Cyclopamine

Molecular Formula

C27H41NO2

M.W.

411.62

CAS number

4449-51-8

MSDS

Download

Details

Source

Veratrum californicim (plant extract)

Fermentek product Code

CLP-001

Brand/grade

For research

Specifications

Appearance

White to off white powder

Purity by HPLC

≥98% ; refer to CoA for more data

Purity By TLC

≥98% ; refer to CoA for more data

Solubility test

Clear colorless solution at 5mg/ml DMSO or Methanol

Chemical identification

Names and identifiers

Synonyms: 11-deoxojervine

RTECS: GY0750000

EU number

628-058-8

Description

Cyclopamine is a natural steroidal jerveratrum alkaloide. Cyclopamine is named after its ability to cause cyclopia(holoprosencephaly) in unborn sheep.

InChl Key

QASFUMOKHFSJGL-LAFRSMQTSA-N

Canonical SMILES

CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5CC4=C3C)C)O)C)NC1

Isomeric SMILES

C[C@H]1C[C@@H]2[C@H]([C@H]([C@]3(O2)CC[C@H]4[C@@H]5CC=C6C[C@H](CC[C@@]6([C@H]5CC4=C3C)C)O)C)NC1

Further Information

Solubility ( literature )

Insoluble in water. Freely soluble in Chloroform, Dichloromethane.Fairly soluble in benzene, warm (50ºC-60ºC) ethanol (20 mg/mL ), DMSO (4 mg/ml) and DMF (10 mg/mL). May recrystallize from ethanolic solution in cold.

Compound Classification