[D-Asp3] Microcystin LR

Molecular Formula:

C48H72N10O12

CAS number:

120011-66-7

EU number:

Not on ECHA (as at July 2022)

Fermentek product code:

DMCLR

Source:

Microcystis aeruginosa

Brand/grade:

For research

Specifications

Appearance:

White powder

Purity by HPLC:

≥98% ; refer to CoA for more data

Solubility test:

Clear colorless solution at 1mg/ml Methanol

Chemical identification

Names and identifiers:

Synonyms:

Asp3-Microcystin LR
Microcystin A
Microcystin-[D-Asp3]-LR
3-Desmethylmicrocystin LR
Toxin II (Microcystis aeruginosa)
Toxin T 16 (Microcystis aeruginosa)
4-D-β-Aspartic acid-5-L-argininemicrocystin LA

Chemical names:

IUPAC:

(5R,8S,11R,15S,22R)-15-[3-(diaminomethylideneamino)propyl]-18-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dienyl]-1,5,19-trimethyl-2-methylidene-8-(2-methylpropyl)-3,6,9,13,16,20,25-heptaoxo-1,4,7,10,14,17,21-heptazacyclopentacosane-11,22-dicarboxylic acid

IUPAC as peptide

N(1)Arg-Unk-D-gGlu-N(Me)Dha-D-Ala-Leu-D-Asp(1)-OH
Cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-leucyl-D-β-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl]

Chemical name:

Cyanoginosin LA, 4-D-beta-aspartic acid-5-L-arginine-

Description:

Microcystin LR is a cyclic heptapeptide initially produced by species of cyanobacteria Microcystis. Microcystin LR is natural toxin which contaminates water pools. D-Asp-Microcystin LR from Fermentek is used as a reference material in labs busy with water quality. D-Asp-Microcystin LR exhibits cytotoxic, pro-oxidative, and carcinogenic properties.

Molecular weight:

981.15

InChl Key:

VYEBKSHVYPDMQQ-GQYKZJDQSA-N

Canonical SMILES:

CC1C(NC(=O)C(NC(=O)CC(NC(=O)C(NC(=O)C(NC(=O)C(=C)N(C(=O)CCC(NC1=O)C(=O)O)C)C)CC(C)C)C(=O)O)CCCN=C(N)N)C=CC(=CC(C)C(CC2=CC=CC=C2)OC)C

Isomeric SMILES:

C[C@@H]1C(=O)N[[email protected]](C(=O)N[[email protected]](CC(=O)N[[email protected]](C(=O)NC(C(C(=O)N[[email protected]](CCC(=O)N(C(=C)C(=O)N1)C)C(=O)O)C)/C=C/C(=C/[[email protected]](C)[[email protected]](CC2=CC=CC=C2)OC)/C)CCCN=C(N)N)C(=O)O)CC(C)C

Further Information

Storage, handling:

Store in a freezer upon arrival, at -10°C to -25°C

Open carefully.

Use the original container to store the product.

Keep the lid tightly closed.

Avoid exposing to strong direct light.

Other vendors may recommend higher temperatures for storage.

Protect from moisture!

Disclaimer:

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Composition

Ingredient type:

Fermentek product

Supply related information

Supply related comments:

Customs: Other Antibiotics-29419000

Shipped at ambient temperature

Shipped in amber-glass vials

Special Info

Available since:

2021

Other Fields

Title:

Deleted CAS Registry Numbers

Value:

128657-48-7 ; 135258-17-2 ; 374589-84-1

Title:

literature

Value:

IARC Monographs on the Evaluation of Carcinogenic Risks to Humans VOLUME 94