K252c
Molecular Formula
C20H13N3O
M.W.
311.40
CAS number
85753-43-1
Details
Source
Nocardiopsis sp
Fermentek product Code
K2C-001
Brand/grade
For research
Specifications
Appearance
Off-white to yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless to light yellow solution at 7.8mg/ml DMSO (25mM)
Chemical identification
Names and identifiers
Synonyms:
- Staurosporine aglycone;
- Staurosporinone.
- K252C
Description
K252c: Cell permeable protein kinase inhibitor of the Staurosporine family (indolo[2,3-a]carbazole alkaloids)
InChl Key
MEXUTNIFSHFQRG-UHFFFAOYSA-N
Canonical SMILES
C1C2=C3C4=CC=CC=C4NC3=C5C(=C2C(=O)N1)C6=CC=CC=C6N5
Further Information
Solubility ( literature )
Readily soluble in chloroform, acetonitrile, acetone, dioxane, tetrahydrofuran, pyridine;Soluble in ethanol, methanol, 1-propanol, ethyl acetate and n-butanol;Insoluble in water, 2-propanol. Comment: This information has been collected from available scientific sources. It is not a part of product specification
Compound Classification
indolocarbazole alkaloidPKC inhibitor
Storage, handling
-20oC. Protect from light. Hygroscopic. Protect from moisture
Applications
K252c inhibits protein kinase C. Its reported IC50 value of 214 nM on rat brain enzyme K252c is cytotoxic for A549 and P388 cancer celllines showing IC50 = 2-3 μM
Composition
Ingredient type
Fermentek product
Special Info
Available since
Other Fields
Title
Transport information
Value
NDG
Fermentek Product Category
Signal to sort
K