Nodularin
Molecular Formula
C41H60N8O10
M.W.
824.96
CAS number
118399-22-7
Source
Nodularia spumigena
Fermentek product Code
NOD-001
Brand/grade
For research
Appearance
White to brown powder
Purity by HPLC
≥95% ; refer to CoA for more data
Solubility test
Clear colorless to slight brown solution at 10mg/ml of DMSO;
Clear colorless to slight brown at 2mg/ml of Methanol
Names and identifiers

Synonyms:

 

  • Nodularin
  • Nodularin R
  • Cyclo[(Z)-2,3-didehydro-N-methyl-2-aminobutanoyl-erythro-3-methyl-D-β-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyl-3-aminodecanoyl-D-γ-glutamyl]

Chemical names:

IUPAC:

(2Z,5R,6S,9S,12S,13S,16R)-9-[3-(diaminomethylideneamino)propyl]-2-ethylidene-12-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dienyl]-1,6,13-trimethyl-3,7,10,14,19-pentaoxo-1,4,8,11,15-pentazacyclononadecane-5,16-dicarboxylic acid

HSDB:   7749   

RTECS# GU2294250

EU number
621-437-9
Chemical name
Nodularin
Description

Nodularins are potent toxins produced by the cyanobacterium Nodularia spumigena . This aquatic, photosynthetic cyanobacterium forms visible colonies that present as algal blooms in brackish water bodies.

InChl Key
IXBQSRWSVIBXNC-HSKGSTCASA-N
Canonical SMILES
CC=C1C(=O)NC(C(C(=O)NC(C(=O)NC(C(C(=O)NC(CCC(=O)N1C)C(=O)O)C)C=CC(=CC(C)C(CC2=CC=CC=C2)OC)C)CCCN=C(N)N)C)C(=O)O
Isomeric SMILES
C/C=C\1/C(=O)N[C@H]([C@@H](C(=O)N[C@H](C(=O)N[C@H]([C@@H](C(=O)N[C@H](CCC(=O)N1C)C(=O)O)C)/C=C/C(=C/[C@H](C)[C@H](CC2=CC=CC=C2)OC)/C)CCCN=C(N)N)C)C(=O)O
Solubility ( literature )
  • Methanol 2mg/ml
  • MeOH:Water 1:1 v:v 1mg/ml
  • EtOH, DMSO 10mg/ml
Compound Classification
  • Cyanotoxin
  • Cyclic Oligopeptide
  • Non ribosomal peptide
  • Non-protein-building aminoacids
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Applications
  • Potent inhibitor of protein phosphatases 1 and 2A (PP1 and PP2A).
  • Useful for affinity purification of PP2A Similar to Microcystin-LR (ICN Cat. No. 158379), but with increased water solubility.
  • Ref: 1. J. Cancer Res. Clin. Oncol., 116, 609-614 (1990).
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Fermentek Product Category
Cyanobacterial Toxins

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Price
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Nodularin
Nodularin