Bongkrekic acid (as solution)
Molecular Formula
C28H38O7
M.W.
486.60
CAS number
11076-19-0
MSDS
Details
Source
Pseudomonas gladioli
Fermentek product Code
BON-001
Brand/grade
For research
Specifications
Appearance
Clear colorless solution
Purity by HPLC
≥95% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Chemical identification
Names and identifiers
Synonyms:
- Bongkrekic Acid
- Flavotoxin A
Chemical names:
IUPAC:
- (6R,17S)-20-(carboxymethyl)-6-methoxy-2,5,17-trimethyldocosa-2,4,8,10,14,18,20-heptaenedioic acid
RTECS: JR1230000
ECHA Number: 998-673-7
EU number
Not assigned
Chemical name
Bongkrekic acid
Description
Supplied as 1mg/ml solution dissolved in 0.01M Tris buffer pH 7.5.
InChl Key
SHCXABJSXUACKU-WUTQZGRKSA-N
Canonical SMILES
CC(CC=CCCC=CC=CCC(C(=CC=C(C)C(=O)O)C)OC)C=CC(=CC(=O)O)CC(=O)O
Isomeric SMILES
CC(C/C=C/CC/C=C/C=C\CC(/C(=C\C=C(/C)\C(=O)O)/C)OC)/C=C/C(=C\C(=O)O)/CC(=O)O
Further Information
Solubility ( literature )
- Solubility in Water: ~ 1 mg/ml
- Solubility Notes: ~100 mg/ml in DMSO
Compound Classification
- Chemical classification:
- Polyunsaturated tricarboxylic acid
Bioactivity:
- Glutathione transferase inhibitor
- ATP/ADP translocase inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
2 Years
Applications
Bongcrekic acid is an inhibitor of adenine nucleotide translocator, which inhibits apoptosis, and is thus an important tool for the mechanistic investigation of apoptosis.
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Composition
Ingredient type
Fermentek product
Ingredient amount
1 mg/ml in 0.01M Tris buffer pH 7.5
Supply related information
Shipped at ambient temperature
Shipped in PP / PE bottle.
Special Info
Available since
Other Fields
Title
CAS ambiguity
Value
# 60132-21-0 belongs to Isobongkrekic acid . http://www.molbase.com/en/cas-60132-21-0.html
Title
oral LD50
Value
oral LD50 of the purified Flavotoxin A in mice 3.16 mg/kg
Title
More identity comments; Hu WJ et al; Biomed Environ Sci 2 (1): 65-71 (1989)
Value
Therefore, Flavotoxin A and bongkrekic acid are the same organic chemical compound; the molecular formula is C28H38O7. The oral LD50 of the purified Flavotoxin A in mice was 3.16 mg/kg (1.53-6.15 mg/kg).
Title
Deleted CAS Registry Numbers
Value
11002-93-0, 12715-13-8, 32839-39-7
Title
oral LD50
Value
ANOTHER SOURCE: MOUSE LDL0=6.85 mg/kg PMID:6391376
Fermentek Product Category
Signal to sort
B
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