Cyclopamine is a natural steroidal jerveratrum alkaloide. Cyclopamine is named after its ability to cause cyclopia(holoprosencephaly) in unborn sheep.
Insoluble in water. Freely soluble in Chloroform, Dichloromethane.Fairly soluble in benzene, warm (50ºC-60ºC) ethanol (20 mg/mL ), DMSO (4 mg/ml) and DMF (10 mg/mL). May recrystallize from ethanolic solution in cold.
- Veratrum Alkaloid
- Hh inhibitor
Known teratogen. Causes damage to embryos. Women who are or may be pregnant should avoid any contact with Cyclopamine