Fumitremorgin C
Molecular Formula
C22H25N3O3
M.W.
379.46
CAS number
118974-02-0
MSDS
Details
Source
Aspergillus sp.
Fermentek product Code
FUC-001
Brand/grade
For research
Specifications
Appearance
White to off white powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml of Methanol or Acetonitrile
Chemical identification
Names and identifiers
IUPAC: (5aS,12S,14aS)-9-Methoxy-12-(2-methyl-1-propen-1-yl)-1,2,3,5a,6,11,12,14a-octahydro-5H,14H-pyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14-dione
RTECS# UY8709670
EU number
Not listed
Chemical name
Fumitremorgin C
Description
Fumitremorgin C is a tremorgenic mycotoxin isolated from Aspergillus fumigatus. Recent research has recognized Fumitremorgin C as a potent and specific inhibitor of the breast cancer resistance protein (BCRP/ABCG2) multidrug transporter. It reverses multidrug resistance mediated by BCRP and increases cytotoxicity of several anticancer agents in vitro.
InChl Key
DBEYVIGIPJSTOR-FHWLQOOXSA-N
Canonical SMILES
CC(=CC1C2=C(CC3N1C(=O)C4CCCN4C3=O)C5=C(N2)C=C(C=C5)OC)C
Isomeric SMILES
CC(=C[C@H]1C2=C(C[C@@H]3N1C(=O)[C@@H]4CCCN4C3=O)C5=C(N2)C=C(C=C5)OC)C
Further Information
Solubility ( literature )
Soluble in Ethanol, Methanol, DMF, DMSO Chloroform.
Negligible solubility ( 35 mg in 1 liter water @25°C) has been reported.
Compound Classification
Breast cancer resistance protein inhibitor
Mammalian cell cycle inhibitors
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Open carefully.
Keep the lid tightly closed.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Composition
Ingredient type
Fermentek product
Special Info
Available since
Other Fields
Title
Transport information
Value
Not hazardous goods. Nor regulated
Fermentek Product Category
Signal to sort
F
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