Fermentek | Blasticidin S · HCl ( 3513-03-9 )

Blasticidin S · HCl

Molecular Formula:

C17H26N8O5·HCl

CAS number:

3513-03-9

EU number:

609-067-6

Fermentek product code:

Source:

Streptomyces griseochromogenes

Brand/grade:

For research

Specifications

Appearance:

White to Off-White powder

Purity by HPLC:

≥98% ; refer to CoA for more data

Purity By TLC:

≥98% ; refer to CoA for more data

Solubility test:

Clear colorless solution at 10mg/ml Water

Chemical identification

Names and identifiers:

Synonyms:

Bla-S
Blasticidin S, monohydrochloride (8CI)

IUPAC Name:

(2S,3S, 6R)-3-[[(3R)-3-amino-5-[carbamimidoyl(methyl)amino]pentanoyl]amino]-6-(4-amino-2-oxopyrimidin-1-yl)-3,6-dihydro-2H-pyran-2-carboxylicacid; hydrochloride

RTECS: EC4900000

Description:

Blasticidin S Hydrochloride belongs to a group of cytosine amino nucleoside antibiotics.The compound Blasticidin S has a wide spectrum of antimicrobial activity and acts on prokaryotic and eukaryotic organisms by inhibiting protein synthesis.

Molecular weight:

458.90

InChl Key:

YQXYQOXRCNEATG-ZAYJLJTISA-N

Canonical SMILES:

N(CCC(CC(=O)NC1C=CC(OC1C(=O)O)N2C=CC(=NC2=O)N)N)C(=N)N.Cl

Isomeric SMILES:

CN(CC[[email protected]](CC(=O)N[[email protected]]1C=C[[email protected]@H](O[[email protected]@H]1C(=O)O)N2C=CC(=NC2=O)N)N)C(=N)N.Cl

Further Information

Solubility ( literature ):

Soluble in water, Acetic acid. Slightly soluble in acidified methanol.

Compound Classification:

Cytosine amino nucleoside type antibiotic

Storage, handling:

Store in a freezer upon arrival, at -10°C to -25°C

Applications:

Blasticidin-S is a commonly used tool in genetic engineering. Blasticidin-S inhibits protein synthesis in both prokaryotic and eukaryotic cells. It is common method to include a gene for Blasticidin S resistance into the plasmid being inserted into the target cells, and then to apply Blasticidin S to the culture to select these cells that have acquired that immunity. The Blasticidin S gene resistance gene (BSR), found in Bacillus cereus K55-S1, has been used in multiple studies for its use as a selective compound. Another antibiotic that belongs to the family of nucleosides is Puromycin.

Disclaimer:

Refer to MSDS for further safety and handling instructions.

Composition

Ingredient type:

Fermentek product

Special Info

Available since:

2015

Other Fields

Title:

Transport information

Value:

Pg II

Title:

REACH status

Value:

On REACH List of Pre-Registered Substances, March 2009 Registration Date: 31-MAY-2018

Title:

Deleted CAS numbers

Value:

885319-52-8