Angiogenesis is a process of creating new blood vessels in the body. Angiogenesis is a key factor in the development of hard cancers, which depend on a constantly growing supply of blood as they enlarge. Other diseases can be caused by insufficient blood supply to certain organs.

Among such conditions are diabetic ulcers, miscellaneous skin lesions, cardio-vascular diseases, and cerebrovascular events. It is believed that controlling the process of angiogenesis could lead to the development of therapies for such conditions.

Apicidin

Apicidin
Molecular Formula
C34H49N5O6
M.W.
623.80
CAS number
183506-66-3
Source
Fusarium sp.
Fermentek product Code
API-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
187°C-193°C
Solubility test
Clear colorless solution at 1 mg /ml Ethanol or DMSO
Names and identifiers

Synonyms:

  • apicidin C

IUPAC name:

  • (3S,6S,9S,12R)-3-[(2S)-butan-2-yl]-6-[(1-methoxyindol-3-yl)methyl]-9-(6-oxooctyl)-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetrone

RTECS XJ6094046 

EU number
635-755-0
Description

Apicidin is a mycotoxin which may occur naturally, as a result of Fusarium fungi growing on improperly stored foods.

Apicidin is a potent cell permeable inhibitor of histone deacetylase.

 

InChl Key
JWOGUUIOCYMBPV-GMFLJSBRSA-N
Canonical SMILES
CCC(C)C1C(=O)N2CCCCC2C(=O)NC(C(=O)NC(C(=O)N1)CC3=CN(C4=CC=CC=C43)OC)CCCCCC(=O)CC
Isomeric SMILES
CC[C@H](C)[C@H]1C(=O)N2CCCC[C@@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC3=CN(C4=CC=CC=C43)OC)CCCCCC(=O)CC
Solubility ( literature )

Ethanol, DMSO, Dichloromethane. Slightly soluble in water, methanol.

Compound Classification
  • Cyclic peptide antibiotic
  • Mycotoxin
  • Antiprotozoal
  • HDAC inhibitor
  • Angiogenesis inhibitor
Applications

Cyclic peptide antibiotic with broad spectrum antiparasitic and antiprotozoan activity. An histone deacetylase inhibitor, Anti-angiogenic; Apoptosis inductor.

Disclaimer
Refer to MSDS for further safety and handling instructions.
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Title
research fields
Value
Systemic lupus erythematosus; Autoimmune diseases; Rheumatoid arthritis; Histone deacetylation;
Title
Safety comments
Value
RTECS only specifies mutagenity. Whoever says it is toxic, has no data to support
Signal to sort
A