Specifications
Chemical identification
Synonyms: Phomin
RTECS: RO0205000
Cytochalasins are a group of about 20 known mycotoxins, which affect actin stress fibers, causing actin depolymerization. Cytochalasin B is capable of interfering with microfilament formation.
Further Information
DMSO or Ethanol. Other info sourcesRTECS NumberRO0205000LD50 - Lethal dose, 50 percent killIntraperitonealRodent - rat11 mg/kgBehavioral - ataxia Behavioral - coma Lungs, Thorax, or Respiration - cyanosisTOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 17,137,1979LD50 - Lethal dose, 50 percent killIntraperitonealRodent - mouse30 mg/kgDetails of toxic effects not reported other than lethal dose valueFEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 38,438,1979REPROTOXTDLo - Lowest published toxic doseOralRodent - mouse1500 ug/kgfemale 8 day(s) after conceptionReproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal systemTJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 35,87,1987 TOXICOLOGY REVIEWMUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 526,85,2003TOXICOLOGY REVIEWMUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 628,67,2007TOXICOLOGY REVIEWMUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 26,3,2011TOXICOLOGY REVIEWMUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 26,223,2011TOXICOLOGY REVIEWMUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 759,49,2014TOXICOLOGY REVIEWMUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 770,204,2016
Macrolide indol mycotoxin
Cytochalasin
Actin inhibitor
Inhibits cell division by interfering with the formation of contractile microfilaments. Inhibits cell movement and induces nuclear extrusion. Interferes with actin polymerization. Inhibits glucose transport
