Actinomycin D

Molecular Formula:

C62H86N12O16

CAS number:

50-76-0

Fermentek product code:

DAC

Source:

Streptomyces SP

Brand/grade:

For research

Specifications

Appearance:

Red Shiny Crystals

Purity by HPLC:

≥98% at 254 or 441nm

Purity By TLC:

Single spot on TLC plates by multiple methods

Melting point:

245°C to 260°C

Solubility test:

Clear orange solution at 50mg/ml; DMSO; Clear orange solution at 10mg/ml; Methanol:

Chemical identification

Names and identifiers:

Synonyms:

Actinomycin IV ,
Actinomycin C1,
Dactinomycin,
Cosmegen

IUPAC Name:
2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide

Chemical name
Dactinomycin

RTECS#:
AU1575000

EU number:

200-063-6

Description:

Actinomycin D is an antibiotic, a member of Actinomycins group, derived from Streptomyces parvullus. Actinomycin D binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines.

Molecular weight:

1 255.50

InChl Key:

RJURFGZVJUQBHK-IIXSONLDSA-N

Canonical SMILES:

CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C

Isomeric SMILES:

C[C@@H]1[C@@H](C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N(CC(=O)N([C@H](C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)N[C@H]6[C@H](OC(=O)[C@@H](N(C(=O)CN(C(=O)[C@@H]7CCCN7C(=O)[C@H](NC6=O)C(C)C)C)C)C(C)C)C)N)C

Further Information

Solubility ( literature ):

Actinomycin D is soluble in Dichloromethane or Methanol

Compound Classification:

Oligopeptide antibiotic;

RNA polymerase inhibitor

Storage, handling:

Store in a freezer upon arrival, at -10°C to -25°C

Protect from light !

Use the original container to store the product.

Keep the lid tightly closed.

Other vendors may recommend higher temperatures for storage.

Very photo-sensitive.

Expiration time:

Applications:

Inhibitor of DNA-primed RNA polymerase and DNA polymerase. An apoptosis inducer. Antineoplastic drug

Disclaimer:

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Composition

Ingredient type:

Fermentek product

Special Info

Available since:

2003

Other Fields

Title:

Deleted CAS Numbers

Value:

1402-51-3; 1402-58-0; 1421227-25-9;

Title:

Transport information

Value:

PG II

Title:

sig

Value:

114666

Title:

TSE

Value:

Title:

CN code

Value:

29419000

Title:

Proposition65: Cancer

Value:

listed

Title:

Proposition65: Reproductive Toxicity

Value:

Listed

Title:

Proposition65:No Significant Risk Level

Value:

0.00008 µg/day

Actinomycin D

Specifications

Chemical identification

Further Information

Composition

Special Info

Other Fields

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