Verruculogen

Molecular Formula:

C27H33N3O7

CAS number:

12771-72-1

EU number:

634-189-1

Fermentek product code:

VER

Source:

Penicillium simplicissimum

Brand/grade:

For research

Specifications

Appearance:

White powder

Purity by HPLC:

≥97% ; refer to CoA for more data

Purity By TLC:

≥98% ; refer to CoA for more data

Melting point:

227°C -233°C

Chemical identification

Names and identifiers:

IUPAC NAME:(5S,10S,10aR,14aS,15bS)-10,10a-Dihydroxy-7-methoxy-2,2-dimethyl-5-(2-methyl-1-propen-1-yl)-1,10,10a,14,14a,15b-hexahydro-12H-3,4-dioxa-5a,11a,15a-triazacycloocta[1,2,3-lm]indeno[5,6-b]fluorene-11,15(2 H,13H)-dione

Description:

Verruculogen is a tremorgenic mycotoxin, affecting CNS functions, arresting mammary carcinoma cells in vitro, affecting potassium channels. Verruculogen decreases GABA levels in CNS. Tremorgenic doses of verruculogen increase the number and decrease the affinity of DHP receptors in rat cortex. Verruculogen is a potent inhibitor of high conductance Ca activated K (maxi-K) channel.

Molecular weight:

511.57

InChl Key:

LRXYHMMJJCTUMY-KZXQSYCZSA-N

Canonical SMILES:

CC(=CC1N2C3=C(C=CC(=C3)OC)C4=C2C(CC(OO1)(C)C)N5C(=O)C6CCCN6C(=O)C5(C4O)O)C

Isomeric SMILES:

CC(=C[C@H]1N2C3=C(C=CC(=C3)OC)C4=C2[C@H](CC(OO1)(C)C)N5C(=O)[C@@H]6CCCN6C(=O)[C@@]5([C@H]4O)O)C

Further Information

Solubility ( literature ):

Soluble in benzene, ethyl acetate, and acetone; slightly soluble in ethanol; very soluble in CHCI;

Compound Classification:

Tremorgenic neurotoxin affecting central neural system.

Storage, handling:

Store in a freezer upon arrival, at -10°C to -25°C

Use the original container to store the product.

Keep the lid tightly closed.

Avoid exposing to strong direct light.

Protect from moisture! Hygroscopic substance.

Applications:

Verruculogen decreases GABA levels in CNS. Tremorgenic doses of verruculogen increase the number and decrease the affinity of DHP receptors in rat cortex.Verruculogen is a potent inhibitor of high conductance Ca activated K (maxi-K) channel.

Disclaimer:

For Research use only.

Warnings:

Warning or harmful

Expoint_big.jpg

Composition

Ingredient type:

Fermentek product

Special Info

Available since:

2006

Other Fields

Title:

Transport information

Value:

Not hazardous for transport