Brefeldin A
Molecular Formula
C16H24O4
M.W.
280.36
CAS number
20350-15-6
Source
Eupenicillium brefeldianum
Fermentek product Code
BRF-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
198°C-215°C
Solubility test
Clear colorless solution at 10 mg/ml Methanol
Names and identifiers

Synonyms:

  •         Nectrolide;
  •         Synergisidin;
  •         Cyanaein;
  •         Ascotoxin
  •         Cyanein
  •         Decumbin
  •         Brefeldin A

EC# :     606-528-3

 Systematic name:

(1R,2E,6S,10E,11aS,13S,14aR)-1,13-Dihydroxy-6-methyl-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-4-one

RTECS: GY8410000

EU number
606-528-3
Description

Brefeldin A is a macrocyclic lactone from fungal source, exhibiting a wide range of antibiotic activity.

InChl Key
KQNZDYYTLMIZCT-HHMYAMTESA-N
Canonical SMILES
CC1CCCC=CC2CC(CC2C(C=CC(=O)O1)O)O
Isomeric SMILES
C[C@H]1CCC/C=C/[C@@H]2C[C@@H](C[C@H]2[C@@H](/C=C\C(=O)O1)O)O
Solubility ( literature )

Methanol, Ethanol, Dichloromethane, DMSO, acetone or ethyl acetate

Compound Classification
  • Macrocyclic lactone antibiotic.
  • Antifungal
  • Antiviral
  • Protein Synthesis Inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Applications

Inhibitor of protein translocation from endoplasmic reticulum (ER) to the Golgi apparatus.
Inhibitor of intracellular protein transport and protein secretionA macrolide isolated from Penicillium brefeldianum. It affects the vesticular transport of the Golgi apparatus and induces DNA fragmentation which leads to apoptosis.

 

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Warnings

NotAnimal

No animal ingredients

NotGMO

Product natural

Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg III
Title
sig
Value
203729
Title
TSE
Value
F
Signal to sort
B