Leupeptin hemisulfate

Molecular Formula:

C20H38N6O4 1/2 (H2SO4)

CAS number:

103476-89-7

EU number:

600-443-5

Fermentek product code:

LEU

Source:

Synthetic

Brand/grade:

For research

Specifications

Appearance:

White to Off-White powder

Purity by HPLC:

≥96% ; refer to CoA for more data

Solubility test:

Clear colorless to faint yellow solution at 50mg/ml of Water

Chemical identification

Names and identifiers:

Synonyms:

N-acetyl-L-leucyl-L-leucyl-L-argininal hemisulfate
L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-formylbutyl]- hemisulfate
L-Leucinamide, N-acetyl-L-leucyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-, (S)- hemisulfate
N-Acetyl-L-leucyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-formylbutyl]-L-niacinamide hemisulfate
Acetyl-L-leucyl-L-leucyl-L-argininal
Leupeptin hemisulfate
55123-66-5: parent compound CAS number (Leupeptin)

Chemical names:

IUPAC:

(2S)-2-acetamido-N-[(2S)-1-[[(2S)-5-(diamino methylidene amino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-4-methylpentanamide

RTECS#

OH6240000 (Belongs to Leupeptins)

Description:

Leupeptin is a membrane-permeable reversible protease inhibitor of serine and cysteine proteases. Leupeptin inhibits plasmin, trypsin, papain, kallikrein, cathepsin B, and calpain.
Leupeptin is also a lysosomal inhibitor.

Chemically, Leupeptin is a tripeptide.

Molecular weight:

475.60

InChl Key:

CIPMKIHUGVGQTG-VFFZMTJFSA-N

Canonical SMILES:

CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CCCN=C(N)N)C=O)NC(=O)C.CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CCCN=C(N)N)C=O)NC(=O)C.OS(=O)(=O)O

Isomeric SMILES:

CC(C)C[[email protected]@H](C(=O)N[[email protected]@H](CC(C)C)C(=O)N[[email protected]@H](CCCN=C(N)N)C=O)NC(=O)C.CC(C)C[[email protected]@H](C(=O)N[[email protected]@H](CC(C)C)C(=O)N[[email protected]@H](CCCN=C(N)N)C=O)NC(=O)C.OS(=O)(=O)O

Further Information

Solubility ( literature ):

Reportedly, Salts of leupeptin are reported to be soluble in water, ethanol, acetic acid, and DMF.

Compound Classification:

Tripeptidecysteine endopeptidase inhibitor which interferes with the action of any calpain.A cysteine protease inhibitor that inhibits cathepsin BA protease inhibitor that restricts the action of a serine protease.

Storage, handling:

Store in a freezer upon arrival, at -10°C to -25°C

Open carefully.

Use the original container to store the product.

Keep the lid tightly closed.

Avoid exposing to strong direct light.

Other vendors may recommend higher temperatures for storage.

Protect from moisture!

Disclaimer:

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Composition

Ingredient type:

Fermentek product

Supply related information

Supply related comments:

Customs: Other Antibiotics-29419000

Customs: Laboratory reagents-38220000

Shipped at ambient temperature

Shipped in glass vials

Transport safety: Not Dangerous Goods; Not Regulated

Special Info

Available since:

2022