Leupeptin hemisulfate
Molecular Formula
C20H38N6O4 1/2 (H2SO4)
M.W.
475.60
CAS number
103476-89-7
Source
Synthetic
Fermentek product Code
LEU-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥96% ; refer to CoA for more data
Solubility test
Clear colorless to faint yellow solution at 50mg/ml of Water
Names and identifiers

Synonyms:

 

  • N-acetyl-L-leucyl-L-leucyl-L-argininal hemisulfate
  • L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-formylbutyl]-  hemisulfate
  • L-Leucinamide, N-acetyl-L-leucyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-, (S)-  hemisulfate
  • N-Acetyl-L-leucyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-formylbutyl]-L-niacinamide     hemisulfate
  • Acetyl-L-leucyl-L-leucyl-L-argininal
  • Leupeptin hemisulfate
  • 55123-66-5: parent compound CAS number (Leupeptin)

Chemical names:

IUPAC:

(2S)-2-acetamido-N-[(2S)-1-[[(2S)-5-(diamino methylidene amino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-4-methylpentanamide

RTECS#  

EU number
600-443-5
Chemical name
(2S)-2-acetamido-N-[(2S)-1-[[(2S)-5-(diamino methylidene amino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-4-methylpentanamide
Description

Leupeptin is a membrane-permeable reversible protease inhibitor of serine and cysteine proteases. Leupeptin inhibits plasmin, trypsin, papain, kallikrein, cathepsin B, and calpain.
Leupeptin is also a lysosomal inhibitor.

Chemically, Leupeptin is a tripeptide.

 

InChl Key
CIPMKIHUGVGQTG-VFFZMTJFSA-N
Canonical SMILES
CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CCCN=C(N)N)C=O)NC(=O)C.CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CCCN=C(N)N)C=O)NC(=O)C.OS(=O)(=O)O
Isomeric SMILES
CC(C)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C=O)NC(=O)C.CC(C)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C=O)NC(=O)C.OS(=O)(=O)O
Solubility ( literature )

Reportedly, Salts of leupeptin are reported to be soluble in water, ethanol, acetic acid, and DMF.

Compound Classification

Tripeptide

cysteine endopeptidase inhibitor which interferes with the action of any calpain.

A cysteine protease inhibitor that inhibits cathepsin B

A protease inhibitor that restricts the action of a serine protease.

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Fermentek Product Category