- Antibiotic SL-2052
Wortmannin is a steroid metabolite of the fungus Talaromyces wortmannii. It is a specific covalent inhibitor of phosphoinositide 3-kinases. Wortmannin has been used as precursor of an experimental anti-cancer drug PX-866
DMSO, Methanol.Wortmannin is unstable in aqueous and ethanolic solutions.
- chemical class: Androstadiene.
- phospholipase D inhibitor.
- phosphatidylinositol 3-kinase inhibitor.
Wortmannin is an inhibitor of phosphatidyl-inositol 3-kinase Wortmannin inhibits the growth of mammary tumors despite the existence of a novel wortmannin-insensitive phosphatidylinositol-3-kinase. Wortmannin inhibits repair of DNA double-strand breaks in irradiated normal human cells. Wortmannin was shown to have enhancing influence on memory and impair learning abilities. .
United States Patent Application 20120114637
Wortmannin (lalpha,l lalpha)-l l-(acetyloxy)-l-(methoxymethyl)-2-oxaandrosta-5,8- dieno(6,5,4-bc)furan-3,7,17-trione) available from Fermentek Biotechnology is an antifungal antibiotic, that inhibits mTOR (Brunn et al., EMBO J, 15:5256-5267, 1996).