Equisetin
Molecular Formula
C22H31NO4
M.W.
373.49
CAS number
57749-43-6
MSDS
Source
Fusarium equiseti
Fermentek product Code
EQU-001
Brand/grade
For research
Appearance
Light tan to tan or off-white powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10 mg/ml of Methanol or DMSO
Names and identifiers

IUPAC:

(2S)-4-({(1S,2R,4aS,6R,8aR)-1,6-Dimethyl-2-[(1E)-1-propen-1-yl]-1,2,4a,5,6,7,8,8a-octahydro-1-naphthalenyl}carbonyl)-5-hydroxy-2-(hydroxymethyl)-1-methyl-1,2-dihydro-3H-pyrrol-3-one

RTECS KD7986000

EU number
303-396-6
Description

Antibiotic from Fusarium equiseti; derivative of N-methyl-2,4-pyrollidone

InChl Key
QNQBPPQLRODXET-HMHJLHGTSA-N
Canonical SMILES
CC=CC1C=CC2CC(CCC2C1(C)C(=C3C(=O)C(N(C3=O)C)CO)O)C
Isomeric SMILES
C/C=C/[C@@H]1C=C[C@@H]2C[C@@H](CC[C@H]2[C@]1(C)/C(=C\3/C(=O)[C@@H](N(C3=O)C)CO)/O)C
Solubility ( literature )

Equisetin is reported to be soluble in DMF or DMSO, moderately soluble in methanol or ethanol and poorly soluble in water.

Equisetin solubility as reported in an original patent,

  • in acetone of 660 mg./ml.,
  • in ethanol of 330 mg./ml.,
  • in methanol of 220 mg./ml.,
  • in hexane of 0.8 mg./ml.,
  • in water of 0.3 mg./ml.

Elemental analysis: C, 70.95; H, 8.39; N, 3.14;

Compound Classification

Chemical classification:

Tetramic acid class antibiotic.

Classification by Bioactivity:

HIV-integrase inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Applications

Equisetin inhibits some ATPases, and affects several energy related mitochondrial enzymes.

Equisetin was also shown to inhibit (in-vitro) HIV-1 integrase.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Amber-glass vial.
Available since
Title
Transport
Value
Not regulated
Title
Animal rawmat
Value
No
Signal to sort
E