Cytotoxic agents are dangerous medications, which may be used to treat major and possibly even life-threatening diseases. Cytotoxic agents were initially introduced in medicine for their ability to interrupt nucleic acid and protein synthesis in malignant cells. Subsequently, and on the basis of their immune-suppressing capacities, they were used for the prevention of rejection of allogenic transplanted organs (azathioprine, cyclosporine, and mycophenolate mofetil). The realization that these agents exhibit immunomodulatory capacities led to their use in autoimmune diseases including systemic lupus erythematosus (SLE).

 

Alternariol monomethyl ether

Alternariol monomethyl ether
Molecular Formula
C15H12O5
M.W.
272.25
CAS number
23452-05-3
MSDS
Source
Alternaria alternata
Fermentek product Code
AME-001
Brand/grade
For research
Appearance
Off-white to light pink powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
255°C-270°C
Solubility test
Clear colorless solution at 1mg/ml Acetone.
Clear colorless solution at 1mg/ml Methanol (slight heating).
Names and identifiers

Alternate names

  • AME
  • Djalonensone
  • Alternariol monomethyl ether
  • Alternariol methyl ether
  • Alternariol-9-methyl ether

RTECS : HP8755000

EU number
636-657-0
Description

Alternariol monomethyl ether (AME) is a natural mycotoxin originated in Alternaria alternata fungi . It inhibits  Cholinesterase, and posesses  antifungal and phytotoxic properties.

InChl Key
LCSDQFNUYFTXMT-UHFFFAOYSA-N
Canonical SMILES
CC1=CC(=CC2=C1C3=CC(=CC(=C3C(=O)O2)O)OC)O
Solubility ( literature )

Soluble in DMSO, pure ethanol, methanol

Compound Classification

Pyrrolidinone mycotoxin

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Non hazardous for shipment.
Available since
Title
Transport information
Value
Not hazardous for transport
Title
CAS number validated
Value
26894-49-5; 641-38-3
Title
Deleted CAS Numbers
Value
31273-73-1; 916665-00-4; 11003-13-7
Fermentek Product Category
Food Safety
Mycotoxins
Alternaria toxins
Other mycotoxins
Antibiotics
Cytotoxic agents
Enzyme-inhibitors
Anti Bacterial
Anti Tumor agents
DNA replication inhibitors
Signal to sort
A

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$1.00
Alternariol_monomethyl_ether.gif
Alternariol_monomethyl_ether.gif

Alternariol

Alternariol
Molecular Formula
C14H10O5
M.W.
258.23
CAS number
641-38-3
Source
Alternaria alternata
Fermentek product Code
ALR-001
Brand/grade
For research
Appearance
Off white to slight yellow to slight pink powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
340°C-350°C (decompos.)
Solubility test
Clear colorless solution at 5mg/ml Acetone; Clear colorless solution at 5mg/ml Methanol
Names and identifiers

Synonyms:

  • AOH

Systematic Name :3,7,9-Trihydroxy-1-methyl-6H-dibenzo[b,d]pyran-6-on

RTECS: HP8757000

 

EU number
636-339-1
Description

Alternariol is a mycotoxin that contaminates fruit and cereals. It is named after the fungal genus Alternaria. Alternariol shows anti-fungal and phytotoxic activity. Alternariol inhibits cholinesterase.

InChl Key
CEBXXEKPIIDJHL-UHFFFAOYSA-N
Canonical SMILES
CC1=CC(=CC2=C1C3=CC(=CC(=C3C(=O)O2)O)O)O
Solubility ( literature )

Soluble in DMSO, pure ethanol, methanol

Compound Classification

Pyrrolidinone mycotoxin

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend storing under argon
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Deleted CAS Numbers
Value
11003-13-7
Title
Transport information
Value
Pg III
Fermentek Product Category
Food Safety
Mycotoxins
Food Safety Related
Alternaria toxins
Antibiotics
Cytotoxic agents
Anti Bacterial
Anti Tumor agents
Signal to sort
A

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Price
$1.00
Alternariol.gif
Alternariol.gif

Aflatoxin M1

Aflatoxin M1
Molecular Formula
C17H12O7
M.W.
328.27
CAS number
6795-23-9
MSDS
Source
Aspergillus flavus
Fermentek product Code
AFM-001
Brand/grade
For research
Appearance
White to slight yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 1mg/ml Methanol:ACN (1:1)
Names and identifiers

Chemical names: 4-hydroxyaflatoxin B1

RTECS:  GY1880000

 

EU number
229-865-4
Description

Aflatoxin M1 is a potent hepatotoxic and hepatocarcinogenic mycotoxin, found in milk of cows fed on meal contaminated with Aflatoxin B1

InChl Key
MJBWDEQAUQTVKK-IAGOWNOFSA-N
Canonical SMILES
COC1=C2C3=C(C(=O)CC3)C(=O)OC2=C4C(=C1)OC5C4(C=CO5)O
Isomeric SMILES
COC1=C2C3=C(C(=O)CC3)C(=O)OC2=C4C(=C1)O[C@@H]5[C@]4(C=CO5)O
Solubility ( literature )

Methanol, DMSO

Compound Classification

Furano-furano-Benzopyranmycotoxin

Aflatoxin

Storage, handling
4°C. Protect from light
Retest time
3 Years
Applications

Potent liver carcinogen and DNA-damaging agent.It is also mutagenic, teratogenic, and causes immunosuppression in animals.

Ingredient type
Fermentek product
Available since
Title
Transport information
Value
PG I
Fermentek Product Category
Food Safety
Mycotoxins
Food Safety Related
Aflatoxins
Regulated Mycotoxins
Cytotoxic agents
Signal to sort
A

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Price
$1.00
Aflatoxin_M1
Aflatoxin_M1

Aflatoxin B2

Aflatoxin B2
Molecular Formula
C17H14O6
M.W.
314.29
CAS number
7220-81-7
MSDS
Source
Aspergillus flavus
Fermentek product Code
AFB-002
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
290°C-316°C
Solubility test
Clear colorless solution at 5mg/ml Dichloromethane
Names and identifiers

Dihydroaflatoxin B

HSDB 3454

RTECS: GY1720000

 

 

EU number
230-618-8
Description

8,9-dihidro derivate of aflatoxin B1.

A potent hepatotoxic and hepatocarcinogenic mycotoxin

InChl Key
WWSYXEZEXMQWHT-WNWIJWBNSA-N
Canonical SMILES
COC1=C2C3=C(C(=O)CC3)C(=O)OC2=C4C5CCOC5OC4=C1
Isomeric SMILES
COC1=C2C3=C(C(=O)CC3)C(=O)OC2=C4[C@@H]5CCO[C@@H]5OC4=C1
Solubility ( literature )

DMSO or MeOH

Compound Classification

Furano-furano-Benzopyran-mycotoxin

Aflatoxin

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
PG I
Fermentek Product Category
Food Safety
Mycotoxins
Food Safety Related
Aflatoxins
Regulated Mycotoxins
Cytotoxic agents
Signal to sort
A

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Price
$1.00
Aflatoxin_B2
Aflatoxin_B2

Aflatoxin B1

Aflatoxin B1
Molecular Formula
C17H12O6
M.W.
312.27
CAS number
1162-65-8
MSDS
Source
Aspergillus flavus
Fermentek product Code
AFB-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
260°C-269°C
Solubility test
Clear colorless solution at 10 mg/ml of Dichloromethane
Names and identifiers

2,3,6aα,9aα-tetrahydro-4-methoxycyclopenta[c]furo[2',3':4,5]furo[2,3-h]chromene-1,11-dione

HSDB 3453

EU number
214-603-3
Description

Aflatoxin B1 is a potent hepatotoxic and hepatocarcinogenic mycotoxin. It is also mutagenic, teratogenic, and causes immunosuppression in animals.

InChl Key
OQIQSTLJSLGHID-WNWIJWBNSA-N
Canonical SMILES
COC1=C2C3=C(C(=O)CC3)C(=O)OC2=C4C5C=COC5OC4=C1
Isomeric SMILES
COC1=C2C3=C(C(=O)CC3)C(=O)OC2=C4[C@@H]5C=CO[C@@H]5OC4=C1
Solubility ( literature )

May be dissolved in DCM, DMSO or Methanol

Compound Classification

Furano-furano-Benzopyran mycotoxin Aflatoxin

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Open carefully – Lyophilized solid under vacuum
Retest time
3 Years
Ingredient type
Fermentek product
Shipped in amber-glass vials
Transport safety: class 6.1 PG I
Available since
Title
Transport information
Value
PG I
Title
HS FER recommendation
Value
Laboratory reagents or reference material-38220000
Title
HS--EU
Value
Heterocyclic compounds wi/ oxygen hetero-atom(s) only; lactones; other
Fermentek Product Category
Food Safety
Mycotoxins
Food Safety Related
Aflatoxins
Regulated Mycotoxins
Cytotoxic agents
Signal to sort
A

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Price
$1.00
Aflatoxin_B1
Aflatoxin_B1

Actinomycin D Extra Pure

Actinomycin D Extra Pure
Molecular Formula
C62H86N12O16
M.W.
1 255.42
CAS number
50-76-0
MSDS
Source
Streptomyces parvulus
Fermentek product Code
ACT-002
Brand/grade
For research
Appearance
Red Shiny to Orange-Red Crystals
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
238°C-255°C
Solubility test
Clear orange solution at 50mg/ml DMSO;
Clear orange solution at 10mg/ml Methanol
Names and identifiers

Synonyms:

  • Actinomycin IV ,
  • Actinomycin C1,
  • Dactinomycin,
  • Cosmegen

IUPAC Name:
2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide

Chemical name
Dactinomycin

RTECS#: 
AU1575000

EU number
200-063-6
Description

Actinomycin D is an antibiotic, a member of Actinomycins group, derived from Streptomyces parvullus. Actinomycin D binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines.

InChl Key
RJURFGZVJUQBHK-IIXSONLDSA-N
Canonical SMILES
CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C
Isomeric SMILES
C[C@@H]1[C@@H](C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N(CC(=O)N([C@H](C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)N[C@H]6[C@H](OC(=O)[C@@H](N(C(=O)CN(C(=O)[C@@H]7CCCN7C(=O)[C@H](NC6=O)C(C)C)C)C)C(C)C)C)N)C
Solubility ( literature )

Actinomycin D is soluble in Dichloromethane or Methanol

Compound Classification

Oligopeptide antibiotic;

RNA polymerase inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Use the original container to store the product.
Keep the lid tightly closed.
Other vendors may recommend higher temperatures for storage.
Very photo-sensitive.
Retest time
3 Years
Applications

Inhibitor of DNA-primed RNA polymerase and DNA polymerase. An apoptosis inducer. Antineoplastic drug

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Depreciated CAS Numbers
Value
1402-51-3; 1402-58-0; 1421227-25-9;
Title
Transport information
Value
PG II
Title
sig
Value
114666
Title
TSE
Value
F
Title
CN code
Value
29419000
Title
Proposition65: Cancer
Value
listed
Title
Proposition65: Reproductive Toxicity
Value
Listed
Title
Proposition65:No Significant Risk Level
Value
0.00008 µg/day
Fermentek Product Category
Antibiotics
Cytotoxic agents
Research field: Cancer
Signal to sort
A

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Price
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Actinomycin_D
Actinomycin_D

A23187 free acid

A23187 free acid
Molecular Formula
C29H37N3O6
M.W.
523.62
CAS number
52665-69-7
MSDS
Source
Streptomyces chartreusis
Fermentek product Code
AFA-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
186°C-192°C
Solubility test
Clear colorless solution at 5mg/ml of Ethanol;
Clear colorless solution at 50mM DMSO
Names and identifiers

Synonyms

  • Calcimycin,
  • Calcium Ionophore,
  • A23187

RTECS#   NO0600000

 

EU number
258-084-1
Chemical name
A23187
Description

A23187 ( Calcimycin ) is Mobile ion-carrier that forms stable complexes with divalent cations.

InChl Key
HIYAVKIYRIFSCZ-CVXKHCKVSA-N
Canonical SMILES
CC1CCC2(C(CC(C(O2)C(C)C(=O)C3=CC=CN3)C)C)OC1CC4=NC5=C(O4)C=CC(=C5C(=O)O)NC
Isomeric SMILES
C[C@H]1CCC2([C@@H](C[C@H]([C@H](O2)C(C)C(=O)C3=CC=CN3)C)C)O[C@H]1CC4=NC5=C(O4)C=CC(=C5C(=O)O)NC
Solubility ( literature )

DMSO, Methanol, Dichloromethane . Slightly soluble in water

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend +2 to +8°C storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Shipped at ambient temperature
Transport safety: Not Dangerous Goods; Not Regulated
Amber-glass vial.
Available since
Title
Comment:
Value
Additional tests, such as elemental analysis, may be included in CoA
Title
Deleted CAS numbers
Value
37259-87-3; 37263-57-3; 51257-80-8; 51310-65-7; 53095-21-9
Title
Transport information
Value
Not hazardous for transport
Title
TSE category
Value
F
Title
sig
Value
100105
Fermentek Product Category
Antibiotics
Cytotoxic agents
Ionophores
Signal to sort
A

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Price
$1.00
A23187__Free_Acid
A23187__Free_Acid

15-Acetoxyscirpenol

15-Acetoxyscirpenol
Molecular Formula
C17H24O6
M.W.
324.37
CAS number
2623-22-5
MSDS
Source
Semisynthetic
Fermentek product Code
15A-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
160-167°C
Solubility test
Clear colorless solution at 10 mg/ml Methanol;
Clear colorless solution at 10 mg/ml DMSO
Names and identifiers

Synonyms

MAS

15-Acetoxyscirpenol

15-Monoacetoxyscirpenol

15- Deacetylanguidin

4- Deacetylanguidin

IUPAC names:  15-Acetoxyscirpenol

Chemical names: 15-Mono-O-acetylscirpenol;    Deacetylanguidin;    15-Acetoxyscirpenol;

Systematic Name:  Trichothec-9-ene-3-alpha,4-beta,15-triol, 12,13-epoxy-, 15- acetate

RTECS: YD0111000

EU number
636-756-9
Chemical name
15-Acetoxyscirpenol;
Description

MAS (15-Acetoxyscirpenol) is a Trichothecene class mycotoxin. It is closely related to DAS (Diacetoxyscirpenol)

InChl Key
IRXDUBNENLKYTC-DIRMQTSCSA-N
Canonical SMILES
CC1=CC2C(CC1)(C3(C(C(C(C34CO4)O2)O)O)C)COC(=O)C
Isomeric SMILES
CC1=C[C@@H]2[C@](CC1)(C3([C@@H]([C@H]([C@H](C34CO4)O2)O)O)C)COC(=O)C
Solubility ( literature )

Soluble in moderately polar solvents, such as chloroform, diethyl ether, ethyl acetate, and acetone

Compound Classification

Trichothecene

Mycotoxin

Apoptosis inducer

UNSPSC:

123521 Chemicals, including biochemicals.

121615 Chemicals, Additives, Indicators and reagents    

85151701 Healthcare Services;  Food and nutrition services; Food policy planning and aid; Food standards

85131703  Biomedical research services

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

MAS, as many other anguidine derivates exhibits a strong antimitotic effect,

Disclaimer
Semi-Synthetic
Degree
Grain
Ingredient type
Fermentek product
Title
Transport information
Value
Pg III
Title
Deleted CAS Numbers
Value
174421-33-1; 852222-55-0
Title
CN code
Value
n.a.
Title
CN code
Value
n.a.
Title
C-L inventory
Value
Y
Fermentek Product Category
Food Safety
Food Safety - Sub
Mycotoxins
Food Safety Related
Trichocothecenes
Antibiotics
Cytotoxic agents
Research field: Cancer
Apoptosis related
Signal to sort
A

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Price
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15-Acetoxyscirpenol
15-Acetoxyscirpenol animation
15- Acetoxyscirpenol bottle
15-Acetoxyscirpenol
15-Acetoxyscirpenol animation
15- Acetoxyscirpenol bottle
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