Deoxynivalenol (DON)
Molecular Formula
C15H20O6
M.W.
296.30
CAS number
51481-10-8
MSDS
Source
Semisynthetic
Fermentek product Code
DON-001
Brand/grade
For research
Appearance
White crystalline solid.
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
150°C-155°C
Solubility test
Clear colorless solution at 10mg/ml Methanol or Ethyl acetate

Names and identifiers
  • Rd toxin
  • Vomitoxin
  • Deoxynivalenol
  • 4-Deoxynivalenol
  • Dehydronivalenol
  • 4-Desoxynivalenol

RTECS YD0167000

EU number
610-668-0
Description

Deoxynivalenol (DON , Vomitoxin) is a type B trichothecene. It occurs in grains such as wheat, barley, oats, rye, and maize, rice, sorghum. Deoxynivalenol (DON ) is produced by numerous strains of Fusarium and some other fungi. Deoxynivalenol (DON ) poisonings occur both in humans and farm animals. Deoxynivalenol (DON ) is highly toxic, producing a wide range of immunological disturbances and is particularly noted for inducing feed refusal and emesis in pigs, hence the alternative name vomitoxin Deoxynivalenol (DON ) usually co-occurs with other Fusarium toxins, such as Zearalenone, Nivalenol and its derivates, as well as the group of fumonisins.

InChl Key
LINOMUASTDIRTM-QGRHZQQGSA-N
Canonical SMILES
CC1=CC2C(C(C1=O)O)(C3(CC(C(C34CO4)O2)O)C)CO
Isomeric SMILES
CC1=C[C@@H]2[C@]([C@@H](C1=O)O)([C@]3(C[C@H]([C@H]([C@@]34CO4)O2)O)C)CO
Solubility ( literature )

Deoxynivalenol (DON ) is soluble in common polar organic solvents as acetonitrile, methanol and ethyl acetate, slightly soluble in water.

Compound Classification

trichothecene type B mycotoxin

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Other vendors may recommend higher temperatures for storage.
Applications

The main toxic effect of Deoxynivalenol (DON ) is inhibition of protein synthesis via binding to the ribosome.In agricultural R&D, DON is widely used to select crops strains with increased resistance against Fusarium.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Available since
Title
Deleted CAS Numbers
Value
50722-37-7 ; 115825-61-1 ; 1394244-12-2
Signal to sort
D