Mithramycin A
Molecular Formula
C52H76O24
M.W.
1 085.00
CAS number
18378-89-7
MSDS
Source
Streptomyces argillaceus
Fermentek product Code
MTA-001
Brand/grade
For research
Appearance
Yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
175°C-185°C
Solubility test
Clear yellowish solution at 100mg/ml DMSO
Names and identifiers

Synonyms:

  • Mithramycin
  • Plicamycin
  • Aureolic acid

RTECS: PZ2800000

EU number
634-048-4
Description

Oligosaccharide antibiotic, a RNA synthesis inhibitor.

InChl Key
CFCUWKMKBJTWLW-BKHRDMLASA-N
Canonical SMILES
CC1C(C(CC(O1)OC2CC(OC(C2O)C)OC3=CC4=CC5=C(C(=O)C(C(C5)C(C(=O)C(C(C)O)O)OC)OC6CC(C(C(O6)C)O)OC7CC(C(C(O7)C)O)OC8CC(C(C(O8)C)O)(C)O)C(=C4C(=C3C)O)O)O)O
Isomeric SMILES
C[C@@H]1[C@H]([C@@H](C[C@@H](O1)O[C@@H]2C[C@@H](O[C@@H]([C@H]2O)C)OC3=CC4=CC5=C(C(=O)[C@H]([C@@H](C5)[C@@H](C(=O)[C@H]([C@@H](C)O)O)OC)O[C@H]6C[C@H]([C@@H]([C@H](O6)C)O)O[C@H]7C[C@H]([C@H]([C@H](O7)C)O)O[C@H]8C[C@]([C@@H]([C@H](O8)C)O)(C)O)C(=C4C(=C3C)O)O)O)O
Solubility ( literature )

DMSO, Methanol, Ethanol

Compound Classification

Anthracycline Pentaglycosidic antibiotic.

RNA synthesis inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Avoid exposing to strong direct light.
Store under argon.
Other vendors may recommend higher temperatures for storage.
Applications

DNA binding fluorescent dye. Until 2000 it was used to reduce high levels of plasma calcium. Used as an antineoplastic agent in the treatment of testicular cancer, Paget's disease of bone, and, rarely, the management of hypercalcemia.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not dangerous goods
Title
Deleted CAS numbers
Value
1395-17-1; 1403-98-1; 12708-66-6; 12708-67-7; 23973-19-5; 97666-60-9; 219612-19-8; 744999-90-4; 807260-73-7; 826336-23-6; 899900-19-7; 1195235-16-5
Title
CN code
Value
29419000
Title
toxicity by RTECS
Value
LD50 oral mouse 500 mg/kg
Title
toxicity by RTECS
Value
TDLo oral human 50 ug/kg* 5D
Title
EPA USA status
Value
EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation
Signal to sort
M