Fumitremorgin C is a tremorgenic mycotoxin isolated from Aspergillus fumigatus. Recent research has recognized Fumitremorgin C as a potent and specific inhibitor of the breast cancer resistance protein (BCRP/ABCG2) multidrug transporter. It reverses multidrug resistance mediated by BCRP and increases cytotoxicity of several anticancer agents in vitro.
Soluble in Ethanol, Methanol, DMF, DMSO Chloroform.
Negligible solubility ( 35 mg in 1 liter water @25°C) has been reported.
Breast cancer resistance protein inhibitor
Mammalian cell cycle inhibitors