- Bongkrekic Acid
- Flavotoxin A
Disambiguation: Regarding BA, Bongrekic acid, iso-Bongkrekic acid, Flavotoxin A, Toxiflavin.
Flavotoxin A is a Synonym of BA.
Bongkrekic acid (BA) and iso-Bongkrekic acid (iso-BA) are closely related compounds, sharing identic chemical formulas.
Toxiflavin which occurs together with BA and iso-BA is indeed a chemically unrelated compound.
- (6R,17S)-20-(carboxymethyl)-6-methoxy-2,5,17-trimethyldocosa-2,4,8,10,14,18,20-heptaenedioic acid
Bongkrekic acid is a respiratory toxin produced by Burkholderia gladioli (aka Pseudomonas marginata). Bongkrekic acid has a unique mechanism of toxicity among the mitochondrial toxins: it inhibits adenine nucleotide translocase (ANT) rather than the electron transport chain. It is a proven cause of mass deaths by contaminating certain Far-Eastern foods based on fermented coconut.
- Solubility in Water: ~ 1 mg/ml
- Solubility Notes: ~100 mg/ml in DMSO
- Chemical classification:
- Polyunsaturated tricarboxylic acid
- Glutathione transferase inhibitor
- ATP/ADP translocase inhibitor
Bongcrekic acid is an inhibitor of adenine nucleotide translocator, which inhibits apoptosis, and is thus an important tool for the mechanistic investigation of apoptosis.
Supply related information
Bongkrekic Acid induces Selective Cytotoxicity in Tumor Cells, revealed by CCK-8
Kano Arihiro, Kamita Moses Kibunja, Iwasaki Takuma, Shindo Mitsuru
Chemistry, Medicine, Biochemistry and Biophysics Reports
Bongkrekic acid facilitates glycolysis in cultured cells and induces cell death under low glucose conditions
Arihiro Kano, Takuma Iwasaki, M. Shindo