Synonyms: Potassium ionophore I
Valinomycin is a cyclododecadepsipeptide ionophore antibiotic produced by Streptomyces fulvissimus and chemically related to the enniatins.
cyclic oligopeptide Ionophore
Valinomycin is a potassium ionophore, research reagent in the field of cell membrane biophysics. It possesses antifungal, antibacterial and antiviral properties.
- As an antiviral agent, Valinomycin is considered for the treatment of Coronavirus diseases.
- As an antibacterial agent, it is considered to be used in bio-diesel manufacturing.
- As a potassium ionophore, valinomycin acts as a nonmetallic agent in potassium selective electrodes.
- Valinomycin acts as an apoptosis inducer
Zhang, Dong; Ma, Zhi; Chen, Hanchi; Lu, Yuele; Chen, Xiaolong (October 2020)
Valinomycin as a potential antiviral agent against coronaviruses: A review
Biomedical Journal Volume 43, Issue 5, October 2020, Pages 414-423
Joko T. Wibowo, Matthias Y. Kellermann, Matthias Köck, Masteria Y. Putra, Tutik Murniasih, Kathrin I. Mohr, Joachim Wink, Dimas F. Praditya Eike Steinmann, Peter J. Schupp
Anti-Infective and Antiviral Activity of Valinomycin and Its Analogues from a Sea Cucumber-Associated Bacterium, Streptomyces sp
Mar Drugs. 2021 Feb; 19(2): 81
Sayed S. Daoud; R. L. Juliano
Reduced Toxicity and Enhanced Antitumor Effects in Mice of the Ionophoric Drug Valinomycin When Incorporated in Liposomes
Cancer Res (1986) 46 (11): 5518–5523.
Zachary J. Sandler, Mason R. Firpo, Oreoluwa S. Omoba, Michelle N. Vu, Vineet D. Menachery, Bryan C. Mounce
Novel Ionophores Active against La Crosse Virus Identified through Rapid Antiviral Screening
ASM Journals. Antimicrobial Agents and Chemotherapy. Vol. 64, No. 6