Staurosporine (AM-2282) is a natural antibiotic, first isolated in 1977 from Streptomyces staurosporeus (Omura et al, 1977). Staurosporine displays strong inhibitory effect against a variety of kinases. In addition, Staurosporine and its analogues exhibit antifungul, antibacterial and immunosuppressive activities. Staurosporine inhibit protein kinase C (PKC) by completely binding at the PKC ATP-binding site. Due to its strong inhibitory effect... Read More
Filipin III 01.06.2017
Filipin III is the major component of Filipin complex, which includes also: Filipin I, Filipin II and Filipin IV. Filipin complex was first isolated from culture of Streptomyces Filipinensis by Whitfield et al in 1955. Recently Filipin III was identified also in a culture of S. miharaensis (Kim at el, 2012).   Biological Activity and Applications Filipin III is a polyene macrolide antibiotic which exhibits antifungal activity (Whitfield at el,... Read More