- Antibiotic SL-2052
Wortmannin is a steroid metabolite of the fungus Talaromyces wortmannii. It is a specific covalent inhibitor of phosphoinositide 3-kinases. Wortmannin has been used as precursor of an experimental anti-cancer drug PX-866
DMSO, Methanol.Wortmannin is unstable in aqueous and ethanolic solutions.
- chemical class: Androstadiene.
- phospholipase D inhibitor.
- phosphatidylinositol 3-kinase inhibitor.
Wortmannin is an inhibitor of phosphatidyl-inositol 3-kinase Wortmannin inhibits the growth of mammary tumors despite the existence of a novel wortmannin-insensitive phosphatidylinositol-3-kinase. Wortmannin inhibits repair of DNA double-strand breaks in irradiated normal human cells. Wortmannin was shown to have enhancing influence on memory and impair learning abilities. .