Alamethicin

Molecular Formula:

C92H150N22O25

CAS number:

27061-78-5

EU number:

608-040-6

Fermentek product code:

ALA

Source:

Trichoderma viride

Brand/grade:

For research

Specifications

Appearance:

Off White to Beige powder

Purity by HPLC:

4 main peaks, complies with literature

Purity By TLC:

≥98% ; refer to CoA for more data

Melting point:

252°C-272°C

Solubility test:

Clear colorless solution at 10mg/ml DMSO or Methanol

Chemical identification

Names and identifiers:

Synonyms: Antibiotic U 22324

RTECS: AY1900000

Description:

Alamethicin is a channel-forming ionophore. Used as a model for larger channel proteins since it can form voltage-gated ion channels in membranes.

Used in genetic engineering, development of mold-resistant crops

Chemically, it is a peptide of 20 amino acids. The product consists of a mixture of several isoforms, which may be slightly different in the amino-acids sequences, but possess the same activity.

Molecular weight:

1 964.30

InChl Key:

LGHSQOCGTJHDIL-UTXLBGCNSA-N

Canonical SMILES:

CC(C)CC(C(=O)NC(C)(C)C(=O)N1CCCC1C(=O)NC(C(C)C)C(=O)NC(C)(C)C(=O)NC(C)(C)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)N)C(=O)NC(CC2=CC=CC=C2)CO)NC(=O)CNC(=O)C(C)(C)NC(=O)C(C(C)C)NC(=O)C(C)(C)NC(=O)C(CCC(=O)N)NC(=O)C(C)NC(=O)C(C)(C)NC(=O)C(C)NC(=O)C(C)(C)NC(=O)C3CCCN3C(=O)C(C)(C)NC(=O)C

Isomeric SMILES:

C[C@@H](C(=O)N[C@@H](CCC(=O)N)C(=O)NC(C)(C)C(=O)N[C@@H](C(C)C)C(=O)NC(C)(C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)NC(C)(C)C(=O)NC(C)(C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC2=CC=CC=C2)CO)NC(=O)C(C)(C)NC(=O)[C@H](C)NC(=O)C(C)(C)NC(=O)[C@@H]3CCCN3C(=O)C(C)(C)NC(=O)C

Further Information

Solubility ( literature ):

DMSO, Methanol, Ethanol

Compound Classification:

Peptide antibiotic
Channel forming Ionophore

Storage, handling:

Store in a freezer upon arrival, at -10°C to -25°C

Hygroscopic substance.

Protect from moisture

Use the original container to store the product.

Keep the lid tightly closed.

Avoid exposing to strong direct light.

Applications:

Can mimic nerve action potential across artificial membranes

Disclaimer:

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Composition

Ingredient type:

Fermentek product

Special Info

Available since:

2004

Other Fields

Title:

Transport information

Value:

Pg III

Title:

Deleted CAS numbers

Value:

11051-59-5; 55739-76-9