Celastrol (Tripterin)

Molecular Formula

C29H38O4

M.W.

450.61

CAS number

34157-83-0

MSDS

Download

Details

Source

Tripterygium wilfordii

Fermentek product Code

CEL-001

Brand/grade

For research

Specifications

Appearance

Red powder

Purity by HPLC

≥98% ; refer to CoA for more data

Purity By TLC

≥98% ; refer to CoA for more data

Melting point

190°C-220°C

Solubility test

Clear red solution at 10mg/ml DMSO,
Clear red solution at 10mg/ml Ethanol

Chemical identification

Names and identifiers

Synonyms:

Tripterin
Celastrol

Chemical names:

RTECS: YJ7900000

EU number

636-472-5

Description

Celastrol is a chemical compound isolated from the root extracts of Tripterygium wilfordii and Celastrus regelii. Celastrol is a pentacyclic triterpenoid and belongs to the family of quinone methides. In mice, celastrol increases expression of IL1R1, which is the receptor for the cytokine interleukin-1. Celastrol is an antioxidant, anti-inflammatory and immunosuppressive agent.

InChl Key

KQJSQWZMSAGSHN-JJWQIEBTSA-N

Canonical SMILES

CC1=C(C(=O)C=C2C1=CC=C3C2(CCC4(C3(CCC5(C4CC(CC5)(C)C(=O)O)C)C)C)C)O

Isomeric SMILES

CC1=C(C(=O)C=C2C1=CC=C3C2(CCC4(C3(CCC5(C4CC(CC5)(C)C(=O)O)C)C)C)C)O

Further Information

Storage, handling

Store in a freezer upon arrival, at -10°C to -25°C

Open carefully.

Use the original container to store the product.

Keep the lid tightly closed.