Alamethicin
Molecular Formula
C92H150N22O25
M.W.
1 964.30
CAS number
27061-78-5
MSDS
Source
Trichoderma viride
Fermentek product Code
ALA-001
Brand/grade
For research
Appearance
Off White to Beige powder
Purity by HPLC
4 peaks, complies to standard
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
252°C-272°C
Solubility test
Clear colorless solution at 10mg/ml DMSO or Methanol
Names and identifiers

 

Synonyms: Antibiotic U 22324

RTECS: AY1900000

EU number
608-040-6
Description

Alamethicin is a channel-forming ionophore. Chemically, it is a peptide of 20 amino acids. The product consists of a mixture of several isoforms, which may be slightly different in the amino-acids sequences, but possess the same activity.

 

InChl Key
LGHSQOCGTJHDIL-UTXLBGCNSA-N
Canonical SMILES
CC(C)CC(C(=O)NC(C)(C)C(=O)N1CCCC1C(=O)NC(C(C)C)C(=O)NC(C)(C)C(=O)NC(C)(C)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)N)C(=O)NC(CC2=CC=CC=C2)CO)NC(=O)CNC(=O)C(C)(C)NC(=O)C(C(C)C)NC(=O)C(C)(C)NC(=O)C(CCC(=O)N)NC(=O)C(C)NC(=O)C(C)(C)NC(=O)C(C)NC(=O)C(C)(C)NC(=O)C3CCCN3C(=O)C(C)(C)NC(=O)C
Isomeric SMILES
C[C@@H](C(=O)N[C@@H](CCC(=O)N)C(=O)NC(C)(C)C(=O)N[C@@H](C(C)C)C(=O)NC(C)(C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)NC(C)(C)C(=O)NC(C)(C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC2=CC=CC=C2)CO)NC(=O)C(C)(C)NC(=O)[C@H](C)NC(=O)C(C)(C)NC(=O)[C@@H]3CCCN3C(=O)C(C)(C)NC(=O)C
Solubility ( literature )

DMSO, Methanol, Ethanol

Compound Classification
  1. Peptide antibiotic
  2. Channel forming Ionophore
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Retest time
3 Years
Applications

Can mimic nerve action potential across artificial membranes

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg III
Title
Deleted CAS numbers
Value
11051-59-5; 55739-76-9
Signal to sort
A