Synonyms: Veratrin (Amorphous)
Chemical names: 4,9-epoxycevane-3β,4α,12,14,16β,17,20-heptol 3-veratrate
IUPAC: (3β,4α,16β)-4,12,14,16,17,20-Hexahydroxy-4,9-epoxycevan-3-yl 3,4-dimethoxybenzoate
Veratridine, plant-derived alkaloid is a potent modulator of voltage dependent Na+channels and hence, of transmitter release. Veratridine reduces the single channel conductance and increases the persistent opening propability.
Pereira,S.P.F. et al.
Associação Brasileira de Divulgação Científica 1997
Veratridine increases the survival of retinal ganglion cells in vitro.
Neuronal cell death is an important phenomenon involving many biochemical pathways. This degenerative event has been studied to understand how the cells activate the mechanisms that lead to self-destruction. Target cells and afferent cells play a relevant role in the regulation of natural cell death...