K252a
Molecular Formula
C27H21N3O5
M.W.
467.47
CAS number
99533-80-9
Source
Nocardiopsis sp
Fermentek product Code
K2A-001
Brand/grade
For research
Appearance
White to pale yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
255°C-270°C
Solubility test
Clear colorless to slight yellow solution at 50mg/ml of DMSO
Names and identifiers

RTECS NZ0550000

EU number
640-127-4
Description

K252a: Cell permeable protein kinase inhibitor

InChl Key
KOZFSFOOLUUIGY-IYYJOCMQSA-N
Canonical SMILES
CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)OC)O
Isomeric SMILES
C[C@]12[C@@](C[C@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)OC)O
Solubility ( literature )

Readily soluble in chloroform, acetonitrile, acetone, dioxane, tetrahydrofuran, pyridine;soluble in ethanol, methanol, 1-propanol, ethyl acetate and n-butanol; insoluble in water, 2-propanol

Compound Classification
  • indolocarbazole alkaloid
  • PK inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Protect from light !
Use the original container to store the product.
Keep the lid tightly closed.
Expiration time
3Y
Applications

K252a is a highly potent cell permeable inhibitor of CaM kinase and phosphorylase kinase . At high concentrations it also inhibitors of serine/threonine protein kinases. K252a inhibits tyrosine phosphorylation of Trk A induced by NGF K252a is reported to promote myogenic differentiation in C2 mouse myoblasts

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Title
Deleted CAS Numbers
Value
97161-97-2; 105450-17-7; 108645-76-7; 151004-74-9
Title
Transport information
Value
Not hazardous for transport
Signal to sort
K