DNA replication inhibitors

Details

Source

Streptomyces netropsis

Fermentek product Code

Brand/grade

For research

Specifications

Appearance

White to slight yellow powder

Purity by HPLC

≥98% ; refer to CoA for more data

Purity By TLC

≥98% ; refer to CoA for more data

Melting point

241°C-247°C

Solubility test

Clear colorless to slight yellow solution at 1mg/ml of H2O

Chemical identification

Names and identifiers

Synonyms:

Congocidin
Sinanomycin
Netropsin

IUPAC: N-{5-[(3-amino-3-iminopropyl)carbamoyl]-1-methyl-1H-pyrrol-3-yl}-4-{[N-(diaminomethylidene)glycyl]amino}-1-methyl-1H-pyrrole-2-carboxamide

RTECS DW2974000

EU number

634-294-2

Chemical name

Netropsin dihydrochloride

Description

A basic cytotoxic polypeptide from Streptomyces netropsis. Netropsin binds to A-T sequences of DNA.

InChl Key

QZOOZUGORDEYCC-UHFFFAOYSA-N

Canonical SMILES

CN1C=C(C=C1C(=O)NCCC(=O)N)NC(=O)C2=CC(=CN2C)N=C(CN=C(N)N)N.Cl

Further Information

Compound Classification

Chemical classification:

Pyrrole-amidine antibiotic
Oligopetptide antibiotic

Pharmaceutic classification

Antibacterial
Antiviral

Storage, handling

Store in a freezer upon arrival, at -10°C to -25°C

Open carefully.

Use the original container to store the product.

Keep the lid tightly closed.

Avoid exposing to strong direct light.

Other vendors may recommend higher temperatures for storage.

Protect from moisture!

Disclaimer

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Composition

Ingredient type

Fermentek product

Supply related information

Customs: Other Antibiotics-29419000

Shipped at ambient temperature

Transport safety: Not Dangerous Goods; Not Regulated

Special Info

Available since

2019

Other Fields

Title

Naming and numbering problems

Value

There are ambiguities w/ CAS numbers, naming w/ hydride, chloride etc

Title

Deleted CAS Registry Numbers

Value

554-32-5 - very similar compound. | 1403-42-5, 47686-02-2 - perhaps misformed numbers

Fermentek Product Category

Read more about Netropsin 2HCl

Signal to sort

Altertoxin I

Molecular Formula

C20H16O6

M.W.

352.34

CAS number

56258-32-3

MSDS

Details

Source

Alternaria sp.

Fermentek product Code

ALX-001

Brand/grade

For research

Specifications

Appearance

Off-White to yellowish powder

Purity by HPLC

≥95% ; refer to CoA for more data

Purity By TLC

≥98% ; refer to CoA for more data

Solubility test

Clear slight yellow solution at 10mg/ml Methanol

Chemical identification

Names and identifiers

Synonyms:

(12S,12As,12Br)-4,9,12,12B-Tetrahydroxy-2,11,12,12A-Tetrahydro-1H-Perylene-3,10-Quinone;
Altertoxin I
Altertoxin-I

Chemical names:

IUPAC:

(12S,12aS,12bR)-4,9,12,12b-tetrahydroxy-2,11,12,12a-tetrahydro-1H-perylene-3,10-dione

RTECS# : BC9625200

Description

Altertoxin-1, a natural mycotoxin from Alternaria fungi, an important contaminant in cereals, vegetables.

InChl Key

GJIALGLHOBXNAT-KPOBHBOGSA-N

Canonical SMILES

C1CC2(C3C4C(O4)C(=O)C5=C(C=CC(=C35)C6=C2C(=C(C=C6)O)C1=O)O)O

Isomeric SMILES

C1C[C@]2([C@@H]3[C@H](CC(=O)C4=C(C=CC(=C34)C5=C2C(=C(C=C5)O)C1=O)O)O)O

Further Information

Storage, handling

Store in a freezer upon arrival, at -10°C to -25°C

Open carefully.

Use the original container to store the product.

Keep the lid tightly closed.

Avoid exposing to strong direct light.

Other vendors may recommend higher temperatures for storage.

Applications

Altertoxin I (and other altertoxins) inhibit the HIV replication.

Disclaimer

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Composition

Ingredient type

Fermentek product

Special Info

Available since

2014

Other Fields

Title

tsa

Value

V=veg fermentation

Title

classif

Value

cytotoxic; mutagenic

Fermentek Product Category

Anti Viral

Read more about Altertoxin I

Signal to sort

T2 Toxin

Molecular Formula

C24H34O9

M.W.

466.52

CAS number

21259-20-1

MSDS

Details

Source

Fusarium tricinctum

Fermentek product Code

T2T-001

Brand/grade

For research

Specifications

Appearance

White powder

Purity by HPLC

≥98% ; refer to CoA for more data

Purity By TLC

≥98% ; refer to CoA for more data

Melting point

150°C-154°C

Solubility test

Clear colorless solution at 5mg/ml Dichloromethane

Chemical identification

Names and identifiers

Synonyms

Fusariotoxin T2
T2 TOXIN
MYCOTOXIN T2
8-(3-Methylbutyryloxy)-diacetoxyscirpenol
Trichothec-9-ene-3.alpha.,8.alpha.,15-tetrol, 12,13-epoxy-, 4,15-diacetate 8-isovalerate

RTECS: YD0100000

EU number

244-297-7

Chemical name

T2 TOXIN

Description

T2 Toxin: A trichothecene group mycotoxin, of the most important Fusarium toxins.

InChl Key

BXFOFFBJRFZBQZ-QYWOHJEZSA-N

Canonical SMILES

CC1=CC2C(CC1OC(=O)CC(C)C)(C3(C(C(C(C34CO4)O2)O)OC(=O)C)C)COC(=O)C

Isomeric SMILES

CC1=C[C@@H]2[C@](C[C@@H]1OC(=O)CC(C)C)([C@]3([C@@H]([C@H]([C@H]([C@@]34CO4)O2)O)OC(=O)C)C)COC(=O)C

Further Information

Solubility ( literature )

Dichloromethane, DMSO, Ethanol, Ethyl Acetate. Slightly soluble in petroleum ether; very slightly soluble in water.

Compound Classification

Trichothecene Mycotoxin

Storage, handling

Store in a freezer upon arrival, at -10°C to -25°C

Open carefully.

Use the original container to store the product.

Keep the lid tightly closed.

Other vendors may recommend higher temperatures for storage.

Applications

T-2 toxin has been reported to be used to increase blood-brain barrier permeability in rats.

T-2 Toxin induces DNA damage and cell death on prolonged administration.

Composition

Ingredient type

Fermentek product

Special Info

Available since

2004

Other Fields

Title

Transport information

Value

PG I

Fermentek Product Category

Read more about T2 Toxin

Signal to sort

Okadaic Acid

Molecular Formula

C44H68O13

M.W.

805.00

CAS number

78111-17-8

Details

Source

Marine dinoflagellates

Fermentek product Code

OKA-001

Brand/grade

For research

Specifications

Appearance

White powder

Purity by HPLC

≥90% ; refer to CoA for more data

Purity By TLC

≥98% ; refer to CoA for more data

Solubility test

Clear colorless solution at 5mg/ml EtOH;
Clear colorless solution at 40mg/ml DMSO

Chemical identification

Names and identifiers

RTECS AA8227800

EU number

616-589-8

Chemical name

Acanthifolicin, 9,10-deepithio-9,10-didehydro-

Description

Inhibitor of protein phosphatase

InChl Key

QNDVLZJODHBUFM-WFXQOWMNSA-N

Canonical SMILES

CC1CCC2(CCCCO2)OC1C(C)CC(C3C(=C)C(C4C(O3)CCC5(O4)CCC(O5)C=CC(C)C6CC(=CC7(O6)C(CCC(O7)CC(C)(C(=O)O)O)O)C)O)O

Isomeric SMILES

C[C@@H]1CC[C@]2(CCCCO2)O[C@@H]1[C@@H](C)C[C@@H]([C@@H]3C(=C)[C@H]([C@H]4[C@H](O3)CC[C@]5(O4)CC[C@@H](O5)/C=C/[C@@H](C)[C@@H]6CC(=C[C@@]7(O6)[C@@H](CC[C@H](O7)C[C@](C)(C(=O)O)O)O)C)O)O

Further Information

Solubility ( literature )

Reportedly, Okadaic acid is soluble in acetone, methanol, ethanol, chloroform or ethyl acetate.

Compound Classification

Polyether antibiotic

Storage, handling

Store in a freezer upon arrival, at -10°C to -25°C

Applications

Okadaic Acid is a potent non-TPA type tumor promoter and vasodilator. It induces hyperphosphorylation of the P53 oncoprotein

Composition

Ingredient type

Fermentek product

Special Info

Available since

2012

Other Fields

Title

Additional Transport Information:

Value

De Minimis Quantities exemption, per IATA 2.6.10 - applicable.

Title

Transpoprt information

Value

Pg III

Title

Storage considerations

Value

Some other sources recommend storing under inert gase

Fermentek Product Category

Apoptosis related

Protein kinase related

Research field: Signal Transduction

Others

Read more about Okadaic Acid

Signal to sort

Mithramycin A

Molecular Formula

C52H76O24

M.W.

1 085.00

CAS number

18378-89-7

MSDS

Details

Source

Streptomyces argillaceus

Fermentek product Code

MTA-001

Brand/grade

For research

Specifications

Appearance

Yellow powder

Purity by HPLC

≥98% ; refer to CoA for more data

Purity By TLC

≥98% ; refer to CoA for more data

Melting point

175°C-185°C

Solubility test

Clear yellowish solution at 100mg/ml DMSO

Chemical identification

Names and identifiers

Synonyms:

Mithramycin
Plicamycin
Aureolic acid

RTECS: PZ2800000

EU number

634-048-4

Description

Oligosaccharide antibiotic, a RNA synthesis inhibitor.

InChl Key

CFCUWKMKBJTWLW-BKHRDMLASA-N

Canonical SMILES

CC1C(C(CC(O1)OC2CC(OC(C2O)C)OC3=CC4=CC5=C(C(=O)C(C(C5)C(C(=O)C(C(C)O)O)OC)OC6CC(C(C(O6)C)O)OC7CC(C(C(O7)C)O)OC8CC(C(C(O8)C)O)(C)O)C(=C4C(=C3C)O)O)O)O

Isomeric SMILES

C[C@@H]1[C@H]([C@@H](C[C@@H](O1)O[C@@H]2C[C@@H](O[C@@H]([C@H]2O)C)OC3=CC4=CC5=C(C(=O)[C@H]([C@@H](C5)[C@@H](C(=O)[C@H]([C@@H](C)O)O)OC)O[C@H]6C[C@H]([C@@H]([C@H](O6)C)O)O[C@H]7C[C@H]([C@H]([C@H](O7)C)O)O[C@H]8C[C@]([C@@H]([C@H](O8)C)O)(C)O)C(=C4C(=C3C)O)O)O)O

Further Information

Solubility ( literature )

DMSO, Methanol, Ethanol

Compound Classification

Anthracycline Pentaglycosidic antibiotic.

RNA synthesis inhibitor

Storage, handling

Store in a freezer upon arrival, at -10°C to -25°C

Protect from moisture

Avoid exposing to strong direct light.

Store under argon.

Other vendors may recommend higher temperatures for storage.

Applications

DNA binding fluorescent dye. Until 2000 it was used to reduce high levels of plasma calcium. Used as an antineoplastic agent in the treatment of testicular cancer, Paget's disease of bone, and, rarely, the management of hypercalcemia.

Disclaimer

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Composition

Ingredient type

Fermentek product

Special Info

Available since

2004

Other Fields

Title

Transport information

Value

Not dangerous goods

Title

Deleted CAS numbers

Value

1395-17-1; 1403-98-1; 12708-66-6; 12708-67-7; 23973-19-5; 97666-60-9; 219612-19-8; 744999-90-4; 807260-73-7; 826336-23-6; 899900-19-7; 1195235-16-5

Title

CN code

Value

29419000

Title

toxicity by RTECS

Value

LD50 oral mouse 500 mg/kg

Title

toxicity by RTECS

Value

TDLo oral human 50 ug/kg* 5D

Title

EPA USA status

Value

EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation

Fermentek Product Category

Antibiotics

Angiogenesis related

Anti Viral

Cancer Related Compounds

Immunomodulators

Read more about Mithramycin A

Signal to sort

Deoxynivalenol

Deoxynivalenol (DON)

Molecular Formula

C15H20O6

M.W.

296.30

CAS number

51481-10-8

MSDS

Protein synthesis inhibitors

Details

Source

Semisynthetic

Fermentek product Code

DON-001

Brand/grade

For research

Specifications

Appearance

White crystalline solid.

Purity by HPLC

≥98% ; refer to CoA for more data

Purity By TLC

≥98% ; refer to CoA for more data

Melting point

150°C-155°C

Solubility test

Clear colorless solution at 10mg/ml Methanol or Ethyl acetate

Chemical identification

Names and identifiers

Rd toxin
Vomitoxin
Deoxynivalenol
4-Deoxynivalenol
Dehydronivalenol
4-Desoxynivalenol

RTECS YD0167000

EU number

610-668-0

Description

Deoxynivalenol (DON , Vomitoxin) is a type B trichothecene. It occurs in grains such as wheat, barley, oats, rye, and maize, rice, sorghum. Deoxynivalenol (DON ) is produced by numerous strains of Fusarium and some other fungi. Deoxynivalenol (DON ) poisonings occur both in humans and farm animals. Deoxynivalenol (DON ) is highly toxic, producing a wide range of immunological disturbances and is particularly noted for inducing feed refusal and emesis in pigs, hence the alternative name vomitoxin Deoxynivalenol (DON ) usually co-occurs with other Fusarium toxins, such as Zearalenone, Nivalenol and its derivates, as well as the group of fumonisins.

InChl Key

LINOMUASTDIRTM-QGRHZQQGSA-N

Canonical SMILES

CC1=CC2C(C(C1=O)O)(C3(CC(C(C34CO4)O2)O)C)CO

Isomeric SMILES

CC1=C[C@@H]2[C@]([C@@H](C1=O)O)([C@]3(C[C@H]([C@H]([C@@]34CO4)O2)O)C)CO

Further Information

Solubility ( literature )

Deoxynivalenol (DON ) is soluble in common polar organic solvents as acetonitrile, methanol and ethyl acetate, slightly soluble in water.

Compound Classification

trichothecene type B mycotoxin

Storage, handling

Store in a freezer upon arrival, at -10°C to -25°C

Protect from moisture

Other vendors may recommend higher temperatures for storage.

Applications

The main toxic effect of Deoxynivalenol (DON ) is inhibition of protein synthesis via binding to the ribosome.In agricultural R&D, DON is widely used to select crops strains with increased resistance against Fusarium.

Disclaimer

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Semi-Synthetic

Composition

Ingredient type

Fermentek product

Special Info

Available since

2007

Other Fields

Title

Deleted CAS Numbers

Value

50722-37-7 ; 115825-61-1 ; 1394244-12-2

Fermentek Product Category

Immunosupressors

Immunomodulators

Read more about Deoxynivalenol

Signal to sort

Aphidicolin

Molecular Formula

C20H34O4

M.W.

338.48

CAS number

38966-21-1

MSDS

Details

Source

Nigrospora oryzae

Fermentek product Code

APH-001

Brand/grade

For research

Specifications

Appearance

White to Off-White powder

Purity by HPLC

≥98% ; refer to CoA for more data

Purity By TLC

≥98% ; refer to CoA for more data

Melting point

228°C-233°C

Solubility test

Clear colorless solution at 50mg/ml of DMSO, 10mg/ml of Methanol

Chemical identification

Names and identifiers

RTECS: PB9185000

EU number

609-602-3

Description

Aphidicolin is an antiviral antibiotic produced by Nigrospora oryzae and other fungi. Aphidicolin inhibits the growth of eukaryotic cells and certain animal viruses by selectively inhibiting the cellular replication of DNA polymerase II or the viral-induced DNA polymerases. The drug may be useful for controlling excessive cell proliferation in patients with cancer, psoriasis or other dermatitis, while having no effect on non-multiplying cells.

InChl Key

NOFOAYPPHIUXJR-APNQCZIXSA-N

Canonical SMILES

CC12CCC(C(C1CCC3C24CCC(C(C3)C4)(CO)O)(C)CO)O

Isomeric SMILES

C[C@]12CC[C@H]([C@@]([C@@H]1CC[C@@H]3[C@@]24CC[C@@]([C@H](C3)C4)(CO)O)(C)CO)O

Further Information

Solubility ( literature )

Methanol, DMSO

Compound Classification

tetracyclic mycotoxin

DNA polymerase A inhibitor

Antiviral

Chemical classification:

A tetracyclic diterpene antibiotic.

Biological classification:

Antiviral, antimithotical
Specific inhibitor of DNA polymerase A

Storage, handling

Store in a freezer upon arrival, at -10°C to -25°C

Applications

Aphidicolin inhibits the growth of eukaryotic cells and certain animal viruses by selectively inhibiting the cellular replication of DNA polymerase II or the viral-induced DNA polymerases. The drug may be useful for controlling excessive cell proliferation in patients with cancer, psoriasis or other dermatitis with little or no adverse effect upon non-multiplying cells.Aphidicolin is a tool in cell proliferation and differentiation research. Aphidicolin may possibly be used for controlling excessive cell proliferation in cancer, psoriasis or other dermatitis with little or no adverse effect upon non-multiplying cells.

Disclaimer

Refer to MSDS for further safety and handling instructions.

Composition

Ingredient type

Fermentek product

Special Info

Available since

2005

Other Fields

Title

Additional Comments

Value

Elemental analysis may be performed for some lots

Title

Transport information

Value

Not hazardous for transport

Title

sig

Value

178273

Title

TSE

Value

Fermentek Product Category

Antibiotics

Cytotoxic agents

Apoptosis related

Anti Viral

Anti Tumor agents

Read more about Aphidicolin

Signal to sort

Alternariol monomethyl ether

Molecular Formula

C15H12O5

M.W.

272.25

CAS number

23452-05-3

MSDS

Details

Source

Alternaria alternata

Fermentek product Code

AME-001

Brand/grade

For research

Specifications

Appearance

Off-white to light pink powder

Purity by HPLC

≥98% ; refer to CoA for more data

Purity By TLC

≥98% ; refer to CoA for more data

Melting point

255°C-270°C

Solubility test

Clear colorless solution at 1mg/ml Acetone.
Clear colorless solution at 1mg/ml Methanol (slight heating).

Chemical identification

Names and identifiers

Alternate names

AME
Djalonensone
Alternariol monomethyl ether
Alternariol methyl ether
Alternariol-9-methyl ether

RTECS : HP8755000

EU number

636-657-0

Description

Alternariol monomethyl ether (AME) is a natural mycotoxin originated in Alternaria alternata fungi . It inhibits Cholinesterase, and posesses antifungal and phytotoxic properties.

InChl Key

LCSDQFNUYFTXMT-UHFFFAOYSA-N

Canonical SMILES

CC1=CC(=CC2=C1C3=CC(=CC(=C3C(=O)O2)O)OC)O

Further Information

Solubility ( literature )

Soluble in DMSO, pure ethanol, methanol

Compound Classification

Pyrrolidinone mycotoxin

Storage, handling

Store in a freezer upon arrival, at -10°C to -25°C

Disclaimer

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Composition

Ingredient type

Fermentek product

Supply related information

Non hazardous for shipment.

Special Info

Available since

2010

Other Fields

Title

Transport information

Value

Not hazardous for transport

Title

CAS number validated

Value

26894-49-5; 641-38-3

Title

Deleted CAS Numbers

Value

31273-73-1; 916665-00-4; 11003-13-7

Fermentek Product Category