names and identifiers

Synonyms:

▪ Ibotenic acid
▪ Pramuscimol
▪ 5-Isoxazoleacetic acid, alpha-amino-2,3-dihydro-3-oxo-
▪ α-Amino-3-hydroxy-5-isoxazoleacetic acid
▪ (S)-2-amino-2-(3-oxo-2,3-dihydroisoxazol-5-yl)acetic acid

Chemical names:

IUPAC:

Amino(3-oxo-2,3-dihydro-1,2-oxazol-5-yl)acetic acid
 

RTECS# NY2100000

ECHA Number: 622-405-7

EU number
622-405-7
Chemical name
Amino(3-oxo-2,3-dihydro-1,2-oxazol-5-yl)acetic acid
InChl Key
IRJCBFDCFXCWGO-UHFFFAOYSA-N
Canonical SMILES
C1=C(ONC1=O)C(C(=O)O)N
Isomeric SMILES
Not available
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Protect from moisture!
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Available since
Fermentek Product Category
Antibiotics
Ibotenic acid
Ibotenic acid

Leupeptin hemisulfate

Leupeptin hemisulfate
Molecular Formula
C20H38N6O4 1/2 (H2SO4)
M.W.
475.60
CAS number
103476-89-7
MSDS
Source
Synthetic
Fermentek product Code
LEU-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥96% ; refer to CoA for more data
Solubility test
Clear colorless to faint yellow solution at 50mg/ml of Water
Names and identifiers

Synonyms:

 

  • N-acetyl-L-leucyl-L-leucyl-L-argininal hemisulfate
  • L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-formylbutyl]-  hemisulfate
  • L-Leucinamide, N-acetyl-L-leucyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-, (S)-  hemisulfate
  • N-Acetyl-L-leucyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-formylbutyl]-L-niacinamide     hemisulfate
  • Acetyl-L-leucyl-L-leucyl-L-argininal
  • Leupeptin hemisulfate
  • 55123-66-5: parent compound CAS number (Leupeptin)

Chemical names:

IUPAC:

(2S)-2-acetamido-N-[(2S)-1-[[(2S)-5-(diamino methylidene amino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-4-methylpentanamide

RTECS#  

EU number
600-443-5
Chemical name
(2S)-2-acetamido-N-[(2S)-1-[[(2S)-5-(diamino methylidene amino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-4-methylpentanamide
Description

Leupeptin is a membrane-permeable reversible protease inhibitor of serine and cysteine proteases. Leupeptin inhibits plasmin, trypsin, papain, kallikrein, cathepsin B, and calpain.
Leupeptin is also a lysosomal inhibitor.

Chemically, Leupeptin is a tripeptide.

 

InChl Key
CIPMKIHUGVGQTG-VFFZMTJFSA-N
Canonical SMILES
CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CCCN=C(N)N)C=O)NC(=O)C.CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CCCN=C(N)N)C=O)NC(=O)C.OS(=O)(=O)O
Isomeric SMILES
CC(C)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C=O)NC(=O)C.CC(C)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C=O)NC(=O)C.OS(=O)(=O)O
Solubility ( literature )

Reportedly, Salts of leupeptin are reported to be soluble in water, ethanol, acetic acid, and DMF.

Compound Classification

Tripeptide

cysteine endopeptidase inhibitor which interferes with the action of any calpain.

A cysteine protease inhibitor that inhibits cathepsin B

A protease inhibitor that restricts the action of a serine protease.

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Fermentek Product Category
Antibiotics
Anti Viral
Others

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Price
$1.00
Leupeptin hemisulfate
Leupeptin hemisulfate

Melittin

Melittin
Molecular Formula
C131H229N39O31
M.W.
2 846.47
CAS number
20449-79-0
MSDS
Source
Bee venom (Natural)
Fermentek product Code
MEL-001
Brand/grade
For research
Appearance
White to off white powder
Purity by HPLC
≥ 98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 5mg/ml of water
Names and identifiers

Synonyms:

  • Forapine
  • Honeybee melittin
  • Bee venom melittin
  • Melittin I

Chemical names:

IUPAC:

H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH

ECHA Number: 629-303-1

EU number
629-303-1
Chemical name
H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH
Description

Melittin is a pore-forming toxic 26-amino-acid polypeptide that occurs in the venom of honey bees. Melittin constitutes about 40% to 60% (by weight) of that venom. 

InChl Key
VDXZNPDIRNWWCW-JFTDCZMZSA-N
Canonical SMILES
CCC(C)C(C(=O)NCC(=O)NC(C)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(C(C)O)C(=O)NC(C(C)O)C(=O)NCC(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)NC(C)C(=O)NC(CC(C)C)C(=O)NC(C(C)CC)C(=O)NC(CO)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NC(C(C)CC)C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)N)NC(=O)CN
Isomeric SMILES
CC[C@H](C)[C@@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC2=CNC3=CC=CC=C32)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N)NC(=O)CN
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Hygroscopic substance
Avoid exposing to strong direct light.
Protect from moisture!
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Fermentek Product Category
Antibiotics
Others

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Price
$1.00
Melittin
Melittin

Mitomycin C [1mg Mitomycin C + 24mg NaCl]

Mitomycin C [1mg Mitomycin C + 24mg NaCl]
Molecular Formula
C15H18N4O5 (for Mitomycin C)
M.W.
334.33
CAS number
50-07-7
MSDS
Source
Streptomyces caespitosus
Fermentek product Code
MIT-003
Brand/grade
For research
Appearance
Grey or purple or blue powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear blue to purple solution at 12.5mg/ml water
Names and identifiers

Synonyms:

 

  • mutamycin
  • ametycin, 
  • mitocin-C

Chemical names:

IUPAC:

{11-Amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl}methyl carbamate

RTECS# CN0700000

EU number
200-008-6
Chemical name
{11-Amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl}methyl carbamate
Description

Mitomycin C is an antitumor antibiotic that binds covalently to DNA. Mitomycin C has also antibacterial properties. In this product version, Mitomycin C is mixed with Sodium Chloride in order to improve solubility and stability. The ratio is Mitomycin C: 1 part (by weight), Sodium chloride 24 parts  (by weight). Data on this page refer to pure Mitomycin C.

InChl Key
NWIBSHFKIJFRCO-WUDYKRTCSA-N
Canonical SMILES
CC1=C(C(=O)C2=C(C1=O)N3CC4C(C3(C2COC(=O)N)OC)N4)N
Isomeric SMILES
CC1=C(C(=O)C2=C(C1=O)N3C[C@H]4[C@@H]([C@@]3([C@@H]2COC(=O)N)OC)N4)N
Solubility ( literature )

Soluble is Methanol; Soluble in water.

Compound Classification

Indolequinone antibiotic.

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Protect from moisture!
Retest time
3 Years
Applications

Mitomycin C is also available as a pure compound.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient Reference
Mitomycin C
Ingredient Other
Mitomycin C
Ingredient type
Fermentek product
Ingredient amount
4 percent by weight
Ingredient Other
Sodium Chloride
Ingredient type
Fermentek product
Ingredient amount
96% by weight
Shipped at ambient temperature
Transport safety: class 6.1 PG II
Fermentek Product Category
Antibiotics
Cytotoxic agents

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Mitomycin C [1mg Mitomycin C + 24mg NaCl]
Mitomycin_C.gif
Mitomycin C [1mg Mitomycin C + 24mg NaCl]
Mitomycin_C.gif

Nourseothricin sulfate

Nourseothricin sulfate
Molecular Formula
C19H36N8O12S
M.W.
600.60
CAS number
96736-11-7
MSDS
Source
Streptomyces sp.
Fermentek product Code
NOU-001
Brand/grade
For research
Appearance
White to faint brown powder
Purity by HPLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless to faint yellow solution at 200mg/ml Water
Names and identifiers

Synonyms:

 

  • NTC
  • ClonNAT
  • [(2R,3R,4S,5R,6R)-6-[[(3aS,7R,7aS)-7-hydroxy-4-oxo-1,3a,5,6,7,7a-hexahydroimidazo[4,5-c]pyridin-2-yl]amino]-5-[[(3S)-3,6-diaminohexanoyl]amino]-4-hydroxy-2-(hydroxymethyl)oxan-3-yl] carbamate;sulfuric acid
  • Streptothricin sulfate

Chemical names:

IUPAC:

[(2R,3R,4S,5R,6R)-6-[[(3aS,7R,7aS)-7-hydroxy-4-oxo-1,3a,5,6,7,7a-hexahydroimidazo[4,5-c]pyridin-2-yl]amino]-5-[[(3S)-3,6-diaminohexanoyl]amino]-4-hydroxy-2-(hydroxymethyl)oxan-3-yl] carbamate;sulfuric acid 

RTECS# RD4240000

ECHA: 635-448-1

Chemical name
[(2R,3R,4S,5R,6R)-6-[[(3aS,7R,7aS)-7-hydroxy-4-oxo-1,3a,5,6,7,7a-hexahydroimidazo[4,5-c]pyridin-2-yl]amino]-5-[[(3S)-3,6-diaminohexanoyl]amino]-4-hydroxy-2-(hydroxymethyl)oxan-3-yl] carbamate;sulfuric acid
Description

Nourseothricin belongs to the Streptothricin group of aminonucleoside antibiotics. Its main application is - a selection tool in genetic engineering. It is effective for mammalian cells, yeasts and fungi, protozoa, bacteria, and blue-green algae.

Chemically, Nourseothricin is a mixture of closely related variants Streptothricin C, D, E, and F, differing in the length of ß-lysine homopolymer, with 1 to 4 ß-lysine residuals.

The data in this webpage, including the molecular image, belong to the Nourseothricin C (One Lysine residual)

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Fermentek Product Category
Antibiotics
Anti Fungal
Anti Bacterial
Anti Viral

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Nourseothricin sulfate
Nourseothricin sulfate

Actinomycin D (Dactinomycin)

Actinomycin D (Dactinomycin)
Molecular Formula
C62H86N12O16
M.W.
1 255.42
CAS number
50-76-0
MSDS
Source
Streptomyces parvulus
Fermentek product Code
ACT-001
Brand/grade
For research
Appearance
Red Shiny to Orange-Red Crystals
Purity by HPLC
≥ 95% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear orange solution at 50mg/ml DMSO;
Clear orange solution at 10mg/ml Methanol
Names and identifiers

 

Synonyms:

  • Actinomycin IV 
  • Actinomycin C1
  • Dactinomycin
  • Cosmegen
  • Oncostatin K

Chemical names:

IUPAC: 2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide

RTECS#: AU1575000

EU number
200-063-6
Description

Actinomycin D is an antibiotic, a member of Actinomycins group, derived from Streptomyces parvullus. Actinomycin D binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines.

InChl Key
RJURFGZVJUQBHK-IIXSONLDSA-N
Canonical SMILES
CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C
Isomeric SMILES
C[C@@H]1[C@@H](C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N(CC(=O)N([C@H](C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)N[C@H]6[C@H](OC(=O)[C@@H](N(C(=O)CN(C(=O)[C@@H]7CCCN7C(=O)[C@H](NC6=O)C(C)C)C)C)C(C)C)C)N)C
Solubility ( literature )

Actinomycin D is soluble in Dichloromethane or Methanol.

Compound Classification

Oligopeptide antibiotic;

RNA polymerase inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Very photo-sensitive.
Retest time
3 Years
Applications

Inhibitor of DNA-primed RNA polymerase and DNA polymerase. An apoptosis inducer. Antineoplastic drug.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Shipped in amber-glass vials
Title
Depreciated CAS Numbers
Value
1402-51-3; 1402-58-0; 1421227-25-9;
Title
Transport information
Value
PG II
Title
sig
Value
114666
Title
TSE
Value
F
Title
CN code
Value
29419000
Fermentek Product Category
Antibiotics
Cytotoxic agents
Research field: Cancer
Signal to sort
A

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Actinomycin_D
Actinomycin_D

Monascorubrin

Monascorubrin
Molecular Formula
C23H26O5
M.W.
382.40
CAS number
13283-90-4
MSDS
Source
Monascus pilosus
Fermentek product Code
MOR-001
Brand/grade
For research
Appearance
Orange Powder
Purity by HPLC
≥ 98% ; refer to CoA for more data
Purity By TLC
Single spot on TLC plates, by multiple methods.
Solubility test
Clear orange to dark orange solution at 10mg/ml of DMSO or Methanol
Names and identifiers

Synonyms:

  • Monascorubrin
  • Monasred

Chemical names:

IUPAC:

  • 9a-Methyl-3-octanoyl-6-[(1E)-1-propen-1-yl]-2H-furo[3,2-g]isochromene-2,9(9aH)-dione

RTECS# Not listed

EU number
Not on ECHA as on 11-2023
Chemical name
9a-Methyl-3-octanoyl-6-[(1E)-1-propen-1-yl]-2H-furo[3,2-g]isochromene-2,9(9aH)-dione
Description

An orange pigment from Monascus pilosus, exhibiting anti-tumor activity.

InChl Key
IIPVSGPTPPURBD-HAOIVFDCSA-N
Canonical SMILES
CCCCCCCC(=O)C1=C2C=C3C=C(OC=C3C(=O)C2(OC1=O)C)C=CC
Isomeric SMILES
CCCCCCCC(=O)C1=C2C=C3C=C(OC=C3C(=O)[C@@]2(OC1=O)C)/C=C/C
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Protect from light !
Keep the lid tightly closed.
Other vendors may recommend higher temperatures for storage.
Protect from moisture!
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Fermentek Product Category
Antibiotics

Quote for

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Price
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Monascorubrin
Monascorubrin

Nigericin (free)

Nigericin (free)
Molecular Formula
C40H68O11
M.W.
724.96
CAS number
28380-24-7
MSDS
Source
Streptomyces hygroscopicus
Fermentek product Code
NIG-002
Brand/grade
For research
Appearance
White to off white powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Names and identifiers

Synonyms: 

Polyetherin A; Azalomycin M; Helexin C ; Antibiotic K178;  Antibiotic X-464

Chemical names:

IUPAC:

(2R)-2-[(2R,3S,6R)-6-[[(2S,4R,5R,6R,7R,9R)-2-[(2R,5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyloxan-2-yl]propanoic acid  

RTECS# QT6825000

EU number
686-881-8
Chemical name
Polyetherin A; Azalomycin M; Helexin C ; Antibiotic K178; Antibiotic X-464
Description

Nigericin is a polyether antibiotic which affects ion transport and ATPase activity in mitochondria.

Nigericin is produced by Streptomyces hygroscopicus. Nigericin, an ionophore and antibiotic, is supplied as a free acid. It is also available as a Na salt.sodium salt.

Nigericin is one of the compounds successfully tested as a feed additive, displaying a significant effect on milk production in cattle. In vitro, nigericin has broad biological activity against Gram positive bacteria, fungi, tumor cell lines and some viruses, including HIV.

InChl Key
DANUORFCFTYTSZ-SJSJOXFOSA-N
Canonical SMILES
O=C(O)C(C)C1OC(CCC1C)CC2OC3(OC(C)(CC3C)C4OC(C)(CC4)C5OC(CC5C)C6OC(O)(CO)C(C)CC6C)C(C)C(OC)C2
Isomeric SMILES
C[C@H]1CC[C@@H](O[C@H]1[C@@H](C)C(=O)O)C[C@@H]2C[C@H]([C@H]([C@@]3(O2)[C@@H](C[C@@](O3)(C)[C@H]4CC[C@@](O4)(C)[C@H]5[C@H](C[C@@H](O5)[C@@H]6[C@H](C[C@H]([C@@](O6)(CO)O)C)C)C)C)C)OC
Solubility ( literature )

DMSO, Ethanol, petrol ether. Not soluble in water

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Retest time
3 Years
Applications

Disrupts the membrane potential and stimulates ATPase activity in mitochondria.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Fermentek Product Category
Antibiotics
Research field: Cancer
Ionophores

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Larger quantities available. Please enquire
Price
$1.00
Nigericin (free)
Nigericin (free)

Fidaxomicin

Fidaxomicin
Molecular Formula
C52H74Cl2O18
M.W.
1 058.00
CAS number
873857-62-6
MSDS
Source
Dactylosporangium aurantiacum (An Actinobecterium)
Fermentek product Code
FID-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless to faint yellow solution at 1mg/ml of DMSO;
Clear colorless to faint yellow solution at 5 mg/ml of Methanol
Names and identifiers

Synonyms:

  • Dificid,
  • Dificlir, 
  • Clostomicin B1,
  • lipiarmicin,
  • lipiarmycin,
  • lipiarmycin A3, 
  • tiacumicin B

Chemical names:

IUPAC:   [(2R,3S,4S,5S,6R)-6-[[(3E,5E,8S,9E,11S,12R,13E,15E,18S)-12-[(2R,3S,4R,5S)-3,4-dihydroxy-6,6-dimethyl-5-(2-methylpropanoyloxy)oxan-2-yl]oxy-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyl-2-oxo-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl]methoxy]-4-hydroxy-5-methoxy-2-methyloxan-3-yl] 3,5-dichloro-2-ethyl-4,6-dihydroxybenzoate

RTECS#  Not available

EU number
692-555-6
Chemical name
Fidaxomicin
Description

Fidaxomicin is a narrow spectrum macrocyclic antibiotic, sourced from actinomycete Dactylosporangium aurantiacum. Fidaxomicin is non-systemic, meaning it is minimally absorbed into the bloodstream. This anti-bacterial agent  selectively acts against pathogenic Clostridium difficile bacteria which may infect the colon, while causing minimal damage to the natural intestinal microbial flora.

InChl Key
ZVGNESXIJDCBKN-UUEYKCAUSA-N
Canonical SMILES
CCC1C=C(C(CC=CC=C(C(=O)OC(CC=C(C=C(C1OC2C(C(C(C(O2)(C)C)OC(=O)C(C)C)O)O)C)C)C(C)O)COC3C(C(C(C(O3)C)OC(=O)C4=C(C(=C(C(=C4O)Cl)O)Cl)CC)O)OC)O)C
Isomeric SMILES
CC[C@H]1/C=C(/[C@H](C/C=C/C=C(/C(=O)O[C@@H](C/C=C(/C=C(/[C@@H]1O[C@H]2[C@H]([C@H]([C@@H](C(O2)(C)C)OC(=O)C(C)C)O)O)\C)\C)[C@@H](C)O)\CO[C@H]3[C@H]([C@H]([C@@H]([C@H](O3)C)OC(=O)C4=C(C(=C(C(=C4O)Cl)O)Cl)CC)O)OC)O)\C
Solubility ( literature )

Reportedly, Fidaxomicin is soluble in CHCl3(10 mg/ml), methanol(10 mg/ml), DMSO(1mg/ml); poor water solubility.

Compound Classification

UNSPSC:

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Transport safety: Not Dangerous Goods; Not Regulated
Available since
Title
depreciated CAS
Value
55352-58-4, 56645-60-4, 750595-89-2
Fermentek Product Category
Antibiotics
Cytotoxic agents
Protein synthesis inhibitors
Anti Bacterial
Research field: Signal Transduction
Signal to sort
F

Quote for

Larger quantities available. Please enquire
Price
$1.00
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