Nivalenol
Details
Specifications
Chemical identification
IUPAC Name
(3β,4α,7α,12ξ)-3,4,7,15-Tetrahydroxy-12,13-epoxytrichothec-9-en-8-one
RTECS#
YD0167000
Nivalenol is a type - B trichothecene mycotoxin produced by various Fusarium species, such as Fusarium cerealis, Fusarium graminearum, Fusarium nivale. Besides the natural toxin produced directly by molds, Nivalenol may be also formed by higher plants and by mammals, as a product of biodegradation of other, related thrichothecenes.
Further Information
Dichloromethane, DMSO, Methanol. Slightly soluble in water
Chemical class:
Trichothecene mycotoxin
Nivalenol (0.01 mg/ml) induces apoptosis in HL60 cells (Ueno et al., 1995). Nivalenol was shown to inhibit protein synthesis in rabbit reticulocytes in vitro. Nivalenol inhibited the synthesis of nucleic acids in vitro.