Oligomycin A, 28-oxo-
Oligomycin B: a macrolide antibiotic that inhibits membrane bound mitochondrial ATPase.
Oligomycin B product from Fermentek is practically free of homologs.
Dichloromethane, DMSO, Ethanol, Acetone
macrolide ATPase inhibitor
Oligomycin has been used to probe tumor cell dependence on glycolytic metabolism, the effect of F1F0-ATPase inhibition and ATP depletion on tumor necrosis factor-α (TNF)-induced apoptosis, and the role of oxidative phosphorylation on the activation of BAX and Bak tumor suppressors.
Used as a tool in cytochemistry